ID S3L278_TREMA Unreviewed; 370 AA.
AC S3L278;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=HMPREF9194_01209 {ECO:0000313|EMBL:EPF30884.1};
OS Treponema maltophilum ATCC 51939.
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC Treponema.
OX NCBI_TaxID=1125699 {ECO:0000313|EMBL:EPF30884.1, ECO:0000313|Proteomes:UP000014541};
RN [1] {ECO:0000313|EMBL:EPF30884.1, ECO:0000313|Proteomes:UP000014541}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51939 {ECO:0000313|EMBL:EPF30884.1,
RC ECO:0000313|Proteomes:UP000014541};
RG The Broad Institute Genomics Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Leonetti C., Blanton J.M.,
RA Dewhirst F.E., Izard J., Walker B., Young S., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Treponema maltophilum ATCC 51939.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPF30884.1}.
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DR EMBL; ATFF01000006; EPF30884.1; -; Genomic_DNA.
DR RefSeq; WP_016525495.1; NZ_KE332518.1.
DR AlphaFoldDB; S3L278; -.
DR STRING; 1125699.HMPREF9194_01209; -.
DR REBASE; 415758; M.Tma51939ORF1209P.
DR PATRIC; fig|1125699.3.peg.1230; -.
DR eggNOG; COG3392; Bacteria.
DR HOGENOM; CLU_034356_0_0_12; -.
DR OrthoDB; 9805629at2; -.
DR Proteomes; UP000014541; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:InterPro.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR012327; MeTrfase_D12.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR Pfam; PF02086; MethyltransfD12; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000014541}.
SQ SEQUENCE 370 AA; 42108 MW; F0FC33F0238FE4E4 CRC64;
MQNENAEYLS DQLITYLGNK RRLLNFIGEA VDSVKKKLNK EKLRIFDVFS GSGIVSRYLK
QSASYLAAND LELYSYLINT CYLSNSSERD MVQLRGFFCD LKEKLDECEF TGEWKRGVIS
ELYAPEDDSN IKKGERVFYT KRNAAYIDTA RSFIDSYPER LRVFFIAPLL AAASVHANTG
GVFKGFYKNR ETGIGEFGGK NRDALSRITG DIDLEFPVFS TYDCQVDIYR RDANELVLST
AEVDLAYLDP PYNQHPYGSN YFMLNVIAEN KRPHNPSSVS GIPSDWNRSA YNTAKGAQKA
LGELIENVRA KYVLLSFNSE GFTTKDELTC MMGSMGKLNV FESPYNAFRA SRNLKNRNAH
VTEYLFLLEK
//
