ID S3CE07_GLAL2 Unreviewed; 624 AA.
AC S3CE07;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=histone deacetylase {ECO:0000256|ARBA:ARBA00012111};
DE EC=3.5.1.98 {ECO:0000256|ARBA:ARBA00012111};
GN ORFNames=GLAREA_08590 {ECO:0000313|EMBL:EPE24737.1};
OS Glarea lozoyensis (strain ATCC 20868 / MF5171).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Helotiaceae; Glarea.
OX NCBI_TaxID=1116229 {ECO:0000313|EMBL:EPE24737.1, ECO:0000313|Proteomes:UP000016922};
RN [1] {ECO:0000313|EMBL:EPE24737.1, ECO:0000313|Proteomes:UP000016922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20868 / MF5171 {ECO:0000313|Proteomes:UP000016922};
RX PubMed=23688303; DOI=10.1186/1471-2164-14-339;
RA Chen L., Yue Q., Zhang X., Xiang M., Wang C., Li S., Che Y.,
RA Ortiz-Lopez F.J., Bills G.F., Liu X., An Z.;
RT "Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in
RT the fungus Glarea lozoyensis.";
RL BMC Genomics 14:339-339(2013).
CC -!- SIMILARITY: Belongs to the histone deacetylase family. HD type 1
CC subfamily. {ECO:0000256|ARBA:ARBA00006457}.
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DR EMBL; KE145373; EPE24737.1; -; Genomic_DNA.
DR RefSeq; XP_008088825.1; XM_008090634.1.
DR AlphaFoldDB; S3CE07; -.
DR STRING; 1116229.S3CE07; -.
DR GeneID; 19467638; -.
DR KEGG; glz:GLAREA_08590; -.
DR eggNOG; KOG1342; Eukaryota.
DR HOGENOM; CLU_007727_0_0_1; -.
DR OMA; EHRWDKH; -.
DR OrthoDB; 1327607at2759; -.
DR Proteomes; UP000016922; Unassembled WGS sequence.
DR GO; GO:1902494; C:catalytic complex; IEA:UniProt.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0004407; F:histone deacetylase activity; IEA:UniProtKB-EC.
DR GO; GO:0010468; P:regulation of gene expression; IEA:UniProt.
DR CDD; cd10004; RPD3-like; 1.
DR Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR InterPro; IPR000286; His_deacetylse.
DR InterPro; IPR003084; His_deacetylse_1.
DR InterPro; IPR023801; His_deacetylse_dom.
DR InterPro; IPR037138; His_deacetylse_dom_sf.
DR InterPro; IPR023696; Ureohydrolase_dom_sf.
DR PANTHER; PTHR10625:SF13; HISTONE DEACETYLASE HDAC1; 1.
DR PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR Pfam; PF00850; Hist_deacetyl; 1.
DR PRINTS; PR01270; HDASUPER.
DR PRINTS; PR01271; HISDACETLASE.
DR SUPFAM; SSF52768; Arginase/deacetylase; 1.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Reference proteome {ECO:0000313|Proteomes:UP000016922}.
FT DOMAIN 38..326
FT /note="Histone deacetylase"
FT /evidence="ECO:0000259|Pfam:PF00850"
FT REGION 384..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 507..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 565..584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 596..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 415..435
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 624 AA; 68762 MW; FBA50E51DA387B8E CRC64;
MTSFAPIDPP APNGPSTKKR VAYFYDSDVG NYAYVAGHPM KPHRIRLAHS LIMNYGVYQK
MEIYRAKPAT RHEMTQFHTD EYIDFLQKVT PDNMDTFAKE QGKYNVGDDC PVFDGLFEFC
GISAGGSMEG AARLNRGKCD IAINWAGGLH HAKKSEASGF CYVNDIVLGI IELLRFKKRV
LYIDIDVHHG DGVEEAFYTT DRVMTVSFHK YGEYFPGTGE LRDIGVGSGK NYAVNFPLRD
GINDETYKSI FEPVIQSVMD YYDPEAIVLQ CGGDSLSGDR LGCFNLSMRG HANCVQFVKS
FNKPTLVLGG GGYTMRNVAR TWAFETGVLV GQDMGPMLPF NEYYEYYGPD YELDVRSSNM
ENANSKDYLE KIKIQVIENL KKTAHAPSVQ MTDIPRTTLT GGTEDDDHEL DDMDEDDNKD
TRHTKRRWDQ RITRDDELEE SEDEEEAHAN GVRPQEGQIK RRNIMDYQNA NAAASDVDMD
SGIASPVAAN DVDDLVTAQA TEANAEVIAD IMDEKGIEPG STETGEAGPS NSASRAPSPK
AVVVDQDGDT EMGGDATEIE TVAEAVPEAV IPSPSPKKSA TPEAIEVALK PVEVAEVKQE
SEAERSEKDV EGETAAETAK AAEL
//
