ID S4RW86_PETMA Unreviewed; 323 AA.
AC S4RW86;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPMAP00000009476.1};
OS Petromyzon marinus (Sea lamprey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000009476.1, ECO:0000313|Proteomes:UP000245300};
RN [1] {ECO:0000313|Ensembl:ENSPMAP00000009476.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; S4RW86; -.
DR STRING; 7757.ENSPMAP00000009476; -.
DR Ensembl; ENSPMAT00000009516.1; ENSPMAP00000009476.1; ENSPMAG00000008606.1.
DR GeneTree; ENSGT01030000234571; -.
DR HOGENOM; CLU_012820_0_0_1; -.
DR OMA; ECNENAR; -.
DR Proteomes; UP000245300; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd01221; PH_ephexin; 1.
DR CDD; cd11793; SH3_ephexin1_like; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR047271; Ephexin-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047270; PH_ephexin.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12845; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR12845:SF6; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 19; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000245300};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..75
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 108..223
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 235..297
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
SQ SEQUENCE 323 AA; 37075 MW; 36AC56DAFCF38F46 CRC64;
TNAKFSPLLE HLQEDPICNR LSLQSFLILP FQRIVRIKIL LENILKKTEP HSRYEETASV
ALKALARLIQ ECNENARKMK RTEELIHLHN TIEFDKMKSL ALISPTRWLV KHGELLELAV
SRTAGSTLMN RLMTKRIYLH LFNDILILSR RKDSGGKFTV FCHADRTKVE LQSVGAAENN
VATDNSFYLL LDDHDSRKYR LLLRAASQSE KERWVEAIAP PQRKDEAALV YEGVTDCPQV
YCLKAYVAQE PDELSLDKGD ILSITRKTSD GWMEGVRLSD AEKGGWFPTA NVAEITNVHV
RTRNIRDHHR LQLATQNLQR KHS
//
