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Database: UniProt
Entry: S2YWA2_9ACTN
LinkDB: S2YWA2_9ACTN
Original site: S2YWA2_9ACTN 
ID   S2YWA2_9ACTN            Unreviewed;       633 AA.
AC   S2YWA2;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   27-SEP-2017, entry version 32.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=HMPREF1211_07179 {ECO:0000313|EMBL:EPD56064.1};
OS   Streptomyces sp. HGB0020.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1078086 {ECO:0000313|EMBL:EPD56064.1, ECO:0000313|Proteomes:UP000014410};
RN   [1] {ECO:0000313|EMBL:EPD56064.1, ECO:0000313|Proteomes:UP000014410}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HGB0020 {ECO:0000313|EMBL:EPD56064.1,
RC   ECO:0000313|Proteomes:UP000014410};
RG   The Broad Institute Genomics Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Schmidt T.M., Dai D.,
RA   Dover J., Kim K., Walker B., Young S., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA   Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA   Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA   Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S.,
RA   Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Streptomyces sp. HGB0020.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EPD56064.1}.
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DR   EMBL; AGER01000030; EPD56064.1; -; Genomic_DNA.
DR   EnsemblBacteria; EPD56064; EPD56064; HMPREF1211_07179.
DR   PATRIC; fig|1078086.3.peg.7234; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000014410; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000014410};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014410}.
FT   DOMAIN      326    454       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      540    609       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     334    341       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   633 AA;  70616 MW;  FC8FFB999ABBF425 CRC64;
     METKDEHWIR RCQPLALVAD TALLAVPNEF AKGVLEGRLA PIVSETLSRE CGRPIRIAIT
     VDDSAGEPAG PPAPPARSQQ RYEEPELPSG QYEGYGRHRG DDHRPGRSEQ LPGAPGDQLP
     HPRPEQLPHP RTDQLPTARP AYPSEYQRPE PGSWPRPSQD EYSWQQQRLG FPERDPYASP
     SQDSYGQSGQ DSYGSQTQDT YAPSSQDYRP QPMERPSYDG QRSEYEQQRS DYDQSRQDYD
     QRDARRELPE QATGSGHVHR GGPVGPNLPA SGAPGPLAAQ PAPAPGPGEP TARLNPKYLF
     DTFVIGASNR FAHAAAVAVA EAPAKAYNPL FIYGESGLGK THLLHAIGHY ARSLYPGTRV
     RYVSSEEFTN EFINSIRDGK GDSFRKRYRE MDILLVDDIQ FLADKESTQE EFFHTFNTLH
     NANKQIVLSS DRPPKQLVTL EDRLRNRFEW GLITDVQPPE LETRIAILRK KAVQEQLNAP
     PEVLEFIASR ISRNIRELEG ALIRVTAFAS LNRQPVDLGL TEIVLKDLIP GGEDSAPEIT
     STAIMSATAD YFGLTVEDLC GTSRGRALVT ARQIAMYLCR ELTDLSLPKI GALFGGRDHT
     TVMHADRKIR NLMAERRSIY NQVTELTNRI KNG
//
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