ID S3TIC6_9GAMM Unreviewed; 730 AA.
AC S3TIC6;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Protein-tyrosine kinase {ECO:0000313|EMBL:EPG35420.1};
GN ORFNames=F907_03300 {ECO:0000313|EMBL:EPG35420.1};
OS Acinetobacter colistiniresistens.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Acinetobacter.
OX NCBI_TaxID=280145 {ECO:0000313|EMBL:EPG35420.1, ECO:0000313|Proteomes:UP000014559};
RN [1] {ECO:0000313|EMBL:EPG35420.1, ECO:0000313|Proteomes:UP000014559}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIPH 2036 {ECO:0000313|EMBL:EPG35420.1,
RC ECO:0000313|Proteomes:UP000014559};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Cerqueira G., Feldgarden M., Courvalin P., Perichon B.,
RA Grillot-Courvalin C., Clermont D., Rocha E., Yoon E.-J., Nemec A.,
RA Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A., Gujja S.,
RA Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Acinetobacter sp. NIPH 2036.";
RL Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001074};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the etk/wzc family.
CC {ECO:0000256|ARBA:ARBA00008883}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPG35420.1}.
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DR EMBL; ATGK01000018; EPG35420.1; -; Genomic_DNA.
DR RefSeq; WP_016653328.1; NZ_UEGJ01000025.1.
DR AlphaFoldDB; S3TIC6; -.
DR GeneID; 45416472; -.
DR PATRIC; fig|1217696.3.peg.3243; -.
DR HOGENOM; CLU_009912_0_0_6; -.
DR Proteomes; UP000014559; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05387; BY-kinase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR032807; GNVR.
DR InterPro; IPR003856; LPS_length_determ_N_term.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005702; Wzc-like_C.
DR NCBIfam; TIGR01007; eps_fam; 1.
DR PANTHER; PTHR32309; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR32309:SF13; TYROSINE-PROTEIN KINASE ETK-RELATED; 1.
DR Pfam; PF13614; AAA_31; 1.
DR Pfam; PF13807; GNVR; 1.
DR Pfam; PF02706; Wzz; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EPG35420.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137,
KW ECO:0000313|EMBL:EPG35420.1}.
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 440..460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 10..106
FT /note="Polysaccharide chain length determinant N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02706"
FT DOMAIN 382..463
FT /note="Tyrosine kinase G-rich"
FT /evidence="ECO:0000259|Pfam:PF13807"
FT DOMAIN 548..696
FT /note="AAA"
FT /evidence="ECO:0000259|Pfam:PF13614"
FT COILED 270..376
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 730 AA; 82133 MW; B6FEE5EA38D937C6 CRC64;
MNQNSKISED TIDLKELFFS LIAQWKIIAL CVILSLICAI LYLRITSDIY SVDAMVQVEE
SKGAASAALL GDLSKVTGGL AQKSPADAEI EILRSRMVLG QVIRNLNLDI TIKDNTSGLM
NKLASKNDDK LKYQHDAVTF TNQQNTLIIK QLAVPERYLD KPLKLEFKES NHFNFTYKDQ
IVFNGKLNQK GTSETNKGSW VVEINAQGDL SKQSYTLTKF ALPTAVKNFN EIYSVAEKGK
MTGVIGLSYL GQDPEQITQI LNNVLNVYHQ QNIERKSLEA KQTLVFLEKQ LPELRKQLED
SEIKFNQFRE KYKTVDVNAE SELLLKQNID LEKLKIELQQ KQAELSAKYT NDHPLIRQID
AQVTELNKKI ADLNNRLTQL PETQRLYLQL YRDVKVNTEL YTSLLNSYQQ LKIANAGEIG
NVRIIDTAVE PVKPIKPQKL IVLILSIFVG GFIGVLIALI RNMFQTGVKD SAQIENEFDL
PVYATVPRSP IQETRMSILK KKKSIPILAV KHSDDIAIES LRSIRTAIHF ALSSAKNNII
MISGPAPEVG KSFVSTNLAT IFAQSNKRVL LIDADMRRGY MHKYFNLEVT PGLSELLSQQ
VNLEQVLHQT HVENLDVISR GKSPTNPSEM LSSSFFKELL EKLSPLYDHI IIDTPPVLAV
TDGIIISQYV GVNLMIARFA KSQMKELELS VNRFEQAGVK VNGFILNDIQ RSSASGGYNY
AYAYAAQKDN
//
