ID S3DCA5_GLAL2 Unreviewed; 1077 AA.
AC S3DCA5;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=alpha-mannosidase {ECO:0000256|ARBA:ARBA00012752};
DE EC=3.2.1.24 {ECO:0000256|ARBA:ARBA00012752};
GN ORFNames=GLAREA_05400 {ECO:0000313|EMBL:EPE36062.1};
OS Glarea lozoyensis (strain ATCC 20868 / MF5171).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Helotiaceae; Glarea.
OX NCBI_TaxID=1116229 {ECO:0000313|EMBL:EPE36062.1, ECO:0000313|Proteomes:UP000016922};
RN [1] {ECO:0000313|EMBL:EPE36062.1, ECO:0000313|Proteomes:UP000016922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20868 / MF5171 {ECO:0000313|Proteomes:UP000016922};
RX PubMed=23688303; DOI=10.1186/1471-2164-14-339;
RA Chen L., Yue Q., Zhang X., Xiang M., Wang C., Li S., Che Y.,
RA Ortiz-Lopez F.J., Bills G.F., Liu X., An Z.;
RT "Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in
RT the fungus Glarea lozoyensis.";
RL BMC Genomics 14:339-339(2013).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792}.
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DR EMBL; KE145353; EPE36062.1; -; Genomic_DNA.
DR RefSeq; XP_008076880.1; XM_008078689.1.
DR AlphaFoldDB; S3DCA5; -.
DR STRING; 1116229.S3DCA5; -.
DR GeneID; 19464454; -.
DR KEGG; glz:GLAREA_05400; -.
DR eggNOG; KOG4342; Eukaryota.
DR HOGENOM; CLU_003442_0_1_1; -.
DR OMA; GQYWDAW; -.
DR OrthoDB; 2786490at2759; -.
DR Proteomes; UP000016922; Unassembled WGS sequence.
DR GO; GO:0004559; F:alpha-mannosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR CDD; cd10812; GH38N_AMII_ScAms1_like; 1.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR041147; GH38_C.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF17677; Glyco_hydro38C2; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000016922}.
FT DOMAIN 556..634
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
SQ SEQUENCE 1077 AA; 122280 MW; 84ED6BAD40B415C5 CRC64;
MGGETFEIAK LKSSYPKLSA HPVGQWIPNI YKDRIGMFTG GGQYETKNLR AMLTEGSASG
EPHVKLSVWD APDLTRPTFK EATSHKFEST SVGSWFGPSW STHWFKVQLT VPKELCKKEL
LELRWDANNE GMVWTEDGNP LQGLTGGGER TEWILPKKFR DGKEHTIYIE MACNGMFGNA
PGGDSIQPPD PNKYFQLSKA EIVAVNVEAR HLYIDMWEIG DAAREFPADS WEQHKALKIA
NDIIDAFELG NQDSILKGRK IAQEYLGKNS SSSKVYDSGT EPIVYGVGHC HIDTCWLWPW
AETKRKVARS WSNQCDLMDR YPEHRFTCSQ AQQYKWLKQY YPYVFDRVKE KVKKGTFQPV
GGSWVEHDTN MPSGESLVRQ FVYGQRLFES NFGERCRTFW LPDTFGYSSQ LPQLCRLAGM
TRFFTQKLSW NNINKFPHTT FNWVSLDGSQ VICHMAPSET YTAEANFGDV RRSVTQHKSM
DQDNTSLLVF GKGDGGGGPT WEHLEKLRRC RGMADTVGLL PRVHLGEGVE EFFDRLEKKA
SEGLDFVTWY GELYFELHRG TYTTQANNKR NNRKSEIMLH DIEQLATLAS IKSGYKYPKE
DIDDMWEAVL LCQFHDCLPG SSIEMCYDDS DELYAKVFKT GEKIFKDLQS VLGVQDVSPT
SGDNLLALNT MPWHRREIIS IGENRAGVAC GEGNLLNIKT FKITETPEVT VEEVRKGVFV
LQNDQLRVSV EDGYISSLYD RKAEREVVAK GGKANQLVIF DDKPLYWQAW DVEVYHLDSR
KELSPGTTKI FQADAHQVSV VTETKISDKS WIKTYISLSA AFKGQQSYVE MHSEVEWQES
MKFLKVEFPV DVRNTEASYE TQYGVVRRPT HYNTTWDMAK FEVCCHKFAD LSEHGYGVSI
LNDSKYGFAT CGNLMRLSLL RAPKAPDAHA DMGRHHIRWA ILPHTGDLGP TTVRTAYNFN
NPLKLAQSTT PITPATFSNP IKLIGNPSLI LDTIKRGEDD EDVSRGELPK RKGKSVVLRI
YDSLGGTSKG TIETTLNVKK VYKTNILEDD EDEISISDGK IDITLRPFEV ATFRLQL
//
