ID   S4R977_PETMA            Unreviewed;      1456 AA.
AC   S4R977;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   27-MAR-2024, entry version 65.
DE   SubName: Full=Trio Rho guanine nucleotide exchange factor a {ECO:0000313|Ensembl:ENSPMAP00000001758.1};
OS   Petromyzon marinus (Sea lamprey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC   Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX   NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000001758.1, ECO:0000313|Proteomes:UP000245300};
RN   [1] {ECO:0000313|Ensembl:ENSPMAP00000001758.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   Ensembl; ENSPMAT00000001767.1; ENSPMAP00000001758.1; ENSPMAG00000001585.1.
DR   GeneTree; ENSGT00940000154766; -.
DR   Proteomes; UP000245300; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd13240; PH1_Kalirin_Trio_like; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   CDD; cd00170; SEC14; 1.
DR   CDD; cd00176; SPEC; 3.
DR   Gene3D; 1.20.58.60; -; 5.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR047054; Kalirin_TRIO_PH_1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR018159; Spectrin/alpha-actinin.
DR   InterPro; IPR002017; Spectrin_repeat.
DR   PANTHER; PTHR22826:SF210; CRAL-TRIO DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF00435; Spectrin; 3.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00150; SPEC; 5.
DR   SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF46966; Spectrin repeat; 6.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245300}.
FT   DOMAIN          1160..1335
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          1347..1456
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          381..407
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          748..775
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1456 AA;  167468 MW;  1117C701B65EE519 CRC64;
     SSEESAKKGF TVVIDMRGSK WDSIKPLLKT LQESFPASIH VALIIKPDNF WQKQKTNFGS
     SKFEFETSLV SIEGLCRLVD PSQLTAELDG SFPYEHEEWL SLRLALEEFV TAASHLLSRL
     EELQELLSRR DFPLDLEGAR RLIEEHAQLK RRVLRAPIEE LDREGQALLQ RIQVSGEAGG
     NADFQSLVPR ISGLLDKLHS TRQHLHQMWH GRKLKLDQCF QLRLFEQDAE KMFEWISHNK
     ALFLEGYTEI GPSHQQAVEL QAQHAHFARN SMNVYVNISR IMSVGSRLTE AGHYAAQQIK
     QIASHLDQEW KCFAAALDER STLLSMSALF HLKAEQYLSS VDAWYKACGD GDLPTELPDL
     EDAIHHHQGL YEQIATAYAE AGPPRCPPEH GREGASGQTA EAPEPRRRLA DGHGQLLESR
     AHRKVRLHQR LQLCVFQQDV QQVLDWIENH GEAFLSKHTG IGKSLHRARA LQKRHEDFEE
     VAQNTYTNAD KLLEAAEQLA QTGECDPEEI FQAAHALEDR IQDFVRRVEQ RKLLLDMSVS
     FHTHTKELWS WLEELQKELL DDVYAESVVA VQELISRFQQ QQQTMLQATV NVIKEGEDLI
     QQLRKTKQEC MVSGNSSIAH VEGVLHQLDE AQAQMEEIFQ ERKIKLDLFL QLRMFERDAV
     EVLSDLEAWN DELVRQLSEF DSDDLTLAEQ RLQRHADKSL TMNNLVFDVI RQGQELYQFV
     TDVQATGAGI EVTCDKDVDM GTRVQELLEF LHDKQQELEL NAEQHRKRLE QCLQLRHLQT
     NCSDSVCVCV TGRGARLYVL GWIRNGESML SASLINACSL SEAEQLQREH EQFQVQQKAE
     SLLGSVHYAP DTIRECAERV AAHWQQLMLK MEDRLKLVNA SVAFYKTSEQ VCSVLESLEQ
     EYKREEDWCG GGDKLGPGSD SDHVTPMINK HLEQKEAFLK ACTLARRNAE VFLKYIHRNN
     VSMPGMTSHT RGAEQQVKTI LSELLQRENR VLHFWTMRKR RLDQCQQYVV FERSAKQVSR
     LNHLSVVPVQ ESKFVKCREN PNRNKNISAG LETSRFNDTV CHQTKERVKL LIQLADSFVE
     KGHAHAGDIK KWVSLVDKQY RDFASGMAKY RAALEKALGV PSDKERELQL DTIPASLAEQ
     VKLREVSNHT DEERRKSARR KEFIMAELLQ TEKAYVRDLH ECLEIYLWEM TSGVEEIPPG
     IINKEDTIFG NMQEIFDFHN NIFLKELEKY EQLPEDVGHC FVTWADKFQM YVSYCKNKPD
     STQLIMDHAG TFFDEIQQRH GLANTISSYL IKPVQRITKY QLLLKELLTC CDERTGELKE
     ALEVMLSVPK RANDAMHLSM LEGFDENLDA QGELILQESF QVWDPKTLIR KGRERHLFLF
     ELALVFSKEV RDSSGNSKYL YKHKLLTSEL GVSDHVEGDA CKFTLWVGRT PTSDNKLVLK
     ASSIDTKQDW IKHIRE
//