ID   S4WZT5_BCHK5            Unreviewed;       934 AA.
AC   S4WZT5;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   28-JUN-2023, entry version 33.
DE   RecName: Full=ORF1ab polyprotein {ECO:0000256|PROSITE-ProRule:PRU01344};
DE   Flags: Fragment;
OS   Bat coronavirus HKU5 (BtCoV) (BtCoV/HKU5/2004).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC   Betacoronavirus; Merbecovirus.
OX   NCBI_TaxID=694008 {ECO:0000313|EMBL:AGP04959.1};
OH   NCBI_TaxID=105295; Pipistrellus abramus (Japanese pipistrelle) (Pipistrellus javanicus abramus).
RN   [1] {ECO:0000313|EMBL:AGP04959.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=18R {ECO:0000313|EMBL:AGP04959.1};
RX   PubMed=23720729; DOI=10.1128/JVI.01055-13;
RA   Lau S.K., Li K.S., Tsang A.K., Lam C.S., Ahmed S., Chen H., Chan K.H.,
RA   Woo P.C., Yuen K.Y.;
RT   "Genetic Characterization of Betacoronavirus Lineage C Viruses in Bats
RT   Reveals Marked Sequence Divergence in the Spike Protein of Pipistrellus Bat
RT   Coronavirus HKU5 in Japanese Pipistrelle: Implications for the Origin of
RT   the Novel Middle East Respiratory Syndrome Coronavirus.";
RL   J. Virol. 87:8638-8650(2013).
RN   [2] {ECO:0000313|EMBL:AGP04959.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=18R {ECO:0000313|EMBL:AGP04959.1};
RA   Lau S.K.P., Li K.S.M., Tsang A.K.L., Lam C.S.F., Shek C.-T., Wang M.,
RA   Ahmed S., Chan K.-H., Zheng B.-J., Woo P.C.Y., Yuen K.-Y.;
RL   Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the coronaviruses polyprotein 1ab family.
CC       {ECO:0000256|ARBA:ARBA00008087, ECO:0000256|PROSITE-ProRule:PRU01344}.
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DR   EMBL; KC522077; AGP04959.1; -; Genomic_RNA.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR   GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR044863; NIRAN.
DR   InterPro; IPR047570; NSP12_IF_CoV.
DR   InterPro; IPR046441; RdRp_CoV.
DR   InterPro; IPR009469; RdRp_N_CoV.
DR   InterPro; IPR001205; RNA-dir_pol_C.
DR   InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR   Pfam; PF06478; CoV_RPol_N; 1.
DR   Pfam; PF00680; RdRP_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS52000; COV_NSP12_IF; 1.
DR   PROSITE; PS51948; COV_NSP12_RDRP; 1.
DR   PROSITE; PS51947; NIRAN; 1.
DR   PROSITE; PS50507; RDRP_SSRNA_POS; 1.
PE   3: Inferred from homology;
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Ribosomal frameshifting {ECO:0000256|ARBA:ARBA00022758};
KW   RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW   ECO:0000313|EMBL:AGP04959.1}; Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Viral RNA replication {ECO:0000256|ARBA:ARBA00022953}.
FT   DOMAIN          6..263
FT                   /note="NiRAN"
FT                   /evidence="ECO:0000259|PROSITE:PS51947"
FT   DOMAIN          268..366
FT                   /note="Nsp12 Interface"
FT                   /evidence="ECO:0000259|PROSITE:PS52000"
FT   DOMAIN          367..934
FT                   /note="Nsp12 RNA-dependent RNA polymerase"
FT                   /evidence="ECO:0000259|PROSITE:PS51948"
FT   DOMAIN          614..776
FT                   /note="RdRp catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50507"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AGP04959.1"
FT   NON_TER         934
FT                   /evidence="ECO:0000313|EMBL:AGP04959.1"
SQ   SEQUENCE   934 AA;  107008 MW;  E558DC6E0FF38AB8 CRC64;
     SKDSNFLNRV RGSIVNARIE PCASGLTTDV VFRAFDICNY KAKVAGIGKY YKTNTCRFVE
     VDDEGHRLDS FFVVKRHTME NYELEKRCYD LVKDCDAVAV HDFFIFDVDK VKTPHIVRQR
     LTEYTMMDLV YALRHFDQNN CEVLKSILVK YGCCDASYFD NKLWFDFVEN PNVISVYHKL
     GERIRQAVLN TVKFCDQMVK SGLVGVLTLD NQDLNGKWYD FGDFVITQPG AGVAIVDSYY
     SYLMPVLSMT NCLAAETHRD CDLTKPLIEW PLLEYDYTDY KIGLFEKYFK HWDQQYHPNC
     VNCTDDRCVL HCANFNVLFS MTLPGTSFGP IVRKIFVDGV PFVISCGYHY KELGLVMNMD
     VSLHRHRLSL KELMMYAADP AMHIASASAL WDLRTPCFSV AALTTGLTFQ TVRPGNFNKD
     FYDFVVSKGF FKEGSSVTLR HFFFAQDGHA AITDYSYYAY NLPTMCDIKQ MLFCMEVVDR
     YFEIYDGGCL NASEVIVNNL DKSAGHPFNK FGKARVYYES LSYQEQDELF AMTKRNVLPT
     ITQMNLKYAI SAKNRARTVA GVSILSTMTN RQYHQKMLKS MAATRGSTCV IGTTKFYGGW
     DFMLKTLYKD VDNPHLMGWD YPKCDRAMPN MCRIFASLIL ARKHSTCCTN TDRFYRLANE
     CAQVLSEYVL CGGGYYVKPG GTSSGDATTA YANSVFNILQ ATTANVSALM GANGNTIVDK
     EVKDMQFELY VNVYRKSQPD PKFVDRYYAF LNKHFSMMIL SDDGVVCYNS DYATKGYIAS
     IQNFKETLYY QNNVFMSEAK CWVETDLKKG PHEFCSQHTL FIKDGDDGYF LPYPDPSRIL
     SAGCFVDDIV KTDGTLMVER FVSLAIDAYP LTKHDDPEYQ NVFWVYLQYI EKLYKDLTGH
     MLDSYSVMLC GDNSAKFWEE SFYRDLYTAP TTLQ
//