ID S4RXD2_PETMA Unreviewed; 628 AA.
AC S4RXD2;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Small monomeric GTPase {ECO:0008006|Google:ProtNLM};
OS Petromyzon marinus (Sea lamprey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000009872.1, ECO:0000313|Proteomes:UP000245300};
RN [1] {ECO:0000313|Ensembl:ENSPMAP00000009872.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the centaurin gamma-like family.
CC {ECO:0000256|ARBA:ARBA00005430}.
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DR AlphaFoldDB; S4RXD2; -.
DR STRING; 7757.ENSPMAP00000009872; -.
DR Ensembl; ENSPMAT00000009914.1; ENSPMAP00000009872.1; ENSPMAG00000008958.1.
DR GeneTree; ENSGT00940000154793; -.
DR HOGENOM; CLU_007326_4_0_1; -.
DR Proteomes; UP000245300; Unplaced.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR CDD; cd01250; PH_AGAP; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR45819; CENTAURIN-GAMMA-1A; 1.
DR PANTHER; PTHR45819:SF5; CENTAURIN-GAMMA-1A; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000245300};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 270..511
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 532..616
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REGION 210..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 427..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 628 AA; 67826 MW; A14E304163486ED4 CRC64;
GIVGTCGCGK SALVHRFLTG AYVREESPEG GRFKKEMVAD GQSLLLLIRD EGAPPTEQFA
SWLDGVMLVF ALSDETSFQS VARYHQQLSS LCSLSELPTL LVGTQVVPAD AIGPGSPRTV
EDARARRLCS ELRIGTYYET CATYGLNVER VFQEVAQRIV ATRKKQQLSI GLCKPMVTPP
SASALHGGLY SQTHVAAAAT AAVIPALSSS SASTPASTER EMRIDGAITP TSSRKQPRRR
SIFTSRKVNL DGERRNDVGK TDIIGSGREI PIKQGFLMKR SSSSLNKEWK KKYVTLCDSG
TLTYHPSLQD YMQNVHGKAI DLLRTTVKVP GKRPPRASSS RCIPVIHKPT FRGIAFEGRS
LDVRERALCV TPASATKRVP SERSASTTSL AMHQRSASLC SSEHWIDGGA FGEAASALAS
GPFPGLASSP MVPGSPTGRR DVPPSPHAAR RKGRWNKTVR NGRPEGSTNS EDPEETFEFV
LVSLSGQTWH FEAPSWEERD AWVQAIEGRI LASLQSCDSR KTKTRLGSQG SAVAAQNIRD
VQGNDVCIDC GAPNPDWASL NLGALICIEC SGIHRNLGSH VSRVRSLDLD EWPDELAQVM
VSVGNAMSRG VWEGSLAGHA KPGPRSSR
//
