ID S3E502_GLAL2 Unreviewed; 380 AA.
AC S3E502;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=NAD(P)-binding Rossmann-fold containing protein {ECO:0000313|EMBL:EPE33493.1};
GN ORFNames=GLAREA_06506 {ECO:0000313|EMBL:EPE33493.1};
OS Glarea lozoyensis (strain ATCC 20868 / MF5171).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Helotiaceae; Glarea.
OX NCBI_TaxID=1116229 {ECO:0000313|EMBL:EPE33493.1, ECO:0000313|Proteomes:UP000016922};
RN [1] {ECO:0000313|EMBL:EPE33493.1, ECO:0000313|Proteomes:UP000016922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20868 / MF5171 {ECO:0000313|Proteomes:UP000016922};
RX PubMed=23688303; DOI=10.1186/1471-2164-14-339;
RA Chen L., Yue Q., Zhang X., Xiang M., Wang C., Li S., Che Y.,
RA Ortiz-Lopez F.J., Bills G.F., Liu X., An Z.;
RT "Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in
RT the fungus Glarea lozoyensis.";
RL BMC Genomics 14:339-339(2013).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004406}.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219}.
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DR EMBL; KE145358; EPE33493.1; -; Genomic_DNA.
DR RefSeq; XP_008080110.1; XM_008081919.1.
DR AlphaFoldDB; S3E502; -.
DR STRING; 1116229.S3E502; -.
DR GeneID; 19465559; -.
DR KEGG; glz:GLAREA_06506; -.
DR eggNOG; KOG1430; Eukaryota.
DR HOGENOM; CLU_007383_6_8_1; -.
DR OMA; KMFAVAR; -.
DR OrthoDB; 1133at2759; -.
DR Proteomes; UP000016922; Unassembled WGS sequence.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000016922}.
FT DOMAIN 16..290
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 380 AA; 41902 MW; E69C0F206F3E7E0D CRC64;
MANSIATEII PLSPVLITGG CGFIGSHLVE EILASEPTCQ IHVIDINTTP NRLNDPRVTY
HTGDISRLED VEAAMSAARP CTIFHVACPD SMVTLDVSVF QRVNINGAQN LLDAAEKIGS
VKAFINTSTS SVIHDNISDL INADENLPVL QYPVQKRVYT LTKAEAEALI LAANRKRGDS
SMLTVSMRPA TAFGERDTIC MGKIVSSCRQ GKGKFQIGPG KNQYDFIYIK NLVDAHLLAA
YALLRAHGKA APPKGMRIDG ETFNVTNDER ILFWEFNRLI SASVGFSIKN EDVRVVPKWV
ALLMAFISEY STWIRSWGSE QALVTREAVR LTTIERTMNG EKAKRLLGYK PKVSIREGIE
KGGKWFMDEA AKALETKKTV
//
