ID S5M1Y7_9MOLU Unreviewed; 320 AA.
AC S5M1Y7;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=GMP reductase {ECO:0000256|ARBA:ARBA00015800};
DE EC=1.7.1.7 {ECO:0000256|ARBA:ARBA00012678};
DE AltName: Full=Guanosine 5'-monophosphate oxidoreductase {ECO:0000256|ARBA:ARBA00030699};
GN Name=guaC {ECO:0000313|EMBL:AGR42087.1};
GN ORFNames=SDIMI_v3c03830 {ECO:0000313|EMBL:AGR42087.1};
OS Spiroplasma diminutum CUAS-1.
OC Bacteria; Mycoplasmatota; Mollicutes; Entomoplasmatales; Spiroplasmataceae;
OC Spiroplasma.
OX NCBI_TaxID=1276221 {ECO:0000313|EMBL:AGR42087.1, ECO:0000313|Proteomes:UP000014983};
RN [1] {ECO:0000313|EMBL:AGR42087.1, ECO:0000313|Proteomes:UP000014983}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CUAS-1 {ECO:0000313|EMBL:AGR42087.1};
RX PubMed=23873917; DOI=10.1093/gbe/evt108;
RA Lo W.S., Ku C., Chen L.L., Chang T.H., Kuo C.H.;
RT "Comparison of metabolic capacities and inference of gene content evolution
RT in mosquito-associated Spiroplasma diminutum and S. taiwanense.";
RL Genome Biol. Evol. 5:1512-1523(2013).
CC -!- FUNCTION: Catalyzes the irreversible NADPH-dependent deamination of GMP
CC to IMP. It functions in the conversion of nucleobase, nucleoside and
CC nucleotide derivatives of G to A nucleotides, and in maintaining the
CC intracellular balance of A and G nucleotides.
CC {ECO:0000256|ARBA:ARBA00037691}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH;
CC Xref=Rhea:RHEA:17185, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58053, ChEBI:CHEBI:58115,
CC ChEBI:CHEBI:58349; EC=1.7.1.7;
CC Evidence={ECO:0000256|ARBA:ARBA00000930};
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DR EMBL; CP005076; AGR42087.1; -; Genomic_DNA.
DR RefSeq; WP_020836320.1; NC_021833.1.
DR AlphaFoldDB; S5M1Y7; -.
DR STRING; 1276221.SDIMI_v3c03830; -.
DR KEGG; sdi:SDIMI_v3c03830; -.
DR PATRIC; fig|1276221.3.peg.380; -.
DR eggNOG; COG0516; Bacteria.
DR HOGENOM; CLU_022552_5_0_14; -.
DR InParanoid; S5M1Y7; -.
DR OrthoDB; 9805398at2; -.
DR Proteomes; UP000014983; Chromosome.
DR GO; GO:1902560; C:GMP reductase complex; IEA:InterPro.
DR GO; GO:0003920; F:GMP reductase activity; IEA:InterPro.
DR GO; GO:0006163; P:purine nucleotide metabolic process; IEA:InterPro.
DR CDD; cd00381; IMPDH; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR HAMAP; MF_01511; GMP_reduct_type2; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR005994; GuaC_type_2.
DR InterPro; IPR015875; IMP_DH/GMP_Rdtase_CS.
DR InterPro; IPR001093; IMP_DH_GMPRt.
DR NCBIfam; TIGR01306; GMP_reduct_2; 1.
DR PANTHER; PTHR43170; GMP REDUCTASE; 1.
DR PANTHER; PTHR43170:SF5; GMP REDUCTASE; 1.
DR Pfam; PF00478; IMPDH; 1.
DR PIRSF; PIRSF036500; GMP_red_Firmic; 1.
DR SMART; SM01240; IMPDH; 1.
DR SUPFAM; SSF51412; Inosine monophosphate dehydrogenase (IMPDH); 1.
DR PROSITE; PS00487; IMP_DH_GMP_RED; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000014983}.
FT DOMAIN 4..313
FT /note="IMP dehydrogenase/GMP reductase"
FT /evidence="ECO:0000259|Pfam:PF00478"
SQ SEQUENCE 320 AA; 35582 MW; 6AF0D56F7C24C0B6 CRC64;
MYAFDYEDIQ LIPSMCVVNS RSECNTEVTL GKHTFKMPVM PANMASVINE ELCEMLARNG
HFYVMHRFNV DSYAFTKKMN QENLISSISV GVKKEDYELI EKLANDNVVP DYITIDIAHG
HSLSVKNMIE HIRKHMKNNT FIIAGNVGTP HAVRDLEFWG ADATKVGVGP GKVCITKLKT
GFGTGGWQLG AIKWCSKASH KPIIADGGLR VNGDIAKSIR FGATMCMIGS LFAAHEESPG
ANVTVDGVMF KEYYGSASEY NKGEKRYVEG KKELIKVRGK LMETYKEMQE DLQSSISYSG
GTTLNDIKKV DYVILKTSNF
//
