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Database: UniProt
Entry: S3CRT8_OPHP1
LinkDB: S3CRT8_OPHP1
Original site: S3CRT8_OPHP1 
ID   S3CRT8_OPHP1            Unreviewed;       524 AA.
AC   S3CRT8;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   24-JAN-2024, entry version 35.
DE   RecName: Full=Isocitrate lyase {ECO:0000256|PIRNR:PIRNR001362};
GN   ORFNames=F503_07119 {ECO:0000313|EMBL:EPE09343.1};
OS   Ophiostoma piceae (strain UAMH 11346) (Sap stain fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Ophiostoma.
OX   NCBI_TaxID=1262450 {ECO:0000313|EMBL:EPE09343.1, ECO:0000313|Proteomes:UP000016923};
RN   [1] {ECO:0000313|EMBL:EPE09343.1, ECO:0000313|Proteomes:UP000016923}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAMH 11346 {ECO:0000313|EMBL:EPE09343.1,
RC   ECO:0000313|Proteomes:UP000016923};
RX   PubMed=23725015; DOI=10.1186/1471-2164-14-373;
RA   Haridas S., Wang Y., Lim L., Massoumi Alamouti S., Jackman S., Docking R.,
RA   Robertson G., Birol I., Bohlmann J., Breuil C.;
RT   "The genome and transcriptome of the pine saprophyte Ophiostoma piceae, and
RT   a comparison with the bark beetle-associated pine pathogen Grosmannia
RT   clavigera.";
RL   BMC Genomics 14:373-373(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate +
CC         succinate; Xref=Rhea:RHEA:16809, ChEBI:CHEBI:15361,
CC         ChEBI:CHEBI:30031, ChEBI:CHEBI:57429; EC=4.1.3.30;
CC         Evidence={ECO:0000256|ARBA:ARBA00001050};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR001362-3};
CC       Note=Can also use Mn(2+) ion. {ECO:0000256|PIRSR:PIRSR001362-3};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC   -!- SIMILARITY: Belongs to the isocitrate lyase/PEP mutase superfamily.
CC       Isocitrate lyase family. {ECO:0000256|ARBA:ARBA00005704,
CC       ECO:0000256|PIRNR:PIRNR001362}.
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DR   EMBL; KE148147; EPE09343.1; -; Genomic_DNA.
DR   AlphaFoldDB; S3CRT8; -.
DR   STRING; 1262450.S3CRT8; -.
DR   VEuPathDB; FungiDB:F503_07119; -.
DR   eggNOG; KOG1260; Eukaryota.
DR   HOGENOM; CLU_019214_2_2_1; -.
DR   OMA; GMDHADY; -.
DR   OrthoDB; 1981645at2759; -.
DR   Proteomes; UP000016923; Unassembled WGS sequence.
DR   GO; GO:0004451; F:isocitrate lyase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0046421; F:methylisocitrate lyase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.10.850; -; 1.
DR   Gene3D; 3.20.20.60; Phosphoenolpyruvate-binding domains; 1.
DR   InterPro; IPR006254; Isocitrate_lyase.
DR   InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR   InterPro; IPR040442; Pyrv_Kinase-like_dom_sf.
DR   NCBIfam; TIGR01346; isocit_lyase; 1.
DR   PANTHER; PTHR21631:SF3; BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN; 1.
DR   PANTHER; PTHR21631; ISOCITRATE LYASE/MALATE SYNTHASE; 1.
DR   Pfam; PF00463; ICL; 1.
DR   PIRSF; PIRSF001362; Isocit_lyase; 2.
DR   SUPFAM; SSF51621; Phosphoenolpyruvate/pyruvate domain; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|PIRNR:PIRNR001362};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR001362-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR001362-3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016923}.
FT   BINDING         170
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001362-3"
SQ   SEQUENCE   524 AA;  58407 MW;  5564E0B808DC16E8 CRC64;
     MSICKLDVDA EEKAFQDQIA AVEKEWAQPW RAHIKRPYSA KAIAAMRNTI PLSYPSSLQG
     RKFWEQLEAH RVAGTCEKTY GTTEPTVMSQ MAKHQQTVYV SGALCGLSEV QHPGMDHADY
     PWDTVPKVVD KLFKAQLWHD QRQNQFRLRH TKAERANLEG YDFMMPIVAD ADMGFGGLTS
     TVKLARSFVE AGVAMIHLDD LAIGMKKFTI GEGRTVVPTS EYVSRLTAVR MQFDIMGVDT
     LLMCRCDTDR SQFITSTIDP RDHAYIIGST VADIEPLVDA VRAGMAAGRI YQDARDEWKA
     RAGLMTFDDA VKAQAASPDD YDKYVASGAT EYGKSLREKR KAATAALGKD VVFDWELSRS
     KEGSYMWKPT VQAIVERALT VAPLGDMTWA RMDAPVWNDI VEFHEGVRKV YPERLFAFGF
     TGMFDYIKNG FTQEQVESFS SDMAKLGIVW QVQPIYSVSG LNLTVDKFSG AWQKDGIAGY
     IENISKPSRV PPVVDGFHKA SYAGSFLADA FFATVAGEDT STKQ
//
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