ID   S2X1L8_9ACTN            Unreviewed;       650 AA.
AC   S2X1L8;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=Beta-lactamase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=HMPREF9306_00144 {ECO:0000313|EMBL:EPD33919.1};
OS   Propionimicrobium lymphophilum ACS-093-V-SCH5.
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Propionibacteriaceae; Propionimicrobium.
OX   NCBI_TaxID=883161 {ECO:0000313|EMBL:EPD33919.1, ECO:0000313|Proteomes:UP000014417};
RN   [1] {ECO:0000313|EMBL:EPD33919.1, ECO:0000313|Proteomes:UP000014417}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ACS-093-V-SCH5 {ECO:0000313|EMBL:EPD33919.1,
RC   ECO:0000313|Proteomes:UP000014417};
RG   The Broad Institute Genomics Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Saerens B., Vaneechoutte M.,
RA   Walker B., Young S., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA   Abouelleil A., Allen A.W., Alvarado L., Arachchi H.M., Berlin A.M.,
RA   Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA   Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA   Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA   Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Propionimicrobium lymphophilum ACS-093-V-SCH5.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the transpeptidase family.
CC       {ECO:0000256|ARBA:ARBA00007171}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EPD33919.1}.
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DR   EMBL; AGZR01000002; EPD33919.1; -; Genomic_DNA.
DR   RefSeq; WP_016455005.1; NZ_KE150269.1.
DR   AlphaFoldDB; S2X1L8; -.
DR   STRING; 883161.HMPREF9306_00144; -.
DR   HOGENOM; CLU_025328_0_0_11; -.
DR   OrthoDB; 5241017at2; -.
DR   Proteomes; UP000014417; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF24; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE PBPA; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014417};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           26..650
FT                   /note="Beta-lactamase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004502928"
FT   DOMAIN          165..317
FT                   /note="Penicillin-binding protein dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          384..624
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
SQ   SEQUENCE   650 AA;  68162 MW;  EAE06A298C01CC8A CRC64;
     MAQKIFSRLA AAALACLFIA GCSKPGYTPP DGAEEIGEAL ANVLASGQFN GLQVAGDTQA
     AEADFDEVIA GMQGLRPEVK VGEIKYEGTM ENPAAQVSLN QNYTFSRNVE PQDESASPEP
     TPSISRWAFT SKANLVYEGG WKVSWAPSIV HPQLDEYTRL VYERTSPKRG IITDRNGAAI
     VSEQPVYKVG VDKTKLNGAD GDESARRLAE LVKVDVDAYV SRFQASGPQA FVEALTVRSE
     KLPEGIEEIP GAIALGANMP LAPSENFAGN IFGTVGEATA EEIKNSDGLL SAGDQVGKQG
     LQKSADARLR GDTGHKISLK FRKSVSKQTQ EELAKPATPS AEPIVEADLF SLSPKGGEAV
     QTTLNMSIQT KLEAALAKSP GKIAVAVLDK DGGILAAGTS PDVGSQPLAT VGQFPPGSTM
     KVASSLALLR RGEKPTSKVD CSEKAEAGGR EFTNYPGYPK VFIGKISLAN ALAQSCNTAF
     VNAKITSKEL SSAAASLGMG VDYDAGFDSF YGSVPATEDP VVAAANSFGQ GHVLVSPMAL
     AAMSGSVNSG KSLVAHLRTD VVPTLDASPI TEDEAAQLKE MMEGVLKGTG SSYAKWLSGA
     KTGTAEFEEG SETKTHIWVT GFSGDMSVAI IDYDAKDGKN FEPILTAIFK
//