ID S3XC03_9ACTN Unreviewed; 1044 AA.
AC S3XC03;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Peptidase S8/S53 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=HMPREF1531_00464 {ECO:0000313|EMBL:EPH06862.1};
OS Propionibacterium sp. oral taxon 192 str. F0372.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Propionibacteriaceae; Propionibacterium.
OX NCBI_TaxID=1203605 {ECO:0000313|EMBL:EPH06862.1, ECO:0000313|Proteomes:UP000014567};
RN [1] {ECO:0000313|EMBL:EPH06862.1, ECO:0000313|Proteomes:UP000014567}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0372 {ECO:0000313|EMBL:EPH06862.1,
RC ECO:0000313|Proteomes:UP000014567};
RG The Broad Institute Genomics Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Kirega A., Socransky S.S.,
RA Dewhirst F.E., Izard J., Walker B., Young S., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Propionibacterium sp. oral taxon 192 str. F0372.";
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC ECO:0000256|RuleBase:RU003355}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPH06862.1}.
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DR EMBL; ATFL01000002; EPH06862.1; -; Genomic_DNA.
DR AlphaFoldDB; S3XC03; -.
DR STRING; 1203605.HMPREF1531_00464; -.
DR PATRIC; fig|1203605.3.peg.474; -.
DR eggNOG; COG1404; Bacteria.
DR HOGENOM; CLU_005356_0_0_11; -.
DR OrthoDB; 614750at2; -.
DR Proteomes; UP000014567; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd07474; Peptidases_S8_subtilisin_Vpr-like; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 2.
DR InterPro; IPR010435; Fn3_5.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR034213; S8_Vpr-like.
DR PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR Pfam; PF06280; fn3_5; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000014567};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1044
FT /note="Peptidase S8/S53 domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5039002864"
FT DOMAIN 180..628
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT DOMAIN 439..525
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 709..777
FT /note="Fn3-like"
FT /evidence="ECO:0000259|Pfam:PF06280"
FT REGION 76..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 189
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 261
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 592
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 1044 AA; 107262 MW; D58B35914E38B9CB CRC64;
MRMRRWLVIA GLVSITAPTS MAVADDPVGN ASDLSIASAS SGPLDSGQDA GIDQLKQLDE
RVTVMVELPK APVAAAEAKN GGDLDQSGEK SVRDDIASEQ DRIVPAIEAL GGSIEFRMQS
AYNGMRVSID SNRLSDLEKL EGIKQVHAIT QHDRSSVVSV PYIGAPVAWQ GNGFAGGYTG
ENVKVAIVDS GIDYTHATFG GPGTVAAFDE ATAVNDQSKM AGTRVKGGYD FAGDAYNGDN
TPVPDENPID CAADQGGPAG HGTHVANIAA GSGVRADGST YTGPYDENTH TDNEFAVGPG
VAPEADIYAV RVFGCSGTTN LVTEAMDWAV AHDMDVVNLS LGSSFGRVDS PDAVAVSNAV
AAGVVVVAAS GNSGAEPYLT GSPGTGAGVV SVAANDSAAT YPSADLKVGA STIEAINING
AELPAKGKVK VLREGDQIAN GCYAPQWDSA KVRGQIVVVR RDAKCASIQR VVHGQKYGAA
AVIMVNSADE LPPFIGEISR DTGTGDPFKV TIPFLGVKSS AAEALLGADD KKISLTKNQV
ANPGYTDLAA FTSAGPRSGD SAVRPTVTAP GVRISSAVAG SGNKAQAFSG TSMATPHASG
AAALARQAHP DWTSQEIAAA MVSTSDTDRV ANHSPSLGGG LINPIDVVYT SVFAYSDSTT
VDGTQITDAG ISFGYAEFVG SWTGDRVITL VNKGDQPVTL HGVIEPSRKS LPASVTLGSP
EVTVPAGGTA KVPVTMTVQA SDVPSSMVDP KEQNFHEVSG IVRLTTDAGQ ELTLPYLLAP
RVISKVSADQ TFKTATQSEV TLANKGGGIE ATSVLFTLGL QDPADIPDDG SDVGQDISSV
GVTSFKKGEQ TYLDFAVNSS SRFSNPASII FSITIDKDLD GVNDYLVYSE DAGVARGVRP
VGYPEIFIQD LKTNKAIAAG FLPLAPSDSS SIILEIKASD VGVNGKFAYG AKAASTGDRV
ATDVVNGTAY YDPTNKAFAD GQLFRLAPDA RQTVELAVNE TVAKDLGVLG YMVLALDNAQ
GATEAVTGPL TDPKQAAAVT SAAP
//
