ID S3BV97_OPHP1 Unreviewed; 851 AA.
AC S3BV97;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Exosome complex exonuclease rrp {ECO:0000313|EMBL:EPE03331.1};
GN ORFNames=F503_07634 {ECO:0000313|EMBL:EPE03331.1};
OS Ophiostoma piceae (strain UAMH 11346) (Sap stain fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Ophiostoma.
OX NCBI_TaxID=1262450 {ECO:0000313|EMBL:EPE03331.1, ECO:0000313|Proteomes:UP000016923};
RN [1] {ECO:0000313|EMBL:EPE03331.1, ECO:0000313|Proteomes:UP000016923}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 11346 {ECO:0000313|EMBL:EPE03331.1,
RC ECO:0000313|Proteomes:UP000016923};
RX PubMed=23725015; DOI=10.1186/1471-2164-14-373;
RA Haridas S., Wang Y., Lim L., Massoumi Alamouti S., Jackman S., Docking R.,
RA Robertson G., Birol I., Bohlmann J., Breuil C.;
RT "The genome and transcriptome of the pine saprophyte Ophiostoma piceae, and
RT a comparison with the bark beetle-associated pine pathogen Grosmannia
RT clavigera.";
RL BMC Genomics 14:373-373(2013).
CC -!- SIMILARITY: Belongs to the exosome component 10/RRP6 family.
CC {ECO:0000256|ARBA:ARBA00043957}.
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DR EMBL; KE148168; EPE03331.1; -; Genomic_DNA.
DR AlphaFoldDB; S3BV97; -.
DR STRING; 1262450.S3BV97; -.
DR VEuPathDB; FungiDB:F503_07634; -.
DR eggNOG; KOG2206; Eukaryota.
DR HOGENOM; CLU_010129_0_1_1; -.
DR OMA; TMDIIWL; -.
DR OrthoDB; 2880475at2759; -.
DR Proteomes; UP000016923; Unassembled WGS sequence.
DR GO; GO:0000176; C:nuclear exosome (RNase complex); IEA:InterPro.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:InterPro.
DR CDD; cd06147; Rrp6p_like_exo; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR012588; Exosome-assoc_fac_Rrp6_N.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR045092; Rrp6-like.
DR InterPro; IPR049559; Rrp6p-like_exo.
DR PANTHER; PTHR12124:SF47; EXOSOME COMPONENT 10; 1.
DR PANTHER; PTHR12124; POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF08066; PMC2NT; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00341; HRDC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000313|EMBL:EPE03331.1};
KW Exosome {ECO:0000256|ARBA:ARBA00022835};
KW Hydrolase {ECO:0000313|EMBL:EPE03331.1};
KW Nuclease {ECO:0000313|EMBL:EPE03331.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000016923};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT DOMAIN 452..533
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 114..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 662..851
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 662..676
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 681..742
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 745..769
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 829..851
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 851 AA; 94538 MW; 87144DFC4371346A CRC64;
MDSDDFKAQQ QKIQAALVAV NRTVNGIAAE DLTFLRTVNP DVASEIDVQA ARLLRLSNSL
IKSAANATGR KDVPTLEDAD DVELNWRGVV DVIDALLEKA DTTLDEYTGL LKRKDAPTTE
GGPDSKKAKP TERLDWSLRR ANIPKPQELF ERKPDNFDMG PWKPLLTKKP HATYVSLEDS
FTTFVDEYDH TQYKHPYETE ITRLQYPAHV YQKAEPIPFL PVDTTEAVWV DTFEGVEAML
EELRDANVIA VDLEHHDFRT YTGLLSLMQI STRTKDWVID TLQPWRHKLE ILNEVFADPT
KLKVFHGASS DIVWLQRDLG LYIVGLFDTY FACDCLEYGK RSLAFLLERF VNFDADKKYQ
MADWRIRPLS DEMLYYARSD THYLLYIFDM VRNELAEKSD RSNSEKDLTE YVLKKSKEVS
LSRHEAQFCD SETGQGTRGW LNNLVKTYTL LSGEQFAVYR ALYEWRDNIS RRLDESTGYI
MPNRVLSDVA RILPPDQKAL LSLLGNNTAR ATKASLGELF TLIQEAKERG ASGPTSIEFL
RSDKISALTK ASASHRHHNN FSASATASQL KVGGVATKDL TPLPDITDLR SNFSQLWGST
AISTGKSRGG EETGGALIEA PWYVQAAIAG PAPAVSADAT AAATPSAAKM RPNEDYEYIE
FPSSAQKTQP PASQLAPTDS EEAEEGAKKE PVVEEVAKEP EGAFTLKWGK KDVKEAKEGK
KMAKDDRKAA KLARKAAKQF KRAAESTSEA ASASEAASGG AQTSDSDGGA PINAGDDEEL
DDDYVPFNYD TAGSVLHAKK GQQNDQAQQK RKGKKVFNPY GGNPDAKGDD GPKPARRMHF
EKLGKGGTFK K
//
