ID S4RYI6_PETMA Unreviewed; 3556 AA.
AC S4RYI6;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=CUB and Sushi multiple domains 1 {ECO:0008006|Google:ProtNLM};
OS Petromyzon marinus (Sea lamprey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000010277.1, ECO:0000313|Proteomes:UP000245300};
RN [1] {ECO:0000313|Ensembl:ENSPMAP00000010277.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR STRING; 7757.ENSPMAP00000010277; -.
DR Ensembl; ENSPMAT00000010323.1; ENSPMAP00000010277.1; ENSPMAG00000009333.1.
DR GeneTree; ENSGT00940000155701; -.
DR HOGENOM; CLU_000277_0_0_1; -.
DR OMA; IIVACDM; -.
DR Proteomes; UP000245300; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00033; CCP; 28.
DR CDD; cd00041; CUB; 13.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 28.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 13.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR45656:SF4; PROTEIN BETA CHAIN, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR45656; PROTEIN CBR-CLEC-78; 1.
DR Pfam; PF00431; CUB; 13.
DR Pfam; PF00084; Sushi; 27.
DR SMART; SM00032; CCP; 28.
DR SMART; SM00042; CUB; 13.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 28.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 13.
DR PROSITE; PS01180; CUB; 13.
DR PROSITE; PS50923; SUSHI; 28.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000245300};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 3480..3501
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 9..70
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 74..178
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 322..383
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 386..497
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 500..557
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 559..667
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 670..731
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 733..842
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 847..904
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 906..1016
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1019..1078
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1080..1188
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1191..1251
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1253..1365
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1368..1428
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1430..1538
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1541..1602
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1604..1712
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1718..1779
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1781..1889
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1892..1953
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1955..2063
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2066..2125
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2127..2238
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2237..2298
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2300..2412
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2412..2474
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2475..2536
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2537..2601
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2602..2659
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2660..2717
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2718..2775
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2776..2837
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2838..2895
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2899..2956
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2957..3015
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3016..3075
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3076..3133
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3134..3191
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3197..3255
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3256..3315
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT REGION 225..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 306..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 528..555
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 875..902
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1253..1280
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 2630..2657
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2688..2715
