ID S2K6K9_MUCC1 Unreviewed; 532 AA.
AC S2K6K9;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=WD40 repeat-containing protein SMU1 {ECO:0000256|ARBA:ARBA00026184};
GN ORFNames=HMPREF1544_02117 {ECO:0000313|EMBL:EPB91048.1};
OS Mucor circinelloides f. circinelloides (strain 1006PhL) (Mucormycosis
OS agent) (Calyptromyces circinelloides).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX NCBI_TaxID=1220926 {ECO:0000313|EMBL:EPB91048.1, ECO:0000313|Proteomes:UP000014254};
RN [1] {ECO:0000313|Proteomes:UP000014254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1006PhL {ECO:0000313|Proteomes:UP000014254};
RG The Broad Institute Genomics Platform;
RA Cuomo C., Earl A., Findley K., Lee S.C., Walker B., Young S., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome sequence of Mucor circinelloides f. circinelloides 1006PhL.";
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
CC -!- SIMILARITY: Belongs to the WD repeat SMU1 family.
CC {ECO:0000256|ARBA:ARBA00025801}.
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DR EMBL; KE123913; EPB91048.1; -; Genomic_DNA.
DR AlphaFoldDB; S2K6K9; -.
DR STRING; 1220926.S2K6K9; -.
DR VEuPathDB; FungiDB:HMPREF1544_02117; -.
DR eggNOG; KOG0266; Eukaryota.
DR InParanoid; S2K6K9; -.
DR OMA; EYRGWTA; -.
DR OrthoDB; 74019at2759; -.
DR Proteomes; UP000014254; Unassembled WGS sequence.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR006595; CTLH_C.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR006594; LisH.
DR InterPro; IPR045184; SMU1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR22848; WD40 REPEAT PROTEIN; 1.
DR PANTHER; PTHR22848:SF1; WD40 REPEAT-CONTAINING PROTEIN SMU1; 1.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00668; CTLH; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50897; CTLH; 1.
DR PROSITE; PS50896; LISH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 7.
DR PROSITE; PS50294; WD_REPEATS_REGION; 6.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Reference proteome {ECO:0000313|Proteomes:UP000014254};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 58..112
FT /note="CTLH"
FT /evidence="ECO:0000259|PROSITE:PS50897"
FT REPEAT 236..278
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 279..320
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 324..365
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 366..407
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 408..449
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 467..493
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 494..525
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 532 AA; 60273 MW; 44B2E00D2F57DC93 CRC64;
MQNSHIQPTD DIFNSNDPRI KEDIIAIIMQ YLQDEGYHAS QSVLYDETNV KWKEREERTL
EVKRLKKAIL DGDWQEVEKL CTKPLVKNHR SFLYSVYKQQ YLEYLERREI QKAFTFLNKR
LKPLEHFQTK PNEFKDMCYL LTAKSIHEAP SFKQWEGIMA SRESLVDQLQ SMLEFETADR
TGNRHIPPDR LLGLLRQAVA YQIEFSRYHP KIAPTVNSLL DDYTSFVIPN AVGATLTGHQ
GNVKCLEFIG EEGKKIVSGS SDNTLRIWDT ESAKCLDVLE GHRSRIWDLT TTHAGDFVAS
ASGDSTVKIW NLKSQQKASC ATTLNGHAGD VYSVRYHPNE SHIVTGGYDK TVRLFDVNTG
AIIKTFPGHQ LAVTKTIFNP LGNLVISGSK DNTIKFWDIV SGLCIRTISS HLGEVTSVEM
NSSGTLLLSS SKDNSNRLWD VRMVRPIRKL KGHQNTSKNF VRANFADNNL IVGGSEDGIV
YIWDQETGEV LQKLRGHSGV VYDAAWNAKQ GMLASCSDDQ TVKVWWYDDA VS
//
