ID S2SFK7_LACPA Unreviewed; 343 AA.
AC S2SFK7;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=mannonate dehydratase {ECO:0000256|ARBA:ARBA00012927};
DE EC=4.2.1.8 {ECO:0000256|ARBA:ARBA00012927};
DE Flags: Fragment;
GN ORFNames=Lpp126_06690 {ECO:0000313|EMBL:EPC78253.1};
OS Lacticaseibacillus paracasei subsp. paracasei Lpp126.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lacticaseibacillus.
OX NCBI_TaxID=1256206 {ECO:0000313|EMBL:EPC78253.1, ECO:0000313|Proteomes:UP000014243};
RN [1] {ECO:0000313|EMBL:EPC78253.1, ECO:0000313|Proteomes:UP000014243}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Lpp126 {ECO:0000313|EMBL:EPC78253.1,
RC ECO:0000313|Proteomes:UP000014243};
RX PubMed=23894338;
RA Smokvina T., Wels M., Polka J., Chervaux C., Brisse S., Boekhorst J.,
RA van Hylckama Vlieg J.E., Siezen R.J.;
RT "Lactobacillus paracasei comparative genomics: towards species pan-genome
RT definition and exploitation of diversity.";
RL PLoS ONE 8:E68731-E68731(2013).
CC -!- FUNCTION: Catalyzes the dehydration of D-mannonate.
CC {ECO:0000256|ARBA:ARBA00002713}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O;
CC Xref=Rhea:RHEA:20097, ChEBI:CHEBI:15377, ChEBI:CHEBI:17767,
CC ChEBI:CHEBI:57990; EC=4.2.1.8;
CC Evidence={ECO:0000256|ARBA:ARBA00001794};
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC interconversion. {ECO:0000256|ARBA:ARBA00004892}.
CC -!- SIMILARITY: Belongs to the mannonate dehydratase family.
CC {ECO:0000256|ARBA:ARBA00007389}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPC78253.1}.
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DR EMBL; ANKC01000473; EPC78253.1; -; Genomic_DNA.
DR AlphaFoldDB; S2SFK7; -.
DR UniPathway; UPA00246; -.
DR Proteomes; UP000014243; Unassembled WGS sequence.
DR GO; GO:0008927; F:mannonate dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.150; Divalent-metal-dependent TIM barrel enzymes; 1.
DR HAMAP; MF_00106; UxuA; 1.
DR InterPro; IPR004628; Man_deHydtase.
DR InterPro; IPR036237; Xyl_isomerase-like_sf.
DR PANTHER; PTHR30387; MANNONATE DEHYDRATASE; 1.
DR PANTHER; PTHR30387:SF2; MANNONATE DEHYDRATASE; 1.
DR Pfam; PF03786; UxuA; 1.
DR PIRSF; PIRSF016049; Man_dehyd; 1.
DR SUPFAM; SSF51658; Xylose isomerase-like; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:EPC78253.1};
KW Manganese {ECO:0000256|ARBA:ARBA00023211}.
FT NON_TER 343
FT /evidence="ECO:0000313|EMBL:EPC78253.1"
SQ SEQUENCE 343 AA; 39910 MW; 9C18E1775E424D89 CRC64;
MSDLKMGFRW FGEKDDPITL QQIRQIPGTQ QVVGALYDVP VGEVWPKEKI AALKKQVEDA
GLKLEVIESV NIHDDIKIGL PSRDKYIENY KETIKNLSEY GIKVICYNFM PIFDWLRTNL
HYQLEDGSNV MAFQHQYLKD DPHDIIESVR NNSEGYVLPG WEPERLAEIE RLFKAYADVD
AAKLRENMKY FLDAIIPTCE QYDVRMAMHP DDPPRELFDL PRVYKNAEDM RIIEAMHESR
YNGFTICTGS LGENPKNDVP AIIREFVKKD RAPFIHARNI KFMNKEGDFH ESDHLSKDGS
LDMYEIMKAL HDLDYDGYIR PDHGRNIWGE NGRPGYGLYD RAL
//