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2746..2773
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2808..2835
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2866..2893
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2927..2954
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2986..3013
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3104..3131
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3162..3189
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3226..3253
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 3556 AA; 386979 MW; 0C7432A5265914B4 CRC64;
IYLQVLQIHS CGNPGVPPDG IMHGEHFNIG DKVRYSCAKG HVLEGQPIVT CVVYSGNNVA
WDFPIPQCRA EGACGRTLRE NSGVISSPNY PSEYGNDADC TWIVLAEQGD TISLVFNDFQ
LEERFDSLEV EGADPSSIWL TGVGLPSPMI SSKNWLRLHF VSNSNNSLRG FTAQYQVNQN
LKSNTLTSET ERSILPREEA LAKCGTRLLK EITVKVTTQN LLNRSSNSAG RTVTQNSRPH
ADRQTGKYFL PPPPAQDASL NPAQSRHAHG NHVKLNFKIY IVQRAVKRAI DLRTKGGKVT
QIKDKAKYSM TGKNRSSTHA SSTCPDPGEP QDGRRVGADF RLGATVRFSC NEGYVLQGSS
SIICQRVNEI FASWSDNTPK CKGITCGAAL TGPSGTITSP NFPVQYDNNA QCVWTITASR
PSKVIEINFE EFDLERGFDT LTVGDGEEVG DPRMVLHVLT GTSVPDLVVS MTGHMWLHLQ
TDDSAGSLGF KIIYREIAER SCGDPGVPQH GRREGSGFSH RDSLTFECQA AFELVGEKTI
TCQSNNQWSA NVPHCIFPCV FNFTSPIGIV LSPNYPEHYG SNMNCIWLIV APAGSRIRLV
FADFEVESQF DFLAVKDGDR HDAPLLGTFS GADVPGNLVS ASNTFRLEFL SDHSTPGRGF
NISYTTFGHN DCYDPGNPVN GRRFGTKFHL GSMVSFTCEK GFIRTEGSEI LTCVSRDGNI
EWNENVPKCE APCGGHLTSL AGIILSPGWP GLYKDSLSCE WIIEAQQGHA IRLIFKSRFQ
TEVNYDVLQI YDGASTSSPL TGSFHGTQVP EFLASTGNTL LLHFTTDNSR SNVGFQILYE
SITLSTHLCL DPGVPVHGQR HGTEMSVGSM VTFSCNSGYT LSHEEALICD KNLQWSHPMA
SCDAPCGGYI HASSGIILSP GYPDYYPNTL NCTWTVEVSH GKGVQFTFHT FHLESSHDYL
LITENGSFSQ PLARLTGSTL PPVLHAGVYG NFQAQLRFIS DFSMSYEGFN ITFTEYNLEP
CKDPGMPAYS RREGSTFTVG DVLSFSCFAG YRLVGMPKLT CQGGGRHVWS SPLPRCVAEC
GMSSIGTDGE LLSPNYPGSY DRKHECIYTI ETEAGSGIRL MAKTFRVAEG DFLKVYDGNS
SLAPLIGTYS KTEFQGLSLN STSNRLWLKF DTDSEGTEKG FRLIYSSFEL THCKEPGSPE
FGYKIREQGH FAGGTVAYGC NPGYNLHGSS TLTCMTGSRR TWDHQLPSCV AECGGKIQGA
TSGRILSPGY PAPYGHNLQC TWEIHANAGY TISLHFVVFD TEAAHDLLKV WDGPSVPSQA
GVLLKELSGS VLPDDIHSSQ SSLSLHFQSD FFISKTGFAI QFSSAVARAC RDPGVPTNST
RSGTGREPGN IITFQCQPGY QLQGEATIVC MHGENHYYWQ PDPPTCIAPC GGNLTEPTGF
ILSPNYPEPY PPGKECDWQV TVTADNVISL TFISFDTETS YDFLHIYDGP GSSSPLIASL
QGSKLPGRIE STGNSMFMAF RSDDSLSLSG FHIEYKEKPQ ESCFDPGNIQ NGSRLGTDVK
LRSTITYFCD AGYTIQGYST LLCVMSEDGR PMWNRPLPSC HAPCGGKATA SEGVVLSPGY
PRNYSSPQHC VHTITVPKDF VIFGQYATFE TSVKDVVHVY DGPTQSFFLL SALSGSHTGK
VIPLSSSHQI TIVFSPSKGS SARGYHFVYR AVPRTSATHC TSISEPLHGR RIGLDFSANS
IVRFECNPGY TLKGAQAIQC TTVANALAQW NDSLPTCYAP CGGNLTIYTG TILSPGYPEM
YDNNLDCVWR IIVPEGDGIQ VQFVNFATEH NWDTLDIYDG PDVNSPKLGS FSGTTVPTFI
NSSSNQLYLH YQTDLSLGIV GFHVKYSAIG LSSCSEPNTP SNGIKMGNSF LVNDIMSFEC
EPGFKLQTQG HKHIMCMPGP VRRWNFPPPI CTAVCGGTMT EFNGIILSPD FPGNYPSNVE
CHWKIELPIG YGVYLQFENF TTELDHDYLE IRTEIAQVSS TIGRFSGPTV PAALLSTTHR
TTMHFHSDYS QSKPGFKIFY EAYELQNCPD PKPFRNGFVV GSNFGVGHSI SFECFSGYVL
IGQSILTCQH GVNRNWDHPF PSCIAPCGGN VTGMSGTVYS PGFPDEYPNF QDCVWMVKVA
YGHGVYINFT LLRTEPVYDF ITIWDGPEQN APQLGQFSGN TALESVYSTS NQILLKFHSD
FSTGGFFVLS YYAYQLRVCQ LPPSVPHAET LMQDKELEIG DTVHYRCEAG FTMLYSDVLT
CQLRARLQMD TTPPACEALC PTNEVRTESV GVILSPSYPA NYPYLQTCLW TISVEKTYNV
TLFIELFQSE KQYDELEIFD GGQSSQSPRL LALSGDYSAP ISVTSTGHQV HLRWASDQAT
SKKGFRIRYT AEYCSIPAAP AHGSVMSQSG GHLNSVVWWA CDRGYTLIGK SSAVCIKAPQ
GFHMWDSAVP TCQAISCGIP VSPANGEILT VNYSIGGRVT YGCNRGYTTG PGDTLAAVCL
ENGTWSNNNQ PPMCNAIACM DFNAFSLDHG SWLLLNGSDY KYGSRIIFHC QPGYTLLGPR
IIQCQENGAW SWENDRPRCS LISCGSLSAL PNGRKIGTQT GFGSTAIYRC DPGFTLLGSQ
VRECLASGLW SGTSNRCIAG HCGVPDPVTN GAVVGQSFGY HDTVVYRCQP GFRLVGSSVR
MCQQDHQWSG QPPACVPISC GHPGTPVHGL TEGSSFHLYD TVNFTCNSGY ISEGASQAQC
MPDALWSQPL PTCKVVSCPD PGEPLNGVRK VNKGYGKFVF GSVVFYDCKQ GFYLIGSSVL
TCLPNGLWDR PIPQCFLVSC GHPGVAPNSL LSGEKFTFGA TVIYSCTGSR LLIGNATRSC
QADGRWTGAQ PHCSGDSAGS CGDPGIPSHG HRIGEEFRVK SVVRFGCAVG YALHGPSERV
CLPSGSWSRS QAECKAVWCG NPGVPAGGSI LHSDGVVFSS SVTYACWDGY QMSGLSTRLC
SANATWTGVL PVCTVISCGN PGVAANGFYL GKEFTFSQNV SYHCYPGYSM SSGATAVRSC
QKDGTWSGAL PSCHVITCRQ PPRVLNGRLL GSDFSWGASV SYSCSSGYEP SFPATLTCEG
NGTWRGDVPQ CLPIYCGDPG VPAEGRREGT SFMYKSKVAF SCKNTLLLVG SSLRMCTADG
TWSGTQPRCI DLDPLQNTCP NPGALQFGEL NSTFGFQVGS KVKFRCGKGY HILGSTTRSC
QSDYVWSGTR PQCIPHSCRQ LETPENADVG AVELPGLGYT LMYSCQPGFY LAGGSEHRSC
RPDGTWSGKT PICHPGLKPS EKNNSALLTT HSPQGAALDV TLFEESVWKG SFDFRDTKRP
ASLLTNSIDV NSGRLNLTFL ATNMELKVAG VFKNKEGNVF LRVTHVKRFD QSLFEKMPGD
WSMNGSVTTD IDGVTHVYQG FIQAKEYGSF GFKKIGAETR GPEGGTDPTG QQHGTSSSSV
AVAILVPFFA LILAGFAFYL YKQRSAPKPH FSGFADHENS NGQTAFENMI YDSSLKHGES
KAVRFDPRLN TVCTVV
//
