GenomeNet

Database: UniProt
Entry: S2KFC6_MUCC1
LinkDB: S2KFC6_MUCC1
Original site: S2KFC6_MUCC1 
ID   S2KFC6_MUCC1            Unreviewed;       366 AA.
AC   S2KFC6;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   24-JAN-2024, entry version 42.
DE   RecName: Full=rhizopuspepsin {ECO:0000256|ARBA:ARBA00013205};
DE            EC=3.4.23.21 {ECO:0000256|ARBA:ARBA00013205};
GN   ORFNames=HMPREF1544_02124 {ECO:0000313|EMBL:EPB91055.1};
OS   Mucor circinelloides f. circinelloides (strain 1006PhL) (Mucormycosis
OS   agent) (Calyptromyces circinelloides).
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC   Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX   NCBI_TaxID=1220926 {ECO:0000313|EMBL:EPB91055.1, ECO:0000313|Proteomes:UP000014254};
RN   [1] {ECO:0000313|Proteomes:UP000014254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1006PhL {ECO:0000313|Proteomes:UP000014254};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., Earl A., Findley K., Lee S.C., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome sequence of Mucor circinelloides f. circinelloides 1006PhL.";
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of proteins with broad specificity similar to that
CC         of pepsin A, preferring hydrophobic residues at P1 and P1'. Clots
CC         milk and activates trypsinogen. Does not cleave 4-Gln-|-His-5, but
CC         does cleave 10-His-|-Leu-11 and 12-Val-|-Glu-13 in B chain of
CC         insulin.; EC=3.4.23.21; Evidence={ECO:0000256|ARBA:ARBA00001130};
CC   -!- SIMILARITY: Belongs to the peptidase A1 family.
CC       {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KE123913; EPB91055.1; -; Genomic_DNA.
DR   AlphaFoldDB; S2KFC6; -.
DR   STRING; 1220926.S2KFC6; -.
DR   MEROPS; A01.A66; -.
DR   VEuPathDB; FungiDB:HMPREF1544_02124; -.
DR   eggNOG; KOG1339; Eukaryota.
DR   InParanoid; S2KFC6; -.
DR   OrthoDB; 4946at2759; -.
DR   Proteomes; UP000014254; Unassembled WGS sequence.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd05471; pepsin_like; 1.
DR   Gene3D; 2.40.70.10; Acid Proteases; 2.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR001969; Aspartic_peptidase_AS.
DR   InterPro; IPR034164; Pepsin-like_dom.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR   PANTHER; PTHR47966:SF51; NAPSIN-A; 1.
DR   Pfam; PF00026; Asp; 1.
DR   PRINTS; PR00792; PEPSIN.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   PROSITE; PS00141; ASP_PROTEASE; 2.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   3: Inferred from homology;
KW   Aspartyl protease {ECO:0000256|ARBA:ARBA00022750,
KW   ECO:0000256|RuleBase:RU000454};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR601461-2};
KW   Hydrolase {ECO:0000256|RuleBase:RU000454};
KW   Protease {ECO:0000256|RuleBase:RU000454};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014254}.
FT   DOMAIN          44..362
FT                   /note="Peptidase A1"
FT                   /evidence="ECO:0000259|PROSITE:PS51767"
FT   ACT_SITE        62
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   ACT_SITE        247
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   DISULFID        75..79
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ   SEQUENCE   366 AA;  39595 MW;  3B04D37EAA1E92A0 CRC64;
     MNTPARVKRA LAKYGIVDEK INSRLNSASN AAIELFSAYV DIEYIGEIAI GTPPQKFNVD
     FDTGSSDIWV PSSRCGSSCS THHRFDGSKS STYKEMGNKT WHLSYGDGSS VRGYTALDAV
     HLGNVTQPQQ LIGLVTQQTP EFASDKFLDG IFGLAFPPLA YTGIKASIVE DLHMAGSIPS
     PIVSFHLGHS RDGGKGEILF GDINQNHFEG ELKYVPVTVK KYWQVDMTGV EVGGTNVLAS
     TMPAIVDTGT TLIIVPSAVS KAIHKAIPGA EYDPMYGWRI PCAFADDSST ESINIKLGDQ
     DFPLYLRDLV RAKASQSLST GKSRLCYSGV AEANTPLVIL GDTFLRSYYS VYDFGNARVG
     LARAKP
//
DBGET integrated database retrieval system