ID S4R8I2_PETMA Unreviewed; 297 AA.
AC S4R8I2;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Opioid receptor mu1a {ECO:0000313|EMBL:ALF99984.1};
DE SubName: Full=Opioid receptor, mu 1 {ECO:0000313|Ensembl:ENSPMAP00000001513.1};
GN Name=OPRM1 {ECO:0000313|Ensembl:ENSPMAP00000001513.1};
GN Synonyms=OPRMa {ECO:0000313|EMBL:ALF99984.1};
OS Petromyzon marinus (Sea lamprey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000001513.1, ECO:0000313|Proteomes:UP000245300};
RN [1] {ECO:0000313|EMBL:ALF99984.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26337547; DOI=10.1093/molbev/msv179;
RA Yun S., Furlong M., Sim M., Cho M., Park S., Cho E.B., Reyes-Alcaraz A.,
RA Hwang J.I., Kim J., Seong J.Y.;
RT "Prevertebrate Local Gene Duplication Facilitated Expansion of the
RT Neuropeptide GPCR Superfamily.";
RL Mol. Biol. Evol. 32:2803-2817(2015).
RN [2] {ECO:0000313|Ensembl:ENSPMAP00000001513.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; KT261537; ALF99984.1; -; mRNA.
DR STRING; 7757.ENSPMAP00000001513; -.
DR Ensembl; ENSPMAT00000001520.1; ENSPMAP00000001513.1; ENSPMAG00000001376.1.
DR GeneTree; ENSGT00940000158236; -.
DR HOGENOM; CLU_009579_8_1_1; -.
DR Proteomes; UP000245300; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004985; F:G protein-coupled opioid receptor activity; IEA:InterPro.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001418; Opioid_rcpt.
DR PANTHER; PTHR24229:SF108; G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24229; NEUROPEPTIDES RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00384; OPIOIDR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000245300};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 18..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 62..81
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 102..121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 141..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 189..207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 227..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..247
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 297 AA; 34110 MW; B2775BA2D74DEA6B CRC64;
LWLSLVCRYT KMKTATNIYI FNLALADTLA TSTLPFQIVN YFMSTWPFGR VLCKLIISID
YYNMFTSIFT LTMMSIDRYI AVCHPVRALD FRTPVKAKLV NICIWSLSSA IGLPVMIIAV
TKQDKNGNVD CTLEFPIYWD NMLKTCVFVF AFFIPVCVIT VCYGLMITRL RSVRVLSGSK
EKDRTMRRIT RMVLVVVAAF VVCWTPIHLY VIVRAIVRIP ESAVVTVSWH VCIALGYVNS
SMNPFLYAFL DENFKRCFRE FCFRRNFRLD LPSTSRVRSI AREASSMNNL DGSNDNS
//
