ID S5M0U0_9MOLU Unreviewed; 447 AA.
AC S5M0U0;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex {ECO:0000256|RuleBase:RU003423};
DE EC=2.3.1.- {ECO:0000256|RuleBase:RU003423};
GN Name=pdhC {ECO:0000313|EMBL:AGR41622.1};
GN ORFNames=STAIW_v1c10390 {ECO:0000313|EMBL:AGR41622.1};
OS Spiroplasma taiwanense CT-1.
OC Bacteria; Mycoplasmatota; Mollicutes; Entomoplasmatales; Spiroplasmataceae;
OC Spiroplasma.
OX NCBI_TaxID=1276220 {ECO:0000313|EMBL:AGR41622.1, ECO:0000313|Proteomes:UP000014984};
RN [1] {ECO:0000313|EMBL:AGR41622.1, ECO:0000313|Proteomes:UP000014984}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT-1 {ECO:0000313|EMBL:AGR41622.1};
RX PubMed=23873917; DOI=10.1093/gbe/evt108;
RA Lo W.S., Ku C., Chen L.L., Chang T.H., Kuo C.H.;
RT "Comparison of metabolic capacities and inference of gene content evolution
RT in mosquito-associated Spiroplasma diminutum and S. taiwanense.";
RL Genome Biol. Evol. 5:1512-1523(2013).
CC -!- COFACTOR:
CC Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC Evidence={ECO:0000256|ARBA:ARBA00001938,
CC ECO:0000256|RuleBase:RU003423};
CC -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00007317, ECO:0000256|RuleBase:RU003423}.
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DR EMBL; CP005074; AGR41622.1; -; Genomic_DNA.
DR RefSeq; WP_020834761.1; NC_021846.1.
DR AlphaFoldDB; S5M0U0; -.
DR STRING; 1276220.STAIW_v1c10390; -.
DR KEGG; stai:STAIW_v1c10390; -.
DR PATRIC; fig|1276220.3.peg.1056; -.
DR eggNOG; COG0508; Bacteria.
DR HOGENOM; CLU_016733_10_0_14; -.
DR OrthoDB; 9805770at2; -.
DR Proteomes; UP000014984; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR CDD; cd06849; lipoyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 4.10.320.10; E3-binding domain; 1.
DR InterPro; IPR003016; 2-oxoA_DH_lipoyl-BS.
DR InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR036625; E3-bd_dom_sf.
DR InterPro; IPR004167; PSBD.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR43178; DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX; 1.
DR PANTHER; PTHR43178:SF5; LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL; 1.
DR Pfam; PF00198; 2-oxoacid_dh; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF02817; E3_binding; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 1.
DR SUPFAM; SSF47005; Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS00189; LIPOYL; 1.
DR PROSITE; PS51826; PSBD; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003423};
KW Lipoyl {ECO:0000256|ARBA:ARBA00022823, ECO:0000256|RuleBase:RU003423};
KW Pyruvate {ECO:0000313|EMBL:AGR41622.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000014984};
KW Transferase {ECO:0000256|RuleBase:RU003423, ECO:0000313|EMBL:AGR41622.1}.
FT DOMAIN 1..76
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
FT DOMAIN 143..180
FT /note="Peripheral subunit-binding (PSBD)"
FT /evidence="ECO:0000259|PROSITE:PS51826"
FT REGION 79..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 447 AA; 47756 MW; 4612CBBFD7FEEBCA CRC64;
MFKVKFADIG EGLTEGTVTE VLVKVGDSVK MGDSLFNVET DKVTSDIYAP VDGKIAKILI
SAKQEIKVGD VVIEIDDGKG EATAEPEKKS SSNVQPVEEN ASVVGATPVS NDLISRDTNR
NVATKQTISN QASIIDNSHV DVKASPLARK IAAVMGVDLS KVTPTGPNGR ILANDIQSFA
ANPAKSAPVA FVGGASAKQQ IDYSNPLISV PEINEPLTFE SKPWNPIRKA TVKAMTTAHE
KVAGFTGLRN LDVTELVNIR KQLKAFADSQ RVKLTYLAFI IKACANALKD MPNLNVRIDE
ENKATKFAQQ INIGMACDTP DGLMVPVIKG ADKLSVLQIA VKINDLAMKA RSKKLASNEM
SGATFTVTNF GAVGLDYATP IVNFPESAIL GVGTITRAPG VINDKIEIRD FMPFSITADH
KVIDGADAGR FLTKVAYYLQ NPATLLV
//
