ID S3DSX3_GLAL2 Unreviewed; 722 AA.
AC S3DSX3;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Sorting nexin MVP1 {ECO:0000256|ARBA:ARBA00014268};
GN ORFNames=GLAREA_00698 {ECO:0000313|EMBL:EPE29538.1};
OS Glarea lozoyensis (strain ATCC 20868 / MF5171).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Helotiaceae; Glarea.
OX NCBI_TaxID=1116229 {ECO:0000313|EMBL:EPE29538.1, ECO:0000313|Proteomes:UP000016922};
RN [1] {ECO:0000313|EMBL:EPE29538.1, ECO:0000313|Proteomes:UP000016922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20868 / MF5171 {ECO:0000313|Proteomes:UP000016922};
RX PubMed=23688303; DOI=10.1186/1471-2164-14-339;
RA Chen L., Yue Q., Zhang X., Xiang M., Wang C., Li S., Che Y.,
RA Ortiz-Lopez F.J., Bills G.F., Liu X., An Z.;
RT "Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in
RT the fungus Glarea lozoyensis.";
RL BMC Genomics 14:339-339(2013).
CC -!- FUNCTION: Required for vacuolar protein sorting.
CC {ECO:0000256|ARBA:ARBA00002474}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR EMBL; KE145367; EPE29538.1; -; Genomic_DNA.
DR RefSeq; XP_008083647.1; XM_008085456.1.
DR AlphaFoldDB; S3DSX3; -.
DR STRING; 1116229.S3DSX3; -.
DR GeneID; 19459756; -.
DR KEGG; glz:GLAREA_00698; -.
DR eggNOG; KOG2273; Eukaryota.
DR HOGENOM; CLU_009058_1_0_1; -.
DR OMA; SSPWDMP; -.
DR OrthoDB; 45524at2759; -.
DR Proteomes; UP000016922; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro.
DR CDD; cd07597; BAR_SNX8; 1.
DR CDD; cd06866; PX_SNX8_Mvp1p_like; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR028662; SNX8/Mvp1.
DR InterPro; IPR035704; SNX8/Mvp1_PX.
DR InterPro; IPR045734; Snx8_BAR_dom.
DR PANTHER; PTHR47554; SORTING NEXIN MVP1; 1.
DR PANTHER; PTHR47554:SF1; SORTING NEXIN MVP1; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF19566; Snx8_BAR_dom; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000016922};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 343..457
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 178..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..200
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 722 AA; 78917 MW; 8D01DA2451824022 CRC64;
MSLFGSSPEE PAPIRSSTTK PRNTLFDDND SPAPASKSTL FAEDDAPWGM PTPKKPARGD
LVKSLLDGAD IPDSYVDIFD SLLKDDALSS GGKISADGIT HTVRAGNLDA ASQDRIVNLV
TSGGQTSNLN RNEFNVLLAL IGLAQENEDI TLDGVDERRR NLPVPKTPSL STAAAFPNAS
ELAAKPPQSV SSSASETLRS QKPKTPRKPS MDFPEADPWA SPALHRGHSH EQGLPKANGG
TSAVESNGAH GPTRTTSNFT TASQSSPNGA SHLSSQAAPT TPAAGGGWAY DGAESSATPF
GTETDPSIGG DGFGISGGDG DRPIQNIPTR SFGGGRVSGV GVEETILVTL LPEKEGMFMF
QHHNYQVASP RRGSKVVRRY SDFVWLLDCL HKRYPFRQLP LLPPKRVGVN GNHLAADSTF
IEKRRRGLGR FANALVRHPV LSQEQLVIMF LTVPTELAVW RKQATISVQE EFAGKSLPPG
LEDSLSPTLH ELFETSRTGI RRSADIYINL CNLVDRLAKR NEGLAADTNR LALSLQSLTD
VSQDTYATDT NDVPLLNGGL QSMAKHLSNS QSLLEDEARA WDLGVLEDLK RQRDSLVSMR
EMFDRRDRYD KDNIPYLEKR IQNNENKLVA IRAKPENLMK PGEIEKVTEA IIKDKQSIVA
QHARGVFVKE CIRDELMNFQ SSQYHVSRLS QDWAQERVKY SELQADNWKQ LQEEAEAMPL
GE
//
