ID   S2J713_MUCC1            Unreviewed;       264 AA.
AC   S2J713;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=Sepiapterin reductase {ECO:0000256|ARBA:ARBA00019170};
DE            EC=1.1.1.153 {ECO:0000256|ARBA:ARBA00013075};
GN   ORFNames=HMPREF1544_07312 {ECO:0000313|EMBL:EPB85896.1};
OS   Mucor circinelloides f. circinelloides (strain 1006PhL) (Mucormycosis
OS   agent) (Calyptromyces circinelloides).
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC   Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX   NCBI_TaxID=1220926 {ECO:0000313|EMBL:EPB85896.1, ECO:0000313|Proteomes:UP000014254};
RN   [1] {ECO:0000313|Proteomes:UP000014254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1006PhL {ECO:0000313|Proteomes:UP000014254};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., Earl A., Findley K., Lee S.C., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome sequence of Mucor circinelloides f. circinelloides 1006PhL.";
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the sepiapterin reductase family.
CC       {ECO:0000256|ARBA:ARBA00010483}.
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DR   EMBL; KE124001; EPB85896.1; -; Genomic_DNA.
DR   AlphaFoldDB; S2J713; -.
DR   STRING; 1220926.S2J713; -.
DR   VEuPathDB; FungiDB:HMPREF1544_07312; -.
DR   eggNOG; KOG1204; Eukaryota.
DR   InParanoid; S2J713; -.
DR   OMA; MTVQVQR; -.
DR   OrthoDB; 64672at2759; -.
DR   Proteomes; UP000014254; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004757; F:sepiapterin reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006729; P:tetrahydrobiopterin biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   InterPro; IPR006393; Sepiapterin_red.
DR   NCBIfam; TIGR01500; sepiapter_red; 1.
DR   PANTHER; PTHR44085; SEPIAPTERIN REDUCTASE; 1.
DR   PANTHER; PTHR44085:SF2; SEPIAPTERIN REDUCTASE; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014254}.
SQ   SEQUENCE   264 AA;  29294 MW;  890CBA44C4B8011B CRC64;
     MLLKHTVYII TGANRGFGKA IAETIASKVN QNRISFILVG RDQSQLESVK FDDNKFITCH
     YIANADFKGA KEAQVSVIDK ISSLIKAWQE NDTAPITNAV LINNAGSTGD LSKTVGDYDA
     SEIQDYVDLN ITSYISMVTG FIKLFNNGLI NTTIVNISSL LAVEAFPNWA LYATGKSARD
     MLLKVVTKEE PSIRTLSYAP GPLNNEMQQH VRETLGDQEQ KQLYTKMADE GNLVDMKDSA
     SRLYQLLAED KFESGSHVDY YDLE
//