ID S2538_XENTR Reviewed; 302 AA.
AC Q6DJ08;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 106.
DE RecName: Full=Mitochondrial glycine transporter {ECO:0000255|HAMAP-Rule:MF_03064};
DE AltName: Full=Solute carrier family 25 member 38 {ECO:0000255|HAMAP-Rule:MF_03064};
GN Name=slc25a38 {ECO:0000255|HAMAP-Rule:MF_03064};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mitochondrial glycine transporter that imports glycine into
CC the mitochondrial matrix. Plays an important role in providing glycine
CC for the first enzymatic step in heme biosynthesis, the condensation of
CC glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the
CC mitochondrial matrix. Required during erythropoiesis.
CC {ECO:0000255|HAMAP-Rule:MF_03064}.
CC -!- FUNCTION: May play a role as pro-apoptotic protein that induces
CC caspase-dependent apoptosis. {ECO:0000250|UniProtKB:Q91XD8}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glycine(in) = glycine(out); Xref=Rhea:RHEA:70715,
CC ChEBI:CHEBI:57305; Evidence={ECO:0000250|UniProtKB:Q96DW6};
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_03064}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_03064}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC SLC25A38 subfamily. {ECO:0000255|HAMAP-Rule:MF_03064}.
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DR EMBL; BC075377; AAH75377.1; -; mRNA.
DR RefSeq; NP_001004921.1; NM_001004921.1.
DR AlphaFoldDB; Q6DJ08; -.
DR SMR; Q6DJ08; -.
DR STRING; 8364.ENSXETP00000031412; -.
DR PaxDb; 8364-ENSXETP00000000481; -.
DR DNASU; 448302; -.
DR Ensembl; ENSXETT00000000481; ENSXETP00000000481; ENSXETG00000000232.
DR GeneID; 448302; -.
DR KEGG; xtr:448302; -.
DR AGR; Xenbase:XB-GENE-5814283; -.
DR CTD; 54977; -.
DR Xenbase; XB-GENE-5814283; slc25a38.
DR eggNOG; KOG0766; Eukaryota.
DR HOGENOM; CLU_015166_0_3_1; -.
DR InParanoid; Q6DJ08; -.
DR OMA; KYRYESV; -.
DR OrthoDB; 5174168at2759; -.
DR PhylomeDB; Q6DJ08; -.
DR TreeFam; TF332793; -.
DR Proteomes; UP000008143; Chromosome 4.
DR Bgee; ENSXETG00000000232; Expressed in egg cell and 12 other cell types or tissues.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015187; F:glycine transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.
DR GO; GO:1904983; P:glycine import into mitochondrion; IEA:UniProtKB-UniRule.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 2.
DR HAMAP; MF_03064; SLC25A38; 1.
DR InterPro; IPR030847; Hem25/SLC25A38.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR PANTHER; PTHR46181; MITOCHONDRIAL GLYCINE TRANSPORTER; 1.
DR PANTHER; PTHR46181:SF3; MITOCHONDRIAL GLYCINE TRANSPORTER; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..302
FT /note="Mitochondrial glycine transporter"
FT /id="PRO_0000291807"
FT TRANSMEM 28..53
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT TRANSMEM 87..113
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT TRANSMEM 125..150
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT TRANSMEM 178..201
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT TRANSMEM 217..243
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT TRANSMEM 272..290
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT REPEAT 22..112
FT /note="Solcar 1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT REPEAT 119..203
FT /note="Solcar 2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT REPEAT 213..297
FT /note="Solcar 3"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
SQ SEQUENCE 302 AA; 33335 MW; 6F141EF4F6AD01AD CRC64;
MSDALVMAGE PLMSGNCFSQ MHPVFKAFVC GSLSGTCSTL LFQPLDLVKT RLQAHQLSAS
AAGSRPRMLN LFIKVIRNEN ILGLWRGVSP SFLRCIPGVG LYFSTLYTLK HHFFSERDPK
PLESVMLGAG SRTVAAVCML PFTVVKTRYE SGKYGYKSVY GALKNIYKTE GPRGLFSGLT
ATLMRDAPFS GIYLMFYTRA KKLVPQDQID PLFSPVLNFG CGIVAGILAS VATQPADVIK
THIQLSHEKC HWTGQVALNI YQNHGLTGFF RGGLPRALRR TLMAAMAWTV YEQMMEKMGL
KS
//
