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Database: UniProt
Entry: S3C765_OPHP1
LinkDB: S3C765_OPHP1
Original site: S3C765_OPHP1 
ID   S3C765_OPHP1            Unreviewed;      1257 AA.
AC   S3C765;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   13-SEP-2023, entry version 48.
DE   RecName: Full=Ras guanine-nucleotide exchange protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=F503_07165 {ECO:0000313|EMBL:EPE09389.1};
OS   Ophiostoma piceae (strain UAMH 11346) (Sap stain fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Ophiostoma.
OX   NCBI_TaxID=1262450 {ECO:0000313|EMBL:EPE09389.1, ECO:0000313|Proteomes:UP000016923};
RN   [1] {ECO:0000313|EMBL:EPE09389.1, ECO:0000313|Proteomes:UP000016923}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAMH 11346 {ECO:0000313|EMBL:EPE09389.1,
RC   ECO:0000313|Proteomes:UP000016923};
RX   PubMed=23725015; DOI=10.1186/1471-2164-14-373;
RA   Haridas S., Wang Y., Lim L., Massoumi Alamouti S., Jackman S., Docking R.,
RA   Robertson G., Birol I., Bohlmann J., Breuil C.;
RT   "The genome and transcriptome of the pine saprophyte Ophiostoma piceae, and
RT   a comparison with the bark beetle-associated pine pathogen Grosmannia
RT   clavigera.";
RL   BMC Genomics 14:373-373(2013).
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DR   EMBL; KE148147; EPE09389.1; -; Genomic_DNA.
DR   AlphaFoldDB; S3C765; -.
DR   STRING; 1262450.S3C765; -.
DR   VEuPathDB; FungiDB:F503_07165; -.
DR   eggNOG; KOG3417; Eukaryota.
DR   HOGENOM; CLU_002116_1_0_1; -.
DR   OMA; SATICHR; -.
DR   OrthoDB; 68574at2759; -.
DR   Proteomes; UP000016923; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF354; GUANINE-NUCLEOTIDE EXCHANGE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06570)-RELATED; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016923};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          58..121
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          801..921
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          981..1238
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          350..372
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          546..712
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          727..782
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1151..1171
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        548..573
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        580..622
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        680..712
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        727..776
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1153..1171
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1257 AA;  136759 MW;  ED61374D8DDB2AC6 CRC64;
     MAMLNSQPLR SSLSVAPLAL FKSHESAVGD DVYMSSTSST TGSAVTSSGT DSAPVFHNFL
     RAYYAFHPSY SPGDSTVTLP MREGDVILVH SIHTNGWADG TLLASGARGW LPTNYCDAYD
     PEEMRSLLNA LLNFWDLMRS TTVNDNEIFG NQEFMKGIIA GVRYLLERTQ CLTRESSPIQ
     RHDGLRRCRK SLLSELSSLV KSAKRLQDHQ HIVDPSESAN DIVDEMILKA FKIVTKAVRF
     FDVLEEDRRQ RAPAVAVMAT VVEVNSAPPT PPADTVTFNA EATPQEIDET HVSHESQMAP
     ITIVENVDAD NNDTITLSSS APTPGSLTVS SATPVNKRLS SIANNYHHRL SHSSTHASHR
     MSSSSISHRV SLAGPSPLSQ AQNLVSSRLG DRHDTFLSYL GSFIGRLHLQ SQSRPHLALA
     IKQSATSGGQ LLVVVDVVSA HNSLSQEILY KSRVAMCNRI VDLVCLARDI LTNQMADVED
     VIMPQDNGRL LTAATNCVKA TGECVAKTKW VIERIGDFEY QFDDSILAFD FDLDLSVLDA
     AAAENTASAP APSATSQLSL SAHSATDDEQ RPVTAGGSAS VVDSVVSSSV SDFPPPSLVA
     SVSATSSPSK RTTRSNLSID KPLPSVPVNL SSPIEEKPLS SSHRRSLSVS VAGRPSSFAA
     TEDMHAVPTM APPAPEPSQQ RSGLLPTLPR LSTTMPGDDQ TTVDGSTLHD GEFSASFHSE
     SLTALSSGTT STYASRNSES SLRSQTSTRA TTPEHGAAPK NQPSLSDLSM AASSTVADEN
     DDDLESKLLE RTYAHELMFN KEGQVTGGTL PALVERLTTH ESTPDAMFVS TFYLTFRLFC
     TPTKLTEALI ERFEYVGESP HMAGPVRLRV YNAFKGWLES HWREETDHEA LKLIVPFAES
     RLGLVLPSAG RRLLELTNRV SSSDGSLVPR LVSSMGKTST SISQYVPPDT PLPASVLSKS
     LQHSLANWKI GGTAPIIMDF DPLEMARQLT MRQMSIFCSI LPEELLGSQW MKKGGIGSPN
     VKAMTALSTD ISNLVADTIL QYSEVKKRAG VIKQWIKIAH QCYELHNYDA LMAIICSLNS
     STITRLRRTW DMISVKRRET LKMLQAIVEP SQNNKVLRGR LHDHVPPCLP FLGMYLTDLA
     FNDIGNPATK QLPGQDGCDQ NQNSSSGSGL TVVNFDKHTR TAKIIGELQR FQIPYRLTEV
     ADVQDWVTNQ ISRVRELEAP GNNVQVSYYR KSLLLEPRET QAAAKAVIDS GASAVSV
//
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