ID S2YMC2_9ACTN Unreviewed; 2653 AA.
AC S2YMC2;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Amino acid adenylation domain-containing protein {ECO:0000313|EMBL:EPD63270.1};
GN ORFNames=HMPREF1211_03611 {ECO:0000313|EMBL:EPD63270.1};
OS Streptomyces sp. HGB0020.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1078086 {ECO:0000313|EMBL:EPD63270.1, ECO:0000313|Proteomes:UP000014410};
RN [1] {ECO:0000313|EMBL:EPD63270.1, ECO:0000313|Proteomes:UP000014410}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HGB0020 {ECO:0000313|EMBL:EPD63270.1,
RC ECO:0000313|Proteomes:UP000014410};
RG The Broad Institute Genomics Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Schmidt T.M., Dai D., Dover J.,
RA Kim K., Walker B., Young S., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Allen A.W., Alvarado L., Arachchi H.M., Berlin A.M.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Streptomyces sp. HGB0020.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPD63270.1}.
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DR EMBL; AGER01000013; EPD63270.1; -; Genomic_DNA.
DR RefSeq; WP_016433564.1; NZ_KE150427.1.
DR STRING; 1078086.HMPREF1211_03611; -.
DR PATRIC; fig|1078086.3.peg.3656; -.
DR HOGENOM; CLU_000022_0_3_11; -.
DR OrthoDB; 2472181at2; -.
DR Proteomes; UP000014410; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd17646; A_NRPS_AB3403-like; 2.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR CDD; cd19540; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 3.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 3.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 7.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000014410}.
FT DOMAIN 1018..1093
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2060..2134
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 2042..2063
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2653 AA; 287367 MW; 2E353BE35406D09B CRC64;
MTQTHAGAPA DLAARKRELL RRRLETAGLA DTAARSEHIP PRPADAGRLP LSYAQSRMWL
LQQLDPDSPA YNVCLAIRLR GPLDSAALRT ALQGLVDRHE VLRTRYPATD DGVPEQVVDP
AAQVHFGTID LGELSEAEQE RQAVELARRE SATAFDLTAD HPLRALLIRR SDQDHTLVLT
VHHIAWDGGT FNALSRDLSA LYRAATTNTP AGLEPLPLQY ADFARWQRGT WTGERLAGHL
DHWRAALVPP PRPLALPTDA PRSARPTARG DRRFHTFAPD VTERLTAFAR NTGATPFMVL
LAGLSALLHR VTGATDIPVG SAVMSRDLPG LEKLVGNFGN TLALRADLDG DPAFGELVER
VKQLCTDAYA HQDMPFDRLV EELRPERQPG RSVYFDVMLL FLTQGLEGPR LPGVTAEWET
