ID S4RXN0_PETMA Unreviewed; 260 AA.
AC S4RXN0;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Calpain catalytic domain-containing protein {ECO:0000259|PROSITE:PS50203};
OS Petromyzon marinus (Sea lamprey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000009971.1, ECO:0000313|Proteomes:UP000245300};
RN [1] {ECO:0000313|Ensembl:ENSPMAP00000009971.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C2 family.
CC {ECO:0000256|ARBA:ARBA00007623}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00239}.
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DR AlphaFoldDB; S4RXN0; -.
DR STRING; 7757.ENSPMAP00000009971; -.
DR Ensembl; ENSPMAT00000010015.1; ENSPMAP00000009971.1; ENSPMAG00000009061.1.
DR GeneTree; ENSGT00940000156092; -.
DR HOGENOM; CLU_010982_3_0_1; -.
DR OMA; CETIICI; -.
DR Proteomes; UP000245300; Unplaced.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00214; Calpain_III; 1.
DR Gene3D; 2.60.120.380; -; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR033883; C2_III.
DR InterPro; IPR022684; Calpain_cysteine_protease.
DR InterPro; IPR022682; Calpain_domain_III.
DR InterPro; IPR022683; Calpain_III.
DR InterPro; IPR036213; Calpain_III_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR PANTHER; PTHR10183; CALPAIN; 1.
DR PANTHER; PTHR10183:SF379; CALPAIN-A-RELATED; 1.
DR Pfam; PF01067; Calpain_III; 1.
DR Pfam; PF00648; Peptidase_C2; 1.
DR PRINTS; PR00704; CALPAIN.
DR SMART; SM00720; calpain_III; 1.
DR SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000245300}.
FT DOMAIN 1..86
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT ACT_SITE 3
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1"
FT ACT_SITE 27
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1"
SQ SEQUENCE 260 AA; 29540 MW; 1E9C16BC91842224 CRC64;
MGHAYAVLGV YSVTVNGSRV RLLRLRNPWG YQEYSGSWND CSPEWNAVSC EEKERLRLQR
EDDGEFWMSW CDFVHCFSNV EICSLSPHGG GATGWALATH EGRWVPGCTA GGCRKFEGTF
WTNPQFRLTL CEEDDDDSDD DGDGLEDHGD VTCTVVVALM QKNRRVFKRG ARSTFLHIGF
SIYSIPPEAS QKKLHLIFLF FAAARRVHES RAFANAREVT ARLVLPRGAY VLVPSTYRPG
EPGDFFLRTF AKRDNRSWRV
//
