ID S2JEQ9_MUCC1 Unreviewed; 659 AA.
AC S2JEQ9;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Phosphatidylinositol-glycan-specific phospholipase D {ECO:0000256|ARBA:ARBA00015988};
DE EC=3.1.4.50 {ECO:0000256|ARBA:ARBA00012284};
DE AltName: Full=Glycosyl-phosphatidylinositol-specific phospholipase D {ECO:0000256|ARBA:ARBA00029753};
GN ORFNames=HMPREF1544_06260 {ECO:0000313|EMBL:EPB86937.1};
OS Mucor circinelloides f. circinelloides (strain 1006PhL) (Mucormycosis
OS agent) (Calyptromyces circinelloides).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX NCBI_TaxID=1220926 {ECO:0000313|EMBL:EPB86937.1, ECO:0000313|Proteomes:UP000014254};
RN [1] {ECO:0000313|Proteomes:UP000014254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1006PhL {ECO:0000313|Proteomes:UP000014254};
RG The Broad Institute Genomics Platform;
RA Cuomo C., Earl A., Findley K., Lee S.C., Walker B., Young S., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome sequence of Mucor circinelloides f. circinelloides 1006PhL.";
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-
CC myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + a
CC 1,2-diacyl-sn-glycero-3-phosphate + H(+); Xref=Rhea:RHEA:10832,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57997,
CC ChEBI:CHEBI:58608, ChEBI:CHEBI:58700; EC=3.1.4.50;
CC Evidence={ECO:0000256|ARBA:ARBA00034002};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the GPLD1 family.
CC {ECO:0000256|ARBA:ARBA00008652}.
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DR EMBL; KE123978; EPB86937.1; -; Genomic_DNA.
DR AlphaFoldDB; S2JEQ9; -.
DR STRING; 1220926.S2JEQ9; -.
DR VEuPathDB; FungiDB:HMPREF1544_06260; -.
DR eggNOG; KOG3637; Eukaryota.
DR InParanoid; S2JEQ9; -.
DR OMA; CGMTTHN; -.
DR OrthoDB; 1332649at2759; -.
DR Proteomes; UP000014254; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004621; F:glycosylphosphatidylinositol phospholipase D activity; IEA:UniProtKB-EC.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 2.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR001028; Gprt_PLipase_D.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR029002; PLPC/GPLD1.
DR PANTHER; PTHR23221; GLYCOSYLPHOSPHATIDYLINOSITOL PHOSPHOLIPASE D; 1.
DR PANTHER; PTHR23221:SF7; PHOSPHATIDYLINOSITOL-GLYCAN-SPECIFIC PHOSPHOLIPASE D; 1.
DR Pfam; PF01839; FG-GAP; 1.
DR Pfam; PF00882; Zn_dep_PLPC; 1.
DR PRINTS; PR00718; PHPHLIPASED.
DR SMART; SM00191; Int_alpha; 4.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR PROSITE; PS51470; FG_GAP; 2.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000014254};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 30..176
FT /note="Phospholipase C/D"
FT /evidence="ECO:0000259|Pfam:PF00882"
FT REPEAT 473..534
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 591..646
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 659 AA; 73294 MW; 33DD16F7C2CF5209 CRC64;
MLISKINACG IAVHNEVTFR SLENFIPKSP LQQLYKDDLL DSASYTQAGS FFPDWGYQCL
GNNQQSEDAH WPTFIKTAVN YIRETYPATQ FHTDTHVKGL ISFVFAIMSH GMADVKWHSL
SGLQDYFIVA MAKSDFHGNV EESHIAADAG AEFTLRHSNK LSYLNETWKV PVNDIIEVYK
RLYEPSGKRV PLASHIQYCM AAAFAASKID VEFGQLMFGY YGSKSPFLIE ELYDYYRGGI
EDLSGGVSDC YPELINAFEN GAEHGHPDTL CASYFFSTRK AETARTTSKR ATCLDHGFQS
PYRSNTKHSI NNIYQDYDAT TGVLTLTVNK TKQIQAVKHD DMLPHITTTV VSPTLNNNNY
KKHAAIQQPF GRPVFNSIPA TNAGKASINK HQCLSLHEEQ ESTSKITLTI PMSSSRVGHQ
IVSGHFSSIG TDDDPMDIAI SAPFYYEDGL QTGAVFLLNS NLQAANIDTD IRNVSHTILH
GDTHHGRFGW SMAVLDLNKD GIDDLAIATP FNDRVDVYFG QAHKGLSESS CTRIQLQSQG
SQGTVLAGID VDQDGFNDLV IGCPLCSVGN QPQAGKVSVY LNHENQLTQP HFVIENPDIH
AYDHFGESML VIQDTLLISA PSYSVDQMQR VGRVYAFDTS TYKLKWIITG TKEFQQYGK
//
