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Database: UniProt
Entry: S3Y621_9MICO
LinkDB: S3Y621_9MICO
Original site: S3Y621_9MICO 
ID   S3Y621_9MICO            Unreviewed;       585 AA.
AC   S3Y621;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   RecName: Full=Pyruvate dehydrogenase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=HMPREF1484_00528 {ECO:0000313|EMBL:EPH17836.1};
OS   Dermabacter sp. HFH0086.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Dermabacteraceae;
OC   Dermabacter.
OX   NCBI_TaxID=1203568 {ECO:0000313|EMBL:EPH17836.1, ECO:0000313|Proteomes:UP000014577};
RN   [1] {ECO:0000313|EMBL:EPH17836.1, ECO:0000313|Proteomes:UP000014577}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HFH0086 {ECO:0000313|EMBL:EPH17836.1,
RC   ECO:0000313|Proteomes:UP000014577};
RG   The Broad Institute Genomics Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Schmidt T.M., Dai D., Dover J.,
RA   Walker B., Young S., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA   Abouelleil A., Allen A.W., Alvarado L., Arachchi H.M., Berlin A.M.,
RA   Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA   Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA   Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA   Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Dermabacter sp. HFH0086.";
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EPH17836.1}.
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DR   EMBL; ATFO01000002; EPH17836.1; -; Genomic_DNA.
DR   RefSeq; WP_016663461.1; NZ_KE340308.1.
DR   AlphaFoldDB; S3Y621; -.
DR   STRING; 1203568.HMPREF1484_00528; -.
DR   PATRIC; fig|1203568.3.peg.519; -.
DR   eggNOG; COG0028; Bacteria.
DR   HOGENOM; CLU_013748_3_0_11; -.
DR   Proteomes; UP000014577; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   CDD; cd02014; TPP_POX; 1.
DR   CDD; cd07039; TPP_PYR_POX; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR047211; POXB-like.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR000399; TPP-bd_CS.
DR   InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR   InterPro; IPR047212; TPP_POXB-like.
DR   InterPro; IPR047210; TPP_PYR_POXB-like.
DR   PANTHER; PTHR42981; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR   PANTHER; PTHR42981:SF2; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR   PROSITE; PS00187; TPP_ENZYMES; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000014577};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT   DOMAIN          5..115
FT                   /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02776"
FT   DOMAIN          191..321
FT                   /note="Thiamine pyrophosphate enzyme central"
FT                   /evidence="ECO:0000259|Pfam:PF00205"
FT   DOMAIN          384..530
FT                   /note="Thiamine pyrophosphate enzyme TPP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02775"
SQ   SEQUENCE   585 AA;  62713 MW;  21329BBF327889C6 CRC64;
     MAKKTLAQHT VDQLVAMGVE RIYGVVGDSL NPIVDAVRTT KGIEWIHVRN EEAAAFAAGA
     EARVTGKLGV CAGSCGPGNT HLVQGLYDNH RDSVPVLAIA SHIPSEKIGT GFFQETHPEL
     LFNECSAFCE MVNSGNHGAQ MLHNAAQTAL AKKDVSVLVI PGDIASQEVT IEATRTLTTT
     FGAIQPQASV VEELARLANS AKKITLFAGA GIEGARAEVL ELADTLKAPI GHAFGGKEFI
     QYNNPFDVGM SGLLGYGAAY EATHECDLLI LLGTDFPYSE FLPREGKPKV VQIDADGSRL
     GRRVPLDLGV HGDVALTIRA LLPQLKQKKN RSFLNSMLRK QEKELTHVVN SYTKRASRLK
     PIHPEYVASL LDEFADDDAV FTVDTGMCNV WAARYIEPNG KRRIFGSFRH GTMANALPQA
     IGASAAQPNR QVISMSGDGG LGMLMGELLT VRLHQLNTKI VVFNNSSLGM VKLEMLVAGL
     PDFETDHDSV NFAKIAEGAG IPSIRIENPK TLRKDLKKAL AAPGPMLIDI VTDPDALAMP
     PKITLEQMSG FATAGGKIVL EGGVGKMVNL AKSNVRNIPR PGAFF
//
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