ID S2YHW2_9ACTN Unreviewed; 495 AA.
AC S2YHW2;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Aldehyde dehydrogenase domain-containing protein {ECO:0000259|Pfam:PF00171};
GN ORFNames=HMPREF1211_02983 {ECO:0000313|EMBL:EPD63856.1};
OS Streptomyces sp. HGB0020.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1078086 {ECO:0000313|EMBL:EPD63856.1, ECO:0000313|Proteomes:UP000014410};
RN [1] {ECO:0000313|EMBL:EPD63856.1, ECO:0000313|Proteomes:UP000014410}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HGB0020 {ECO:0000313|EMBL:EPD63856.1,
RC ECO:0000313|Proteomes:UP000014410};
RG The Broad Institute Genomics Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Schmidt T.M., Dai D., Dover J.,
RA Kim K., Walker B., Young S., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Allen A.W., Alvarado L., Arachchi H.M., Berlin A.M.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Streptomyces sp. HGB0020.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|RuleBase:RU003345}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPD63856.1}.
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DR EMBL; AGER01000012; EPD63856.1; -; Genomic_DNA.
DR RefSeq; WP_016432937.1; NZ_KE150427.1.
DR AlphaFoldDB; S2YHW2; -.
DR STRING; 1078086.HMPREF1211_02983; -.
DR PATRIC; fig|1078086.3.peg.3023; -.
DR HOGENOM; CLU_005391_0_2_11; -.
DR OrthoDB; 6882680at2; -.
DR Proteomes; UP000014410; Unassembled WGS sequence.
DR GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR PANTHER; PTHR11699:SF211; ALDEHYDE DEHYDROGENASE FAMILY 16 MEMBER A1; 1.
DR PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003345};
KW Reference proteome {ECO:0000313|Proteomes:UP000014410}.
FT DOMAIN 16..481
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 255
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 495 AA; 52316 MW; BF8EC1A58BA71B8C CRC64;
MPHIPADEIL IAGRWRRGRG LPIHTADPAD GTVLTTVHAA SVEDVEEAAC AAAGAAAAPE
WRDLLPHERA RVLHRIGDAI EERAEELSAL QTADTGKTLG ETRALALSAA GTFRYTAAAL
ETAEDALTPS RGPYLTMSVH EPIGVVGAIN PWNSPIASDA QKVAPALAGG NAVLLKPAEW
TPLVSLALGR IVHRVLAGAG LPTALLAVLP GKGSIVGDVI VRHPLVGRIG FTGGTGTGRG
IAHVAADKLI PASLELGGKS PTIVREDADV EQALAGVMYG IFSSSGQSCI AGSRLFVQAG
LYDTFVGELV ERIRKLRVGP GNSPDTQVAP LVHHRHRDAV AAYVDLAREE GGRVLCGGAA
PEGELYAKGA YYLPTVIDGL PNSARTCQEE IFGPVLVALR YDDEDELVAQ ANDSDFGLAC
GIWTRDARAA WRLGRRIDAG TVWINTYKQF SISTPFAGMK DSGLGTEKGR ELIRAYQRQK
SLYWGTDLAP LPWAN
//
