ID   S3D748_GLAL2            Unreviewed;      1235 AA.
AC   S3D748;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=PX {ECO:0000313|EMBL:EPE27821.1};
GN   ORFNames=GLAREA_04612 {ECO:0000313|EMBL:EPE27821.1};
OS   Glarea lozoyensis (strain ATCC 20868 / MF5171).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Helotiales; Helotiaceae; Glarea.
OX   NCBI_TaxID=1116229 {ECO:0000313|EMBL:EPE27821.1, ECO:0000313|Proteomes:UP000016922};
RN   [1] {ECO:0000313|EMBL:EPE27821.1, ECO:0000313|Proteomes:UP000016922}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 20868 / MF5171 {ECO:0000313|Proteomes:UP000016922};
RX   PubMed=23688303; DOI=10.1186/1471-2164-14-339;
RA   Chen L., Yue Q., Zhang X., Xiang M., Wang C., Li S., Che Y.,
RA   Ortiz-Lopez F.J., Bills G.F., Liu X., An Z.;
RT   "Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in
RT   the fungus Glarea lozoyensis.";
RL   BMC Genomics 14:339-339(2013).
CC   -!- SIMILARITY: Belongs to the sorting nexin family.
CC       {ECO:0000256|ARBA:ARBA00010883}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KE145369; EPE27821.1; -; Genomic_DNA.
DR   RefSeq; XP_008085180.1; XM_008086989.1.
DR   AlphaFoldDB; S3D748; -.
DR   STRING; 1116229.S3D748; -.
DR   GeneID; 19463667; -.
DR   KEGG; glz:GLAREA_04612; -.
DR   eggNOG; ENOG502RM76; Eukaryota.
DR   HOGENOM; CLU_007315_0_0_1; -.
DR   OMA; INGWIIH; -.
DR   OrthoDB; 2727031at2759; -.
DR   Proteomes; UP000016922; Unassembled WGS sequence.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR   CDD; cd06093; PX_domain; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   InterPro; IPR003114; Phox_assoc.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR013937; Sorting_nexin_C.
DR   PANTHER; PTHR22775:SF47; MEIOTICALLY UP-REGULATED GENE 122 PROTEIN; 1.
DR   PANTHER; PTHR22775; SORTING NEXIN; 1.
DR   Pfam; PF08628; Nexin_C; 1.
DR   Pfam; PF00787; PX; 1.
DR   Pfam; PF02194; PXA; 1.
DR   SMART; SM00313; PXA; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   PROSITE; PS51207; PXA; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016922}.
FT   DOMAIN          314..495
FT                   /note="PXA"
FT                   /evidence="ECO:0000259|PROSITE:PS51207"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          289..308
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          606..680
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          917..1072
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          539..573
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..17
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        291..305
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        610..672
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        948..962
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        963..1004
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1015..1063
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1235 AA;  134159 MW;  FAEDFEFBC1157112 CRC64;
     MSRNPRNESE DHLRAAGAAG RCAHTGGPGP VDPANVEHSS TRAPEGLLLQ LPSLFQMLRI
     DFQSRSNLIC RRRAEVGGPS IGVQTDTKPQ LFASDGTPAP SHPRTWNPRT FLSGHPLSQT
     VLVRIASELR SYSTLISSTL RQTIVINPLP VRLHPQHAPT AHLDAMNGIR SKLEDEDALQ
     ETPQHSPVKA LSPPDAPLPH DGDYVTKALQ FLSTATPETL GAIAVGLAAA TYLILGKLGL
     ILIGALGGVI LHATWEGQST LIGVGVGAKD RRQEGLDVVA RLFAWRDAQP KDEDEDEDEG
     DETEHLADSF EAFRPETKAA LTEFVEAVIR DYVKWWYDPI LPKETSFPAA SRQTLTKFML
     SVSNHLSRKR PADSFLDFLT NSSSIVIVFL NELSSALSTQ PASVPAAEAV YTYLSANPDS
     NLANVLNEKQ HMKKFRMIAD DILQNFLEKP AYACDPARLF LREILAGVVL DMTLKSCSKP
     EWINGWIVHL LEDGEPDFSQ AIDVGMGNVP DVSTLSDIDG NVGNIGLAKS PATPSIQEFK
     KHQKRLSKAE EAMEEAMEEA KRLSQLMAEE DANKQAIRKP VDNVPKALVA GVETSTNELA
     VETKGLPAIP SPRTPNQTSE GFQNISTTHN SVCESPRSTT SPNEVWEASS PSASPERQES
     TPFTSFDQIV PPSTPVALQD VSPMPRRKTV SLTLHNANII IHDDSTTMDK GPLRSKPNSE
     YLIQIEPASS DHPGWMIVRR YPDFETLHEV LRRIAKLSGV VAFSEQHSTL PNWKEHTKAS
     LRGELERYIR DACWDRHLAE SEGMKRFLEK DSQNTTAPTA KIGFGWPAPS AIETMGKGML
     DVLASAPRGV ADGGKALGGG ISGVFNNLGK EIGNLGQKKT NGSTANVGAH VAGRASTSTL
     PRVDSSGSMA TSIYSNRRAR ASEDSLRAVP LVATQPSKVP PMERRPSYHS IAEVENERES
     RPSTSARSSM SGSRSANHSR APSRAPSRRG TPLNSPTQAT MEQLRLPPPP SAISEDYGTD
     TTINTDSTAP SRNSMSTAPS QPSPGRPSIS TPRISSANIS ASPIKQRKEP MPMTEEETCV
     AVELLFAVVS ELYTLSSAWK FRRTLLNAAK TFLLRPGNPS LSSIQSLIQD SVIASNTSDA
     GIAAHLRKLR QNSLPTEEEL KAWPAEMTAE EKESLRLKAR KLLVQRGVPV ALSGVMGQAA
     TSEAMGRVFD CLQIEEVNRG LMFGMLLQCV RAVTQ
//