ID   S3D767_OPHP1            Unreviewed;       808 AA.
AC   S3D767;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   08-NOV-2023, entry version 37.
DE   SubName: Full=Dna mismatch repair protein {ECO:0000313|EMBL:EPE09225.1};
GN   ORFNames=F503_07001 {ECO:0000313|EMBL:EPE09225.1};
OS   Ophiostoma piceae (strain UAMH 11346) (Sap stain fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Ophiostoma.
OX   NCBI_TaxID=1262450 {ECO:0000313|EMBL:EPE09225.1, ECO:0000313|Proteomes:UP000016923};
RN   [1] {ECO:0000313|EMBL:EPE09225.1, ECO:0000313|Proteomes:UP000016923}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAMH 11346 {ECO:0000313|EMBL:EPE09225.1,
RC   ECO:0000313|Proteomes:UP000016923};
RX   PubMed=23725015; DOI=10.1186/1471-2164-14-373;
RA   Haridas S., Wang Y., Lim L., Massoumi Alamouti S., Jackman S., Docking R.,
RA   Robertson G., Birol I., Bohlmann J., Breuil C.;
RT   "The genome and transcriptome of the pine saprophyte Ophiostoma piceae, and
RT   a comparison with the bark beetle-associated pine pathogen Grosmannia
RT   clavigera.";
RL   BMC Genomics 14:373-373(2013).
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000256|ARBA:ARBA00006082}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KE148147; EPE09225.1; -; Genomic_DNA.
DR   AlphaFoldDB; S3D767; -.
DR   STRING; 1262450.S3D767; -.
DR   VEuPathDB; FungiDB:F503_07001; -.
DR   eggNOG; KOG1978; Eukaryota.
DR   HOGENOM; CLU_374299_0_0_1; -.
DR   OrthoDB; 1369806at2759; -.
DR   Proteomes; UP000016923; Unassembled WGS sequence.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0061982; P:meiosis I cell cycle process; IEA:UniProt.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms-like.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR   PANTHER; PTHR10073:SF41; MISMATCH REPAIR PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05820)-RELATED; 1.
DR   Pfam; PF13589; HATPase_c_3; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016923}.
FT   DOMAIN          242..419
FT                   /note="DNA mismatch repair protein S5"
FT                   /evidence="ECO:0000259|SMART:SM01340"
FT   REGION          83..103
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          428..628
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        440..470
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        568..600
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   808 AA;  86749 MW;  D9BECB5404D7B278 CRC64;
     MPHPATTAEM SIKALPTDTR RLIESTSLIA SPVCLVRELA DNAIDARASC VDIFISRNTV
     DKVEVRDNGS GIASVDFGAL GRQSHSSKTE ASGTGASGPP SLGFRGQGLA SANNLGYVTV
     TTRTHNDAVA STFRLVPNIG GVASDSQKVA SARVGTTVNV TCVFSALPVR RKVAVQESSK
     AIAGIKTLLR SYALARPNLR LSLKILQPLG VASPTEAKLT APWDYRPTTV GIGSHASMRQ
     AVSALFGAEV ARQCQEIVAS SKELVAGQST IAQTLSQTVP ERMNSDEIDN NGELNDFVFE
     AWLPQPGADL AKLKLGSFVS VDGRPISADR YGSTGKKLTT IFTTAFGKSL TALQQYEGYG
     SPPQPLPQSK LHGLFIRLNI KCPLGSYDAN VDSSKTDVLF ADERFLCDAF ERLCKRVYSA
     TESLRHSQPF GRGSLFPRTP DRTHTATTFS LPASSLNGPS QNTQAARSAL RGPSRQPGSG
     IIDGTPTPAS RLHEQGSDPC DAPVRIQIPS RGGGNRRRLV SAPRTKAVRS LRTPPASPVA
     RSRGRTNRMQ NHHSPESPDL PGLVSCDGLR QTTISFHGPP NNNNDNDKQR QGTRQHPNQV
     NEANRLEEEE PAVFGTAPET GGTNTESTLP SFVSARELCT TEPQVCAGPS RVQPRSQFGS
     PLEQGIVRPH GRLSHAAQPE TYGGQSTRSL NVLTSTIRRP SQIMKVDIQQ LRRSAVQFAR
     NIRTWEKAGE EGAEGSERGD DRLSPEMADI ASIEARLRAA VTAWAAKTMS GTSNTSSIDM
     GEGPVQVELY LRKSLKQKAL MVRSAREE
//