ID S4RUV8_PETMA Unreviewed; 1469 AA.
AC S4RUV8;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
OS Petromyzon marinus (Sea lamprey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000008998.1, ECO:0000313|Proteomes:UP000245300};
RN [1] {ECO:0000313|Ensembl:ENSPMAP00000008998.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2B subfamily. {ECO:0000256|ARBA:ARBA00006396}.
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DR STRING; 7757.ENSPMAP00000008998; -.
DR Ensembl; ENSPMAT00000009037.1; ENSPMAP00000008998.1; ENSPMAG00000008089.1.
DR GeneTree; ENSGT00940000156249; -.
DR HOGENOM; CLU_001645_0_1_1; -.
DR OMA; CENINPP; -.
DR Proteomes; UP000245300; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 3.
DR CDD; cd06263; MAM; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR24051:SF11; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR PANTHER; PTHR24051; SUSHI DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF00629; MAM; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00020; MAMDOMAIN.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00137; MAM; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50060; MAM_2; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000245300};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..26
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 747..768
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 25..188
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 285..380
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 385..483
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 484..590
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 918..1172
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1092..1163
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1204..1465
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1380..1456
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 362..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 471..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1469 AA; 163708 MW; C77DFE2076B9A86E CRC64;
RRGSQELLIT LLEVVVTALL LCIAGSCSFE DDFGACGYRQ DTDDTFDWEQ VNAREFPELE
GAIPHADVDT YMLANTSDRV PGQWATLRLP QIKKNDTHCL DFHYHLSAPG RLSPGTLNVY
VAVNGGPLAN PIWNASESMG RRWARAELAI STFWPNSYQV IFEAVSSGVE LGYIAIDDVQ
VHSYPCSKIR RFQQRTADAF VTFETFATGK ALTNELLWLQ RSNGQDIPVS GTKLVNHRRF
AASFGVPYAA RSHADIYRCV TGSADGAGVS NFAQLIVKGS EPPTPVAPPQ LVGAGATYLL
VQLNANSIAG DGPVVLREVE YRLPASVGGW AETHAVNAAT YKLWHLDPDT RYEVRVLLTR
PGEGGTGKSG PPLLARTKCA EPTRPPRGLL VTSVGSRKLS VEWERVGYNV TRCSNFSVAV
RCRYRRGGGG GGGGGGSGEA LRVLAQHTLY DLPPFTNISV RLVLSNPEGR KESEEIVTQT
DEDVPGPIPE DSIRGDTFED RIFLQWSCPT ETNGLISLYE ITYQAVSSFD PSLVAAARSG
VIHRASNETA HLFSGLFPGT SYAFTLRAST VKGYGPPVTV RLSTNISAPT LPRYEFDEPL
NETDTTITVL LQPAASKGAP VSAYQLVVKE NRQQQQQQQK PRASCFFEPI GFQAASARDS
PHYFAAELPP AALPSPSRFV VGDNRTYNGF WNAPLTPEKS YDVYFQAVSQ SAGEIKIDCV
RVGRKGASPR PPSAPAPERQ MDHTMRVAGI VAGSLALILV VMALLIIFRR RKMSKKRKEG
GNGGSRQEMT LMVHAMDKSF VEQSALHGEE PLAFLNAHNG TGRFVKKKSS KTCRTNALRT
EQRHNTSSDY FLTPLSLLLP LVSPDSVSIA VSATYRHRRP RDGPDSPAYH TGRLHPAVRV
ADLLEHIGQM KTGEGYGFKE EYESFFEGQS APWDVAKRDE NRAKNRYGNI IAYDHSRVML
NVLDEEQNSD YINANYVDGY YRTHHYIATQ GPLPDTVGGF WRMIWQERSA SIIMVTNLVE
VGRIKCCKYW PDGSDVYGDI KVTLADTEML SEYIIRTFRV ERAGQEDIRE VRQFHFTGWP
DHGVPYHATG LLAFIRRIKA LDPPHAGPLV VHCSAGAGRT GCYMVIDIML DMAESEGVID
IYNCVRELRT RRVNMVQTEE QYVFIHDAML EACLCGDTCI PAGDFRAAYA EMLRPDPQSS
SNHIKDEFQT LNMVTPPLRV EDCSIALLPR NHEKNRYHDV LPPDRCLPFL ITINGDSSNY
INAALMDSYR QPSAFIVTQH PLPNTVKDFW RLVFDYHCTS IVMLNELDSN KYCPQYWPEE
GMLCHGPIQV EFVAFNMEGD IITRTFRICN VARPQDGCRM VEQFHYLGWP AGREVPTSRH
SFLRLVLAAE RWREEYGMDG RTVVHCLNPP PRLLSLPLLS LMATANNHMY QIIITELVEK
IMAIYKGLVN LQSQYQFCYD VALEYLETV
//
