ID S4RGI8_PETMA Unreviewed; 770 AA.
AC S4RGI8;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Unc-13 homolog Ba (C. elegans) {ECO:0008006|Google:ProtNLM};
OS Petromyzon marinus (Sea lamprey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000004320.1, ECO:0000313|Proteomes:UP000245300};
RN [1] {ECO:0000313|Ensembl:ENSPMAP00000004320.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; S4RGI8; -.
DR STRING; 7757.ENSPMAP00000004320; -.
DR Ensembl; ENSPMAT00000004337.1; ENSPMAP00000004320.1; ENSPMAG00000003926.1.
DR GeneTree; ENSGT00940000155174; -.
DR HOGENOM; CLU_412404_0_0_1; -.
DR OMA; FEDFGQE; -.
DR Proteomes; UP000245300; Unplaced.
DR GO; GO:0098793; C:presynapse; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0019992; F:diacylglycerol binding; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR CDD; cd20859; C1_Munc13-2-like; 1.
DR CDD; cd04027; C2B_Munc13; 1.
DR Gene3D; 1.10.357.50; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR010439; MUN_dom.
DR InterPro; IPR014770; Munc13_1.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR027080; Unc-13.
DR InterPro; IPR037302; Unc-13_C2B.
DR PANTHER; PTHR10480; PROTEIN UNC-13 HOMOLOG; 1.
DR PANTHER; PTHR10480:SF12; UNC-13, ISOFORM E; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF06292; MUN; 1.
DR PRINTS; PR00360; C2DOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM01145; DUF1041; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS51258; MHD1; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000245300};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 72..122
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 178..302
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 615..758
FT /note="MHD1"
FT /evidence="ECO:0000259|PROSITE:PS51258"
SQ SEQUENCE 770 AA; 88422 MW; 2FB436F4257395B5 CRC64;
GSGLYGIDSM PNLRRRKTIP LVSDVSLAAM QRKGGLLSSM ATRASLNDEE LKMHVYKKTL
QALIYPISCT IPHRFEVWTA TAPTYCYECE GLLWGIARQG MRCTECGVKC HEKCQDLLNA
DCLQRAAEKS SKHGAEDKTQ TIITAMKDRM KVRERNKPEI FDLIRDVFAV TPSDQNSHMK
SVKQMVLEGT SKWSAKITIN VHSAQGLQAK DKTGASDPYV TVQVGKTKKR TKTIYNNLNP
VWEEKFHFEC HNSSDRIKVR VWDEDDDIKS RVKQRLKRES DDFLGQTIIE VRTLSGEMDV
WYNLEKRTDK SVVSGAIRLQ ISVEIKGEEK VAPYHVQYTG LHENIFHFLT DVQNGGAVRI
PEAKGDEAWK VYFEETAQEI VDEFAMRYGI ESIYQAMTHF SCLSSKYMCS GVPAVMSNLL
ANINAYYAHT NTSTSNVSAS DRFAASNFGK DRFVKLLDQL HNSLRIDLSM YRNNFPASNR
ERLQDLKSTV DLLTSITFFR MKVQDLQSPP RASTVVKDCV KNSLSSTYEY IFANCHELYS
QEYQSADQTK DEAAPEEHGP SIKNLDFWPK LITLIVSIIE EDKNSYTPVL NQFPQELNVG
KVSAEVMWNL FSLDMRAAMQ VKEHEKHRQC KSADYMNLHF KVKWLYNEYV KDLPASKEKV
PEYSAWFEPF VLQWLDENEE VSLEFLRGAL DRDKKDGFQQ TSEHALFSCS VVDVFTQLNQ
SFEIIKKLEC PDPEIVAHFM RRFAKTISKV LMNYAEIISQ YFKEYCSQEK
//
