ID S3AFK8_9STRE Unreviewed; 244 AA.
AC S3AFK8;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Segregation and condensation protein A {ECO:0000256|HAMAP-Rule:MF_01805};
GN Name=scpA {ECO:0000256|HAMAP-Rule:MF_01805};
GN ORFNames=HMPREF1481_01084 {ECO:0000313|EMBL:EPD87993.1};
OS Streptococcus sp. HPH0090.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1203590 {ECO:0000313|EMBL:EPD87993.1, ECO:0000313|Proteomes:UP000014396};
RN [1] {ECO:0000313|EMBL:EPD87993.1, ECO:0000313|Proteomes:UP000014396}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HPH0090 {ECO:0000313|EMBL:EPD87993.1,
RC ECO:0000313|Proteomes:UP000014396};
RG The Broad Institute Genomics Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Schmidt T.M., Dover J., Dai D.,
RA Walker B., Young S., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Allen A.W., Alvarado L., Arachchi H.M., Berlin A.M.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Streptococcus sp. HPH0090.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Participates in chromosomal partition during cell division.
CC May act via the formation of a condensin-like complex containing Smc
CC and ScpB that pull DNA away from mid-cell into both cell halves.
CC {ECO:0000256|HAMAP-Rule:MF_01805}.
CC -!- SUBUNIT: Component of a cohesin-like complex composed of ScpA, ScpB and
CC the Smc homodimer, in which ScpA and ScpB bind to the head domain of
CC Smc. The presence of the three proteins is required for the association
CC of the complex with DNA. {ECO:0000256|HAMAP-Rule:MF_01805}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01805}.
CC Note=Associated with two foci at the outer edges of the nucleoid region
CC in young cells, and at four foci within both cell halves in older
CC cells. {ECO:0000256|HAMAP-Rule:MF_01805}.
CC -!- SIMILARITY: Belongs to the ScpA family. {ECO:0000256|HAMAP-
CC Rule:MF_01805}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPD87993.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ATCD01000001; EPD87993.1; -; Genomic_DNA.
DR RefSeq; WP_016466838.1; NZ_KE150464.1.
DR AlphaFoldDB; S3AFK8; -.
DR STRING; 1203590.HMPREF1481_01084; -.
DR PATRIC; fig|1203590.3.peg.1055; -.
DR eggNOG; COG1354; Bacteria.
DR HOGENOM; CLU_038686_3_3_9; -.
DR Proteomes; UP000014396; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR Gene3D; 6.10.250.2410; -; 1.
DR Gene3D; 1.10.10.580; Structural maintenance of chromosome 1. Chain E; 1.
DR HAMAP; MF_01805; ScpA; 1.
DR InterPro; IPR003768; ScpA.
DR InterPro; IPR023093; ScpA-like_C.
DR PANTHER; PTHR33969; SEGREGATION AND CONDENSATION PROTEIN A; 1.
DR PANTHER; PTHR33969:SF2; SEGREGATION AND CONDENSATION PROTEIN A; 1.
DR Pfam; PF02616; SMC_ScpA; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|HAMAP-Rule:MF_01805};
KW Cell division {ECO:0000256|HAMAP-Rule:MF_01805};
KW Chromosome partition {ECO:0000256|ARBA:ARBA00022829, ECO:0000256|HAMAP-
KW Rule:MF_01805}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01805}.
SQ SEQUENCE 244 AA; 28569 MW; DBCA4F0CCEF76FF8 CRC64;
MDIKLKDFEG PLDLLLHLVS KYQMDIYDVP ITEVIEQYLA YISTLQAMRL EVAGEYMVMA
SQLMLIKSRK LLPKVAEVTD LEDDLEQDLL SQIEEYRKFK LLGEQLEVKH QERAQYYSKA
PTELIYEDAE LVHDKTTIDL FLAFSTLLTK KKEEFSKSHT TILRDEYKIE DMMVIVREAL
VEGQQLCLQD LFKETKDLQE VITLFLATLE LIKTQEILLI QKESFGDIYL MKKNEENQVE
QSQA
//
