ID S3ZTW0_9ACTN Unreviewed; 1274 AA.
AC S3ZTW0;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Putative Dimodular nonribosomal peptide synthase {ECO:0000313|EMBL:EPH46598.1};
GN ORFNames=STRAU_0337 {ECO:0000313|EMBL:EPH46598.1};
OS Streptomyces aurantiacus JA 4570.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces aurantiacus group.
OX NCBI_TaxID=1286094 {ECO:0000313|EMBL:EPH46598.1, ECO:0000313|Proteomes:UP000014629};
RN [1] {ECO:0000313|EMBL:EPH46598.1, ECO:0000313|Proteomes:UP000014629}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JA 4570 {ECO:0000313|EMBL:EPH46598.1,
RC ECO:0000313|Proteomes:UP000014629};
RA Gruening B.A., Praeg A., Erxleben A., Guenther S., Mueller M.;
RT "Draft Genome Sequence of Streptomyces aurantiacus, Which Produces
RT Setomimycin.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPH46598.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AOPZ01000014; EPH46598.1; -; Genomic_DNA.
DR RefSeq; WP_016638471.1; NZ_AOPZ01000014.1.
DR AlphaFoldDB; S3ZTW0; -.
DR PATRIC; fig|1286094.4.peg.327; -.
DR OrthoDB; 2472181at2; -.
DR Proteomes; UP000014629; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd19540; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000014629}.
FT DOMAIN 954..1029
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1274 AA; 139185 MW; 8CF37FFFC83AC566 CRC64;
MIPLSFAQRR YWFLHQLEGG ETWNMSAAFR LSGSLDQDAL AAAIRDVVER HEILRTTYVA
DEDGEPHQRI LPVAEAFEQA RMPVAEVAPQ DVDGAVDEAV AHGFDLAAEI PFRASLLRCS
PQEHVLVMVI HHIATDGSSG APLARDLATA YTARCEGRAP VWEPLPVQYK DFTLWQREVL
GDVDDPGSLA AAQLEYWRKE LAGIPQPLTL PLDRPRTDEV NTEGDAVAFT VKPQVAAGLE
KLSAERGTSM SMILQAALAV LLSKLGSGDD IPIATPIAGR TDEAMADLIG CFVNNLVLRV
DLSGAPSFTE LLARVREKSL AAYENQDLPF DLLVESINPD RSIAHKPLFQ VMSGWQNYER
PTLELSGLKV EFRQALNAKT MVDMYFSMGL DESGTVHGDI QYATDLFDRD TVEAIAERFE
SVLEQVVADP DRSVGDVDVL RAGERERLLA KVNDTAEPTL EAGLVEAVRR QAEATPEAIA
LIGVEETLTY QELEARSNRL AHWLIDRGVR PESLVAVCLP RTVNLMVTLL AVLKAGGAYV
PVDPDHPQSR IDYVLKQADP VLVLDAEALA GADCTPYPQS APQVAVRPEN TQYVIYTSGS
TGAPKGVAIP RGAVANFIAS VQRRFPLAPG ERMLFSTTVS FDMANTELWL PFVCGATMVM
ARKGTVTDPK AVVELIRRHD VTVVQATPAF WQMVLTREPE AAKGLRIITG AEAVPQRLAE
ALADQAAEVG NWYGPTETTT WSTMAPVKAG AAVAIGTPIG NTQVYVLDSR LCPVAPGVQG
EVYIAGDGMA RGYQGRPDMT AERFVACPFG PAGARMYRTG DVVRWNKSGQ LEYVARTDFQ
VKIRGFRIEL GEIEHVLAGH PAVAQAVVVV REDQPDDKRI VGYVVPETDA AAADGDGSTG
PLLAELAEYL RGRLPEYMVP SALIPLAQIP LTPNGKLDQR ALPAEHTDTT VSEGPRDPHE
EKLCAMFSEL LGKEKVGIHD DFFALGGHSL MATRLSLRIR NEFNVDMPLR TIIKYPTVAE
LASLALIGGI PVDSHDPFAV VLPLNTDPGT GKEPLWFFHG GGGLGWAYFS FVTHVQDRPA
YALQSRGSDG ADKLAGSVEE MVEDYITEML KIQPEGPFHL VGWSYGGTLV QAVAESLDRR
GHQVALTAIL DSMPGGHGFT EFHAGKTLAD YRSELEEFFG QYIGTDNQQD FLDRMSKVLA
NNTNHIMDFQ SPVYRGDVLF FSATNKDELY AHLWRPHVLG DIEVHDVYAM HHDMNMPAPV
AEVMEVINRK LAAQ
//
