ID S2K1W4_MUCC1 Unreviewed; 1200 AA.
AC S2K1W4;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=IQ domain-containing protein containing GTPase activating protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=HMPREF1544_04035 {ECO:0000313|EMBL:EPB89168.1};
OS Mucor circinelloides f. circinelloides (strain 1006PhL) (Mucormycosis
OS agent) (Calyptromyces circinelloides).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX NCBI_TaxID=1220926 {ECO:0000313|EMBL:EPB89168.1, ECO:0000313|Proteomes:UP000014254};
RN [1] {ECO:0000313|Proteomes:UP000014254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1006PhL {ECO:0000313|Proteomes:UP000014254};
RG The Broad Institute Genomics Platform;
RA Cuomo C., Earl A., Findley K., Lee S.C., Walker B., Young S., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome sequence of Mucor circinelloides f. circinelloides 1006PhL.";
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KE123939; EPB89168.1; -; Genomic_DNA.
DR AlphaFoldDB; S2K1W4; -.
DR STRING; 1220926.S2K1W4; -.
DR VEuPathDB; FungiDB:HMPREF1544_04035; -.
DR eggNOG; KOG2128; Eukaryota.
DR InParanoid; S2K1W4; -.
DR OMA; CANKYYD; -.
DR OrthoDB; 12619at2759; -.
DR Proteomes; UP000014254; Unassembled WGS sequence.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR CDD; cd21206; CH_IQGAP; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR000593; RasGAP_C.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR14149:SF14; PATTERNED EXPRESSION SITE; 1.
DR PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 1.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF03836; RasGAP_C; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF143885; RGC domain-like; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50096; IQ; 2.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000014254}.
FT DOMAIN 66..172
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 547..775
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 244..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1200 AA; 138787 MW; D880ED192D7207DB CRC64;
MALQPTPLNR LSVMAGKKGL TDLHIPTITE DAQDVVGRIR LQKDDKIQNS QWMDKQRNNL
LAYEYLCHIG EAKEWIEDCL QDEIDPIIKL EESMRNGIVL AKLADWFAPG IVRKIFQDTK
LQFRHSDNIN YFFEALKVAR LPQIFWFELT DLYEKKNIPK VIYCIHALSH LLSRRNLAPN
IKNLLGQLQF TNEELSATQR HLDMSGITMP NFMNVGSSLR RELNELEDED YITNVPDLII
EEEEEEEYLS DSEQSQSSIE SATEEEKFER YWSDKGNQDR LRVCQSIART FIARKEFNQV
HELHHSNEFV SLMTQLQAYI KGNLARNRLA HLKASYASRS TFAVQLQSAC RGYLSRIQYK
RTMDHYKANI EKVIKVQSFV KNKLVENAYR KLTTDSNPTI NTVKSFIHLL DDSDLDFDRE
LALEDLRQQV IENIKDNNNL DAHINSLDIQ IALFLKNAIT IDEVLKHSGA FKKKKEQQRM
ISEIAVNNQH SNPFSLAGID KESRQRLELY QQLIYLLQTE PKYLARLLSM TNRQDLGDYS
SHKLIESTVL SLFGYATNAR EEYLLVNLCK YCIAEEMKDV ESTLEFMRGN YTFMKLVVQT
NRGAKEREFF RTLLSPLVNE VVQNDFLDLE TDPVSIYHKA INDEESRTGM PSNRPHAVTS
QEALADVEVR DTFVIHLRNL REITEKFFAA VTSTVDTVPY GIRVVARELR LILEENFSSE
PHERIIRIIG NFIYYRYLNP AIVAPEQYDV IDAVISPMQR KNLAEVSKML QHISSGSVFE
DAHDIFLAPL NEYVADAGQR FGEWFLALTD VEDPESYFGM HALTDQTNTH KPIVYLSPNE
LFHLHYTLQT NLDTLEPEGA GILHDIVNEI GPSAYHPDIE LPESMVCLTL TNRCDNIPMD
PTARLQQLLV DTKRLVVYVI KIQTGRDLAH IFQTPITPES EAAWNQLKHK EFAETKEDYA
IVSKRRLLQL GQSEPPLDLQ TISFFQLKSI ANRLVVHLER CKVIASNNAY QDVINMIARD
ITGKNTRRMQ RDRELARMKL TLSHLQEKRD YLLEQGNSYE GYLNSCMTAM ATKKGKKQKF
IFPFTRQYFH MRGLQKLGLV PKFGSYKYTA KQLHERKVLL ELMDIPKRHY DRIPIILSMD
QAGIITIEGS YSGWPMSSVQ VDMRYEELLQ TQFEGVQTVT VLDGMAKVNV NLLIYLINKK
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