ID S3D702_GLAL2 Unreviewed; 421 AA.
AC S3D702;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Heme-dependent catalase-like protein {ECO:0000313|EMBL:EPE32919.1};
GN ORFNames=GLAREA_05931 {ECO:0000313|EMBL:EPE32919.1};
OS Glarea lozoyensis (strain ATCC 20868 / MF5171).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Helotiaceae; Glarea.
OX NCBI_TaxID=1116229 {ECO:0000313|EMBL:EPE32919.1, ECO:0000313|Proteomes:UP000016922};
RN [1] {ECO:0000313|EMBL:EPE32919.1, ECO:0000313|Proteomes:UP000016922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20868 / MF5171 {ECO:0000313|Proteomes:UP000016922};
RX PubMed=23688303; DOI=10.1186/1471-2164-14-339;
RA Chen L., Yue Q., Zhang X., Xiang M., Wang C., Li S., Che Y.,
RA Ortiz-Lopez F.J., Bills G.F., Liu X., An Z.;
RT "Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in
RT the fungus Glarea lozoyensis.";
RL BMC Genomics 14:339-339(2013).
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971,
CC ECO:0000256|PIRSR:PIRSR038928-2};
CC -!- PATHWAY: Alkaloid biosynthesis. {ECO:0000256|ARBA:ARBA00004913}.
CC -!- SIMILARITY: Belongs to the catalase family.
CC {ECO:0000256|ARBA:ARBA00005329}.
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DR EMBL; KE145358; EPE32919.1; -; Genomic_DNA.
DR RefSeq; XP_008079536.1; XM_008081345.1.
DR AlphaFoldDB; S3D702; -.
DR STRING; 1116229.S3D702; -.
DR GeneID; 19464985; -.
DR KEGG; glz:GLAREA_05931; -.
DR eggNOG; KOG0047; Eukaryota.
DR HOGENOM; CLU_010645_2_0_1; -.
DR OMA; GSFKYVH; -.
DR OrthoDB; 3198922at2759; -.
DR Proteomes; UP000016922; Unassembled WGS sequence.
DR GO; GO:0004096; F:catalase activity; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009820; P:alkaloid metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR Gene3D; 2.40.180.10; Catalase core domain; 1.
DR InterPro; IPR018028; Catalase.
DR InterPro; IPR024711; Catalase_clade1/3.
DR InterPro; IPR011614; Catalase_core.
DR InterPro; IPR002226; Catalase_haem_BS.
DR InterPro; IPR020835; Catalase_sf.
DR PANTHER; PTHR11465; CATALASE; 1.
DR PANTHER; PTHR11465:SF9; CATALASE; 1.
DR Pfam; PF00199; Catalase; 1.
DR PIRSF; PIRSF038928; Catalase_clade1-3; 2.
DR PRINTS; PR00067; CATALASE.
DR SMART; SM01060; Catalase; 1.
DR SUPFAM; SSF56634; Heme-dependent catalase-like; 1.
DR PROSITE; PS00437; CATALASE_1; 1.
DR PROSITE; PS51402; CATALASE_3; 1.
PE 3: Inferred from homology;
KW Alkaloid metabolism {ECO:0000256|ARBA:ARBA00022589};
KW Heme {ECO:0000256|PIRSR:PIRSR038928-2};
KW Iron {ECO:0000256|PIRSR:PIRSR038928-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR038928-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000016922}.
FT DOMAIN 2..355
FT /note="Catalase core"
FT /evidence="ECO:0000259|SMART:SM01060"
FT BINDING 295
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000256|PIRSR:PIRSR038928-2"
SQ SEQUENCE 421 AA; 48437 MW; 8E26952C164C3DFF CRC64;
MIDIKSMQIL TNLIDQITHD ISDICDIDML LGVGKKTDCV MRLSTTAFER GSAETIRDVK
GMAVKFFTEQ GNWDWVCLNI PMFFLRDPAK FPAMMRAQRR DPETNLVNPN NWWEWLCENH
EALHMMMFQY SDFGTMFNWR SMSGYVGHAY KWVKSDGSWK YVHFFFASDQ GPNFEQGNKE
KDLAEEDPDY ATRDLHGAIE RGEFPSWTAK VQVVDPEDAH KLSFNILDIT KHWNLGNYPR
DVPVIPGRPF GKLTLKRNPK DFFTEIEQLA FAPSHLVPGV EPSEDPILQA RLFAYPDAQR
YRLGENNEQL PANRCKGNIE QPATRPVSVG TPNAEWLAKV SSKEWTQPNE LDYKYPREFW
KILPVLRNDA FQEALVVNMS KSVAETRPDV RAKVYSTLAS IAADLSERVK AMTEKLVAER
V
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