ID S4RDR0_PETMA Unreviewed; 582 AA.
AC S4RDR0;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=VWFA domain-containing protein {ECO:0000259|PROSITE:PS50234};
OS Petromyzon marinus (Sea lamprey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000003342.1, ECO:0000313|Proteomes:UP000245300};
RN [1] {ECO:0000313|Ensembl:ENSPMAP00000003342.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003762}; Single-
CC pass type I membrane protein {ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; S4RDR0; -.
DR Ensembl; ENSPMAT00000003357.1; ENSPMAP00000003342.1; ENSPMAG00000003066.1.
DR GeneTree; ENSGT00940000155465; -.
DR HOGENOM; CLU_004111_3_2_1; -.
DR Proteomes; UP000245300; Unplaced.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 2.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF26; INTEGRIN ALPHA-10; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 4.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000245300};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT REPEAT 5..63
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 149..333
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 400..453
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 455..517
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 524..581
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 582 AA; 63196 MW; 1A22A918B4D4CC00 CRC64;
FNLDTKRPTV FRGPEEAQFG FSVQQHYASG KNWLLVGAPW KGSAGTRPGD VYRCPLGLGS
EVTNSSCEKL GLEKVVSVPS VTEVKENMNL GMNLAPGPDP GSFTVCAPLW AQECGSSYFA
PGICSNVDSG FNVSESYAPT LQKCGSYMDI VFVLDGSNSI YPWSDVQNFL VKTLQSFHIG
PDQTQDDVCL PGANVVVVFK CTSQWRSLDH LGHCSHVHVL SDTPLYERWG VSLPSRSEAF
SPERGARPDA QKVMIVVTDG ESHDKYLLPE VIDQCERDGI TRYAIAVLRS YSSNADDVAR
LINEVRSIAS HPVERHFFNV TSEATLIDIV GTLGERIFSL EGTREKNETS FDLELSQAGF
SAHYVGGALM LGAVGAYEWM GTIVRRVGDE VSLPGKHAFE SALPSELRSH AAYLGYSLTS
ARTENGSTIL VAGAPRFNHT GRTVVFTQDH NSKVSVLKTL SGEQIGSYFG GEVCAMDVDG
DSVSDVLLVA APMFMDSSSR ETGRVYLYTF SPQRVRSQGV LEWSAHLSPA ESQDSRFGSA
LAAVPDLNQD GWGELAVGAP LEDERQGAVY LFQGHGRSLR TT
//
