ID S2KKK4_MUCC1 Unreviewed; 567 AA.
AC S2KKK4;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Eukaryotic translation initiation factor 2A {ECO:0000256|ARBA:ARBA00013819, ECO:0000256|PIRNR:PIRNR017222};
DE Short=eIF-2A {ECO:0000256|PIRNR:PIRNR017222};
GN ORFNames=HMPREF1544_00359 {ECO:0000313|EMBL:EPB92920.1};
OS Mucor circinelloides f. circinelloides (strain 1006PhL) (Mucormycosis
OS agent) (Calyptromyces circinelloides).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX NCBI_TaxID=1220926 {ECO:0000313|EMBL:EPB92920.1, ECO:0000313|Proteomes:UP000014254};
RN [1] {ECO:0000313|Proteomes:UP000014254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1006PhL {ECO:0000313|Proteomes:UP000014254};
RG The Broad Institute Genomics Platform;
RA Cuomo C., Earl A., Findley K., Lee S.C., Walker B., Young S., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome sequence of Mucor circinelloides f. circinelloides 1006PhL.";
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions in the early steps of protein synthesis of a small
CC number of specific mRNAs. Acts by directing the binding of methionyl-
CC tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it
CC binds methionyl-tRNAi to 40S subunits in a codon-dependent manner,
CC whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a
CC GTP-dependent manner. {ECO:0000256|PIRNR:PIRNR017222}.
CC -!- SIMILARITY: Belongs to the WD repeat EIF2A family.
CC {ECO:0000256|ARBA:ARBA00009573, ECO:0000256|PIRNR:PIRNR017222}.
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DR EMBL; KE123897; EPB92920.1; -; Genomic_DNA.
DR AlphaFoldDB; S2KKK4; -.
DR STRING; 1220926.S2KKK4; -.
DR VEuPathDB; FungiDB:HMPREF1544_00359; -.
DR eggNOG; KOG2315; Eukaryota.
DR InParanoid; S2KKK4; -.
DR OMA; MQARWPA; -.
DR OrthoDB; 22264at2759; -.
DR Proteomes; UP000014254; Unassembled WGS sequence.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011387; TIF2A.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13227; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR PANTHER; PTHR13227:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR Pfam; PF08662; eIF2A; 1.
DR PIRSF; PIRSF017222; eIF2A; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000256|PIRNR:PIRNR017222};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|PIRNR:PIRNR017222};
KW Reference proteome {ECO:0000313|Proteomes:UP000014254};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845,
KW ECO:0000256|PIRNR:PIRNR017222}.
FT DOMAIN 213..406
FT /note="Translation initiation factor beta propellor-like"
FT /evidence="ECO:0000259|Pfam:PF08662"
FT REGION 434..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 480..513
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 567 AA; 63496 MW; 0934E951C1931752 CRC64;
MSTNKPITQF SFRSQKELTI WDGYPEFKAV SNFEKPDTTT RMFHYSRYGH VYAYSTNLSV
KVFDASTMEQ LCEIERANVI DFWLSPQGSY LATWERPTKL ENGAGSNNLV IWDTKTGQEI
AAFSQKAQNN WNFQWTDDEK YCARMVTGEV QFWESKNIGK SVWARLKLEG VAQFSLSPGK
APAVAVFIPE KNGAPAIVRM YSIPNFNTAL SNKTFYKADR ISMYWNDLGT NLLVLTMTDV
DKSNKSYYGE TNLYYLAVAG NFDCRVPLDK EGPIHDVTWG PDSKEFVVVY GSMPAKATLF
DHRATPVFDF GINPRNFVKY NPQGRTICIA GFGNLNGTVD LWDRKTLKKI NTFAASNASH
CEWSPCGRYL LTATLTPRLR VDNGFKLWHH SGTLIYEEAV DELYQIGYRP EPAARYPMRN
VSPPPNPIKI LPTAGGGAKA SAVPTGAYRP PHLRGSATPT SLSDRAAALD GIGRSPTSQR
RVVGAKSGNN ANNKNGKKDV SSPKPQAQQP VVNPEEKQKK IRNLEKKLRQ IRELKDKMAK
GEELAPAQQQ KVTTEVAVMR ELANLQL
//
