ID   S4RAZ2_PETMA            Unreviewed;      1139 AA.
AC   S4RAZ2;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   27-MAR-2024, entry version 57.
DE   SubName: Full=Activating signal cointegrator 1 complex subunit 3 {ECO:0000313|Ensembl:ENSPMAP00000002373.1};
GN   Name=ASCC3 {ECO:0000313|Ensembl:ENSPMAP00000002373.1};
OS   Petromyzon marinus (Sea lamprey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC   Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX   NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000002373.1, ECO:0000313|Proteomes:UP000245300};
RN   [1] {ECO:0000313|Ensembl:ENSPMAP00000002373.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; S4RAZ2; -.
DR   STRING; 7757.ENSPMAP00000002373; -.
DR   Ensembl; ENSPMAT00000002385.1; ENSPMAP00000002373.1; ENSPMAG00000002163.1.
DR   GeneTree; ENSGT00940000155377; -.
DR   HOGENOM; CLU_000335_2_2_1; -.
DR   OMA; ETEMEHI; -.
DR   Proteomes; UP000245300; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0034641; P:cellular nitrogen compound metabolic process; IEA:UniProt.
DR   GO; GO:0010467; P:gene expression; IEA:UniProt.
DR   CDD; cd18022; DEXHc_ASCC3_2; 1.
DR   CDD; cd18795; SF2_C_Ski2; 2.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR   Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR004179; Sec63-dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR   PANTHER; PTHR47961:SF13; SEC63 DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 2.
DR   Pfam; PF02889; Sec63; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 2.
DR   SMART; SM00973; Sec63; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR   SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 2.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245300}.
FT   DOMAIN          71..265
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   DOMAIN          703..883
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          916..1123
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
SQ   SEQUENCE   1139 AA;  128886 MW;  B95CE561759BE950 CRC64;
     QVESTQSMIR IVGLSATLPN YLDVARFLHV NPYIGLFFFD SRFRPVPLSQ TFIGVKTTNK
     MQQMHDMDEV CYDKVLEQVK AGHQVMVFVH ARNATVRTAM ALREMAKNNG EAGFFTPPQS
     AEYGTAFKQV ERSRNKPMRE LFPDGFSTHH AGMLRPDRSL VEGLFSRGLV RVLVCTATLA
     WGVNLPAHAV IIKGTQIYDA KRGTFVDLGA LDVMQIFGRA GRPQYDTFGL GIIITSHDKL
     GRYLTLLTQQ NPIESQFQAS LQDNLNAEDE AGLATAAFEA VRWLSYTYLY VRMRANPLAY
     GINHSHYQAD PSLHKFREQM VVDAGRKLDK ARMIRFDERT GYFSPTDTGR TASHFYIKYN
     TIETFNDYFG PHLTESDVLS MVCKAEEFEQ IKVREDELGE LEQLADGYCL LPVAGGVENG
     YGKVNILLQT YISRGDVDCF SLVSDLSYIA QNAARIVRSL FETALRKRWP TMTSRLLALS
     KAIDRRLWGW AHPLRQFSAL PHTTLEKLEA RKMTVDKLRD MSSHDIGHMI HHVAMGQKIK
     QCVQQIPTLA LEASIQPITR TVLRVRLSIT ADFTWCDQVH GSVGEPWWIW VEDPTNDHIY
     HSENFMILKK QVLSQEAQCV TFTIPIFEPL PSQYYVRAVS DRWLGSEAVC AINFQQLILP
     ERHPPHTELL DLQPLPVSAL GDARLEALYR FTHFNPVQTQ IFHTLYHGDG NVLLGAPTGS
     GKTVAAELAI FRIFNAHPGA KAVYIAPLKA LVRERMEDWK VRLEPEAGKE CAAARVVELT
     GDVTPDARAI ASADLIVTTP EKWDGVSRSW HSRSYVKQVA LLVIDEIHLL GDDRGPVLEV
     IVSRTNFISS HTEKPVRVVG LSTALANARD LADWLAIKQV ILFNFRPSVR PVPLEAHIHG
     FPGQHYCPRM ATMNKPTFQA IRTHSPAKPV LIFVSSRRQT RLTALDLIAF LAGEDNPKQW
     LHTDETEMEH IISTVKDSNL KLCLAFGIGM HHAGLHERDR RTVEELFVNT RIQVLIATST
     LAWGVNFPAH LVIIKGTEYF DGKTRRYVDF PITDVLQMMG RAGRPQFDDQ GKAVIFVHDL
     KKDFYKKFLY EPFPVESSLL EVLADHLNAE ITSGTITSKQ DAMDYITWTY FFRRLIMNP
//