ID S2W665_9ACTN Unreviewed; 563 AA.
AC S2W665;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=AMP-dependent synthetase/ligase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=HMPREF9306_00473 {ECO:0000313|EMBL:EPD33715.1};
OS Propionimicrobium lymphophilum ACS-093-V-SCH5.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Propionibacteriaceae; Propionimicrobium.
OX NCBI_TaxID=883161 {ECO:0000313|EMBL:EPD33715.1, ECO:0000313|Proteomes:UP000014417};
RN [1] {ECO:0000313|EMBL:EPD33715.1, ECO:0000313|Proteomes:UP000014417}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ACS-093-V-SCH5 {ECO:0000313|EMBL:EPD33715.1,
RC ECO:0000313|Proteomes:UP000014417};
RG The Broad Institute Genomics Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Saerens B., Vaneechoutte M.,
RA Walker B., Young S., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Allen A.W., Alvarado L., Arachchi H.M., Berlin A.M.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Propionimicrobium lymphophilum ACS-093-V-SCH5.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPD33715.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AGZR01000004; EPD33715.1; -; Genomic_DNA.
DR RefSeq; WP_016455323.1; NZ_KE150269.1.
DR AlphaFoldDB; S2W665; -.
DR STRING; 883161.HMPREF9306_00473; -.
DR PATRIC; fig|883161.3.peg.479; -.
DR HOGENOM; CLU_000022_59_9_11; -.
DR OrthoDB; 9803968at2; -.
DR Proteomes; UP000014417; Unassembled WGS sequence.
DR GO; GO:0016877; F:ligase activity, forming carbon-sulfur bonds; IEA:UniProt.
DR CDD; cd05936; FC-FACS_FadD_like; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43767; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR PANTHER; PTHR43767:SF1; NONRIBOSOMAL PEPTIDE SYNTHASE PES1 (EUROFUNG)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000014417}.
FT DOMAIN 36..424
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 474..549
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 563 AA; 62383 MW; D48ED470335131F2 CRC64;
MRQRRNLKPD PAWTKHYQHG VKPRIIPPTE SLAEMFARSV QQAGKKTATV FFDAKTSYKA
LGDQVSRAAN SLRRMGVRPG DRVAVLLPNC PQHLVAMYAI WRIGAVLVEH NPLYTQPELE
TMFADHDARV AIAMDSVVPK LKKMPRNVRP RTIVSVNLLH ALPKLKRMAL SLPLPKLRKM
RAQLSSGDRG SVTWEEMLSA KPISNRVPYP QVNSLAAIQY TSGTTGKPKG AMLTHFNLYS
NALQGAAWMR GAETGKETSY AALPMFHSFG ITMHATFGVL KQMRQVLFPK PDTDLIVSAM
KKYPATVYCV VPILYQRTAE TARKRGVSLK SCKYCISGAA ALPDSTRTLW EKVSGGLLVE
GYGLTEASPV ALGNPFWKSR RPGTIGIPFP STLMKVVDDE GNQVSPNTPG ELLLQGPQIT
QGYWHDREAT EQVLKDGWLH TGDVVTADED GFVTIVARKK EIIVTGGFNV SPAEVEEVLN
SHEGIVESCV VGLPTERGDE EVVAAVVLKR DVKLDTEETR NWLKKQLAAY KVPRKFFPVD
EIPKSMLGKA LRKQTRDQIL SNL
//
