ID S5M5M0_9ROSA Unreviewed; 580 AA.
AC S5M5M0;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 22-FEB-2023, entry version 24.
DE RecName: Full=Beta-hexosaminidase {ECO:0000256|PIRNR:PIRNR001093};
DE EC=3.2.1.52 {ECO:0000256|PIRNR:PIRNR001093};
GN Name=HEX {ECO:0000313|EMBL:AGR44467.1};
OS Pyrus x bretschneideri (Chinese white pear).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Maleae; Pyrus.
OX NCBI_TaxID=225117 {ECO:0000313|EMBL:AGR44467.1};
RN [1] {ECO:0000313|EMBL:AGR44467.1}
RP NUCLEOTIDE SEQUENCE.
RA Cheng Y., Guan J., He J.;
RT "Cell wall metabolism associated genes.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine
CC residues in N-acetyl-beta-D-hexosaminides.; EC=3.2.1.52;
CC Evidence={ECO:0000256|ARBA:ARBA00001231,
CC ECO:0000256|PIRNR:PIRNR001093};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285, ECO:0000256|PIRNR:PIRNR001093}.
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DR EMBL; KC855749; AGR44467.1; -; mRNA.
DR AlphaFoldDB; S5M5M0; -.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd06562; GH20_HexA_HexB-like; 1.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR029019; HEX_eukaryotic_N.
DR PANTHER; PTHR22600; BETA-HEXOSAMINIDASE; 1.
DR PANTHER; PTHR22600:SF26; BETA-HEXOSAMINIDASE 2; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR Pfam; PF14845; Glycohydro_20b2; 1.
DR PIRSF; PIRSF001093; B-hxosamndse_ab_euk; 1.
DR PRINTS; PR00738; GLHYDRLASE20.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
PE 2: Evidence at transcript level;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|PIRNR:PIRNR001093};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR001093};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..580
FT /note="Beta-hexosaminidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004537789"
FT DOMAIN 31..151
FT /note="Beta-hexosaminidase eukaryotic type N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14845"
FT DOMAIN 171..527
FT /note="Glycoside hydrolase family 20 catalytic"
FT /evidence="ECO:0000259|Pfam:PF00728"
FT ACT_SITE 337
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001093-1"
SQ SEQUENCE 580 AA; 64131 MW; E073B1F86D9FEAC7 CRC64;
MQILIVILLM GLLLASAAPF SSSQSDSGVN VWPKPRNFSW PQPQAHLLSP NFAITSPANH
KYLSSAVKRY HQLLLSEHHR PLVNPSSSVR INTSAPPLLT LSLTVADLAA PLHHGVDESY
TLTIPITGGA ANLWAQTAWG AMRGLETLSQ LVWGDPSLVA VGVYVWDSPL FGHRGVMLDT
SRNFYGVEDI LRTIEAMSAN KLNVFHWHIT DSHSFPLLLP SEPELASKGS YGSAMQYSPA
DVTKIVEFGL EHAVRVVPEI DAPGHTGSWA EAYPEIVTCA NMFWWPDGVD WADRLASEPG
TGHLNPLNPK TYQVLKNVIH DVSTLFPEPF FHAGADEIIP GCWKADPTIQ SFLSKGGTLS
ELLDLFVNST FPYIVSLNRT VVYWEDVLLD DNVKVQATIL PPEHTILQTW NNGHNNTKRI
VSSGYRVIVS SSEFYYLDCG HGDFLGNDSL YDQQTGSDTG NGGSWCGPFK TWQTIYNYDI
TYGLTEDEAK LVLGGEVALW SEQADPTVLD ARIWPRTSAL AESLWSGNRD AMGMKRYAEA
TDRLNEWRSR IVARGVRAEP IQPLWCIRNP GMCNTVNSFG
//
