ID S2NUG6_LACPA Unreviewed; 860 AA.
AC S2NUG6;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=Lpp225_0964 {ECO:0000313|EMBL:EPC38331.1};
OS Lacticaseibacillus paracasei subsp. paracasei Lpp225.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lacticaseibacillus.
OX NCBI_TaxID=1256225 {ECO:0000313|EMBL:EPC38331.1, ECO:0000313|Proteomes:UP000014270};
RN [1] {ECO:0000313|EMBL:EPC38331.1, ECO:0000313|Proteomes:UP000014270}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Lpp225 {ECO:0000313|EMBL:EPC38331.1,
RC ECO:0000313|Proteomes:UP000014270};
RX PubMed=23894338;
RA Smokvina T., Wels M., Polka J., Chervaux C., Brisse S., Boekhorst J.,
RA van Hylckama Vlieg J.E., Siezen R.J.;
RT "Lactobacillus paracasei comparative genomics: towards species pan-genome
RT definition and exploitation of diversity.";
RL PLoS ONE 8:E68731-E68731(2013).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPC38331.1}.
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DR EMBL; ANMM01000006; EPC38331.1; -; Genomic_DNA.
DR AlphaFoldDB; S2NUG6; -.
DR PATRIC; fig|1256225.3.peg.1003; -.
DR Proteomes; UP000014270; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}.
FT DOMAIN 685..701
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 611..618
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 860 AA; 95180 MW; 9C67E232C70418CC CRC64;
MNFVPQKTSE TPMMQQYNEI KAQYPDAFLF YRIGDFYELF NDDAIKGAQL LELTLTARNK
SADDPIPMAG VPHHAVQSYV DILIDHGYKV AICEQMEDPK KAVGMVKRAV IQLVTPGTNV
DIKAGAAKSN NYITAVMPHA AGYAFAYADV STGELKVTDL KSKFALQNEL SALATKEIVV
PEELTDDDAG MLKQGERLLS VQPDAEPTSE GSYVSQALTD PAEAAVVQML MAYLLNTQKR
SLAHIQKAVA YQPSAYLEMD QDARNNLDIL QNSRTGRKGD TLLSLLDSTK TAMGGRLLKQ
WLDRPLLDID AISVRQNQVQ DLLDHFFERS ELQERLTKVY DLERLAGRVA FGTVNGRDLI
QLQTSLDQIP AIQDVLGKLD DGSFKALRSK MDPVSDVAGL IRRAIEPEPP ISVTDGGLIL
RGYNQKLDSY RDAMKNSKQW IAELEASERK ATGIHTLKIR YNKVFGYFIE VTKSNLDKIP
EGRYERKQTL TNAERFITPE LKEKETLILE AQESSTALEY DLFQDIRDKV KAQIKRLQAL
AAQISSLDVL QSFATVAENS HYVRPTMHAG THDINVKGGR HPVVEHVLGR DSYIPNDVIM
NHDTDMLLIT GPNMSGKSTY MRQLALIVIM AQAGSFVPAD VADLPIFDQI FTRIGAADDL
ANGESTFMVE MLEANAALSH ATASSLILFD EIGRGTATYD GMALAQAIIE FLHDHVHAKT
LFSTHYHELT SLSDSLAKLK NVHVGAVEEH GNLVFLHKMM PGPADKSYGI HVAKLAGLPA
DLLARADTIL KQLEADAPNK TAPAPAPQVE EQQLSLFEEP KPTPKNSPIL TKLAKFDLMA
ATPMDAMNFI FDLQKHLKKK
//
