ID S3C765_OPHP1 Unreviewed; 1257 AA.
AC S3C765;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 13-SEP-2023, entry version 48.
DE RecName: Full=Ras guanine-nucleotide exchange protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=F503_07165 {ECO:0000313|EMBL:EPE09389.1};
OS Ophiostoma piceae (strain UAMH 11346) (Sap stain fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Ophiostoma.
OX NCBI_TaxID=1262450 {ECO:0000313|EMBL:EPE09389.1, ECO:0000313|Proteomes:UP000016923};
RN [1] {ECO:0000313|EMBL:EPE09389.1, ECO:0000313|Proteomes:UP000016923}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 11346 {ECO:0000313|EMBL:EPE09389.1,
RC ECO:0000313|Proteomes:UP000016923};
RX PubMed=23725015; DOI=10.1186/1471-2164-14-373;
RA Haridas S., Wang Y., Lim L., Massoumi Alamouti S., Jackman S., Docking R.,
RA Robertson G., Birol I., Bohlmann J., Breuil C.;
RT "The genome and transcriptome of the pine saprophyte Ophiostoma piceae, and
RT a comparison with the bark beetle-associated pine pathogen Grosmannia
RT clavigera.";
RL BMC Genomics 14:373-373(2013).
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DR EMBL; KE148147; EPE09389.1; -; Genomic_DNA.
DR AlphaFoldDB; S3C765; -.
DR STRING; 1262450.S3C765; -.
DR VEuPathDB; FungiDB:F503_07165; -.
DR eggNOG; KOG3417; Eukaryota.
DR HOGENOM; CLU_002116_1_0_1; -.
DR OMA; SATICHR; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000016923; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF354; GUANINE-NUCLEOTIDE EXCHANGE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06570)-RELATED; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000016923};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 58..121
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 801..921
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 981..1238
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 350..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 546..712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 727..782
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1151..1171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 548..573
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 580..622
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 680..712
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 727..776
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1153..1171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1257 AA; 136759 MW; ED61374D8DDB2AC6 CRC64;
MAMLNSQPLR SSLSVAPLAL FKSHESAVGD DVYMSSTSST TGSAVTSSGT DSAPVFHNFL
RAYYAFHPSY SPGDSTVTLP MREGDVILVH SIHTNGWADG TLLASGARGW LPTNYCDAYD
PEEMRSLLNA LLNFWDLMRS TTVNDNEIFG NQEFMKGIIA GVRYLLERTQ CLTRESSPIQ
RHDGLRRCRK SLLSELSSLV KSAKRLQDHQ HIVDPSESAN DIVDEMILKA FKIVTKAVRF
FDVLEEDRRQ RAPAVAVMAT VVEVNSAPPT PPADTVTFNA EATPQEIDET HVSHESQMAP
ITIVENVDAD NNDTITLSSS APTPGSLTVS SATPVNKRLS SIANNYHHRL SHSSTHASHR
MSSSSISHRV SLAGPSPLSQ AQNLVSSRLG DRHDTFLSYL GSFIGRLHLQ SQSRPHLALA
IKQSATSGGQ LLVVVDVVSA HNSLSQEILY KSRVAMCNRI VDLVCLARDI LTNQMADVED
VIMPQDNGRL LTAATNCVKA TGECVAKTKW VIERIGDFEY QFDDSILAFD FDLDLSVLDA
AAAENTASAP APSATSQLSL SAHSATDDEQ RPVTAGGSAS VVDSVVSSSV SDFPPPSLVA
SVSATSSPSK RTTRSNLSID KPLPSVPVNL SSPIEEKPLS SSHRRSLSVS VAGRPSSFAA
TEDMHAVPTM APPAPEPSQQ RSGLLPTLPR LSTTMPGDDQ TTVDGSTLHD GEFSASFHSE
SLTALSSGTT STYASRNSES SLRSQTSTRA TTPEHGAAPK NQPSLSDLSM AASSTVADEN
DDDLESKLLE RTYAHELMFN KEGQVTGGTL PALVERLTTH ESTPDAMFVS TFYLTFRLFC
TPTKLTEALI ERFEYVGESP HMAGPVRLRV YNAFKGWLES HWREETDHEA LKLIVPFAES
RLGLVLPSAG RRLLELTNRV SSSDGSLVPR LVSSMGKTST SISQYVPPDT PLPASVLSKS
LQHSLANWKI GGTAPIIMDF DPLEMARQLT MRQMSIFCSI LPEELLGSQW MKKGGIGSPN
VKAMTALSTD ISNLVADTIL QYSEVKKRAG VIKQWIKIAH QCYELHNYDA LMAIICSLNS
STITRLRRTW DMISVKRRET LKMLQAIVEP SQNNKVLRGR LHDHVPPCLP FLGMYLTDLA
FNDIGNPATK QLPGQDGCDQ NQNSSSGSGL TVVNFDKHTR TAKIIGELQR FQIPYRLTEV
ADVQDWVTNQ ISRVRELEAP GNNVQVSYYR KSLLLEPRET QAAAKAVIDS GASAVSV
//