ID S2Y9C4_9ACTN Unreviewed; 655 AA.
AC S2Y9C4;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Acetoacetate-CoA ligase {ECO:0000313|EMBL:EPD61153.1};
GN ORFNames=HMPREF1211_04178 {ECO:0000313|EMBL:EPD61153.1};
OS Streptomyces sp. HGB0020.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1078086 {ECO:0000313|EMBL:EPD61153.1, ECO:0000313|Proteomes:UP000014410};
RN [1] {ECO:0000313|EMBL:EPD61153.1, ECO:0000313|Proteomes:UP000014410}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HGB0020 {ECO:0000313|EMBL:EPD61153.1,
RC ECO:0000313|Proteomes:UP000014410};
RG The Broad Institute Genomics Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Schmidt T.M., Dai D., Dover J.,
RA Kim K., Walker B., Young S., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Allen A.W., Alvarado L., Arachchi H.M., Berlin A.M.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Streptomyces sp. HGB0020.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPD61153.1}.
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DR EMBL; AGER01000016; EPD61153.1; -; Genomic_DNA.
DR RefSeq; WP_016434127.1; NZ_KE150427.1.
DR AlphaFoldDB; S2Y9C4; -.
DR STRING; 1078086.HMPREF1211_04178; -.
DR PATRIC; fig|1078086.3.peg.4224; -.
DR HOGENOM; CLU_000022_3_3_11; -.
DR OrthoDB; 9803968at2; -.
DR Proteomes; UP000014410; Unassembled WGS sequence.
DR GO; GO:0030729; F:acetoacetate-CoA ligase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd05943; AACS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR005914; Acac_CoA_synth.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR01217; ac_ac_CoA_syn; 1.
DR PANTHER; PTHR42921; ACETOACETYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR42921:SF1; ACETOACETYL-COA SYNTHETASE; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:EPD61153.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000014410}.
FT DOMAIN 41..97
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 99..472
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 539..614
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 655 AA; 72158 MW; A59A475BCF98E400 CRC64;
MSTVNPQPLW LPDPERVAQA QVTKFQAWAA EHHGAPADGG YEALHRWSVD ELDTFWKAVT
EWFDVRFSTP YARVLGDRSM PGAQWFPGAS LNYAEHALRA AAARADEPAL LCVDETHEPR
PVTWAELRRQ VGSLAAELRA RGVRPGDRVS GYLPNIPQAV VAFLATAAVG GVWTSCAPDF
GARSVLDRFQ QVEPVVLFTV DGYRYGGKEH DRRDVVAELR RELPTLRDVV HIPLLGTQTP
EGAVAWSALT GADVEPVFEQ VPFDHPLWVL YSSGTTGLPK AIVQSQGGIL VEHLKQLGLH
CDLGSEDRFF WYTSTGWMMW NFLVSGLLTG TTIVLYDGSP GFPDTGAQWR VAERTGATLY
GTSAAYVMAC RKADVHPARD FDLSKVACVA TTGSPLPPDG FRWLHDEVRD DLWIASVSGG
TDVCSCFAGA VPTLPVHVGE LQAPSLGTDL QSWDPSGKPL VDEVGELVVT NPMPSMPIHF
WNDPDGSRYH DSYFSTYPGV WRHGDWITVT SRGSVVIHGR SDSTLNRQGV RMGSADIYEA
VERIPEIKES LVIGIEQPDG GYWMPLFVHL APGATLDEAL LDRVRRTIRE QLSPRHVPDE
IIEVPGIPHT LTGKRIEVPV KRLLQGTPLE KAVNPGSIDN LDLLHFYEDL ARKRA
//