VHNDTTQFDL SLEAFLTGGH LRIEATYRSE LFTPDTVDRL LRHLETLLGA ALTDPELALS
RLPLMTDTEQ CVVLEEWNAT THPVPVTTLT ELLDRQPTRT PDAPALIAES TVLDHAELHA
RANRLARLLI AHGVGPEGLV GVALDRGPDL VVALLAVLKA GGAYLPLDTG YPAERLAFMI
EDSAPALVVT NRDTLPAHGA PELLLDDPAV TERLAAADAA QLTDPERLRP LRPDHPAYVI
YTSGSTGRPK GAVVSHAAIV NRLLWMRDTY GLEPGDRVLQ KTPASFDVSV WEFFWPLITG
AALVLARPGG HRDPGHLAEL IREQGVTTAH FVPSMLRVFL DDPAAEHVRG VLRRVVCSGE
ALPAELAERC TRVLDGTELH NLYGPTEAAV DVTAWPCAEG TRSAAGSVPI GRPVWNTRTL
VLDGSLRPVP AGVPGELYLG GTQLARGYLH RPGLTASRFV ADPYGPPGAR LYRTGDLVRW
TARGALEFLG RTDDQIKIRG FRVEPGETEA AAAALPGVSQ AAVTVRPEEA QLVAYVVPQP
GARLQPLQVR QDLTATLPDH LLPYAVVVLD ALPLTPNGKL DRAALPAPDL SDLTTATAPR
TEAEATLCAL FADLLGLPAV GVHDEFFALG GHSVLATRLV ARIRAELGIV VPLRAVFDTP
TPAALAPLLN APSDPRSELR PRERPGTIPL SSAQARLWFM YRLEGPSPTY NIHTALHLTG
RLDAEALRAA LNDVVARHES LRTVFPDDDG TPRQAVLPPQ DVTVPFAVVP ADAEELDDLM
RDAAGYCFAL DAEIPVRATL FSLAPDEHVL LLLVHHIATD GWSEQPLLTD LETAYTARLA
GAAPNWPPLP VQYADYTLWQ QRTETDDQLA YWQQALAGLP EELQLPVDRP RPAVAGHRAG
AVDFTLDAEV HALLRRLAAE TGGTTFMALQ AALAVLLGRL GAGDDIPLGS PVAGRGDPAL
DDLVGLFVNT LVLRTDISGN PTFRTLLARV READVDAYAH QDLPFEQLVD ALAPTRSMGR
HPLFQVMLAH QQAPDDTREF AGLALRELRV DLYTAKTDLA FHLFERAEAE GIDGSLVYSR
DLYDLGTAQD MTERFVRLVG ELARDPDRPV STADVLFPRE RSLLLGEWND TAHPMPAATL
TALVEEQAAR TPDLTAVEYG TEDGPSLTYA ELNARANALA ARLTSLGVGP ERRVGVHLER
SVEMVVGLLA ILKAGGAFVP LEPSWPARRI AEVCRSADLT AVLGSSGDAI EGPPVVEVDL
SGPVPDAADP GIAVDPESLA YVIHTSGSTG VPKGAMIRHR AITHRLLWQR GLLGFGPSDA
ALFKAPLGFD ISINEIFLPL VNGGRVVISE PGGERDVDYL LDTVERHRVT FTYLVSSMLD
LLLEQDGFAH RARSLKHVWC GGEVLTPELF ARFRAASPAV MYHGYGPAEA TIGVSHVVYR
TGAIRSAVSI GRPNGNTRLY VLDERLRPTP IGVPGELYAG GVYLGRGYVN DPRRTADHWV
ADPFGPPGER LYRTGDLVRW QRDGTLEFLG RADNQIKIRG MRVELEEIEA VLEQHPGVRR
AVVVLREDAP GVKQLAGYCL AARDPELLTD LRGWLQERLP EHMVPRTLTV LDAFPLLPSG
KVDRTSLPAP ESTATAATRE PANARERQLT ELFATVLGLA AVDVDANFFA LGGDSIVSIR
LVTLARKAGL AISPRQIFQT PTPAGLAAAA DNPERTAPAP ADDPLGELDL TPVMHWAAGP
GGSYDGLAQA VLLVTPPGLT HDRLTSVLRT VVNRHDMLRA RLTEQARLLV PEEAEVRVTR
VTGLPGDDLE RHLAAAADRL DPYTGHMLEA VWFEPEDFEP GDFEPGDFEL EDSKLEDSEL
GDFEPEDTAA GRLLLVAHHL VVDGVSWRIV CADLAEVWAG RSPSPRGTSF RTWSRLLAEE
ARKPARVREL PWWTEALTGA RPLLDRSPDP DRDTARTLRE HTLVLPADVT DPLLTTVPAA
YRAGVPDLLL TTLALAAAAR REEHGDLTNR SLLVGVEGHG REEGIADGVD LSSTVGWFTT
FHPVAVDPGP LDLDDALDGG ATAGVALKRV KEQLRAVPDH GLGYGLLRHL NPDTAPALEQ
LPQPQIVLNY LGRFTAADAG GQTGQSGQPW ELAPEAPMLR IPPSGDRPVP FALEINAVTV
ETGAGARLHI SAAWPDAFLD PDESGRLLAL WERALRGLAR HAEAAPAGGL TPSDLPLVEL
TQDDIDDFEN DTF
//
