ID S3IVU4_MICAE Unreviewed; 390 AA.
AC S3IVU4;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Methyltransferase {ECO:0000256|RuleBase:RU362026};
DE EC=2.1.1.- {ECO:0000256|RuleBase:RU362026};
GN ORFNames=MAESPC_05058 {ECO:0000313|EMBL:EPF17080.1};
OS Microcystis aeruginosa SPC777.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Chroococcales; Microcystaceae; Microcystis.
OX NCBI_TaxID=482300 {ECO:0000313|EMBL:EPF17080.1, ECO:0000313|Proteomes:UP000014617};
RN [1] {ECO:0000313|EMBL:EPF17080.1, ECO:0000313|Proteomes:UP000014617}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SPC 777 {ECO:0000313|Proteomes:UP000014617};
RX PubMed=23908289;
RA Fiore M.F., Alvarenga D.O., Varani A.M., Hoff-Risseti C., Crespim E.,
RA Ramos R.T., Silva A., Schaker P.D., Heck K., Rigonato J., Schneider M.P.;
RT "Draft Genome Sequence of the Brazilian Toxic Bloom-Forming Cyanobacterium
RT Microcystis aeruginosa Strain SPC777.";
RL Genome Announc. 1:e00547-13(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-
CC methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:16857, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:13674,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:85452, ChEBI:CHEBI:137933; EC=2.1.1.113;
CC Evidence={ECO:0000256|ARBA:ARBA00001893};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family. N(4)
CC subfamily. {ECO:0000256|ARBA:ARBA00010203}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPF17080.1}.
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DR EMBL; ASZQ01000276; EPF17080.1; -; Genomic_DNA.
DR RefSeq; WP_016517222.1; NZ_ASZQ01000276.1.
DR AlphaFoldDB; S3IVU4; -.
DR REBASE; 69096; M.Mae777ORF5058P.
DR PATRIC; fig|482300.6.peg.5619; -.
DR OrthoDB; 9800801at2; -.
DR Proteomes; UP000014617; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0015667; F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002941; DNA_methylase_N4/N6.
DR InterPro; IPR017985; MeTrfase_CN4_CS.
DR InterPro; IPR001091; RM_Methyltransferase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR Pfam; PF01555; N6_N4_Mtase; 1.
DR PRINTS; PR00508; S21N4MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00093; N4_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:EPF17080.1};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EPF17080.1}.
FT DOMAIN 134..365
FT /note="DNA methylase N-4/N-6"
FT /evidence="ECO:0000259|Pfam:PF01555"
SQ SEQUENCE 390 AA; 45098 MW; 85A291F222B2EFF4 CRC64;
MEKELVSDKR GYLLRTVAEA KEIVLNWLRE INLVNAIKLG LPEVDDRYHI WRVPLCNDQK
KTVGEVVIDA YTTEILADRT TRTEIIIARL LKQDESKLET RKKTKKEYKL SSLINTIGFG
DCSELLEEMP AESVDLIFTS PPYFNARPEY SEFEEYESYL LKLRQVIRKC HRVLSEGRFF
VINISPVLLR RASRNQASKR IAVPFDLHRI FIEEGYDFID DIIWLKPEGA GWATGRGRRF
AADRNPLQYK TVPVTEYVLV YRKHTDLLID WHIRNHPDQE VVKASKIADG YERTNVWKIN
PVTNSKHPAA FPVELAEKVI TYYSFKGDVV LDPFAGSGTV GLAAASLDRR FVLFESNFNY
IELIRKLITE GNPTDLDSII WLNCPLENQQ
//
