ID S4XT10_SORCE Unreviewed; 682 AA.
AC S4XT10;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=SCE1572_11140 {ECO:0000313|EMBL:AGP35015.1};
OS Sorangium cellulosum So0157-2.
OC Bacteria; Myxococcota; Polyangia; Polyangiales; Polyangiaceae; Sorangium.
OX NCBI_TaxID=1254432 {ECO:0000313|EMBL:AGP35015.1, ECO:0000313|Proteomes:UP000014803};
RN [1] {ECO:0000313|EMBL:AGP35015.1, ECO:0000313|Proteomes:UP000014803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=So0157-2 {ECO:0000313|EMBL:AGP35015.1,
RC ECO:0000313|Proteomes:UP000014803};
RX PubMed=23812535; DOI=10.1038/srep02101;
RA Han K., Li Z.F., Peng R., Zhu L.P., Zhou T., Wang L.G., Li S.G.,
RA Zhang X.B., Hu W., Wu Z.H., Qin N., Li Y.Z.;
RT "Extraordinary expansion of a Sorangium cellulosum genome from an alkaline
RT milieu.";
RL Sci. Rep. 3:2101-2101(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR EMBL; CP003969; AGP35015.1; -; Genomic_DNA.
DR RefSeq; WP_020734202.1; NC_021658.1.
DR AlphaFoldDB; S4XT10; -.
DR STRING; 1254432.SCE1572_11140; -.
DR KEGG; scu:SCE1572_11140; -.
DR PATRIC; fig|1254432.3.peg.2490; -.
DR eggNOG; COG0515; Bacteria.
DR HOGENOM; CLU_025729_0_0_7; -.
DR OrthoDB; 5489674at2; -.
DR Proteomes; UP000014803; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd14014; STKc_PknB_like; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR43289; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED; 1.
DR PANTHER; PTHR43289:SF6; SERINE_THREONINE-PROTEIN KINASE NEKL-3; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF13676; TIR_2; 1.
DR SMART; SM00220; S_TKc; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}.
FT DOMAIN 1..143
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT DOMAIN 231..478
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT COILED 162..196
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 261
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 682 AA; 73989 MW; EC629F4DD6D340AC CRC64;
MAVNVFISYA PADRPHLEAL EAHLAALKRQ GLVSTWHRGR IGAGAVRDAS IAAELSAAEV
VLLLVSEAFL ASDSCYEREL GAALERHRRG EARVVPILVR ACDREGTALA DLEALPRDGG
AVTSWANPDE AWRDVVRGVR AAVEEAAASA RPEAAPARAA PASALAATLR EAEEAIRAID
KQIAAAQKRR VRLKAAGAST VEVDQEIVDL RRKRREGGQL HVGEELSEGR YLLLERIGRG
GFATVWRALD AGRGDQPVAI KVLHPNLAGD EGRRERFFRG ARAMAELDHP GVVRILEPKG
EDGGWHYFVM ELVHGEDVQS AVVGKRLPAE GVIPMILRAG EAISFAHGRG LVHRDVKPAN
ILLDGEGLPR ITDFDLVWAR DTTGGTRSGA LGTFLYAAPE LMHRPQDADA RADVYGLGMT
AVFCLHGGEL PPIMMRYPGR VIERLPCGDA VRKVLERAIE FEASERYPDV AAFCEALRGA
AESEGGPARE GSSGTGILQG EAGLQAHERS RRLPGGLVEA FERELGEGGP IRRTLKQIMV
AGEQLELAVP PASPVAGTNK TRHSLGTSTL RFHVSRDEEH VRIEAVWGDG ARQLGELTAF
YALLLLARER RKDAAVCLPE DEQGWIHEAD LAEQLGVEKK HLNVLIYRAR RAFADAGLGT
EIVERRRQAI RIATGRVEEL KA
//
