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Database: UniProt
Entry: S5MII1_9MOLU
LinkDB: S5MII1_9MOLU
Original site: S5MII1_9MOLU 
ID   S5MII1_9MOLU            Unreviewed;       445 AA.
AC   S5MII1;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   05-JUL-2017, entry version 32.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:AGR41705.1};
GN   ORFNames=SDIMI_v3c00010 {ECO:0000313|EMBL:AGR41705.1};
OS   Spiroplasma diminutum CUAS-1.
OC   Bacteria; Tenericutes; Mollicutes; Entomoplasmatales;
OC   Spiroplasmataceae; Spiroplasma.
OX   NCBI_TaxID=1276221 {ECO:0000313|EMBL:AGR41705.1, ECO:0000313|Proteomes:UP000014983};
RN   [1] {ECO:0000313|EMBL:AGR41705.1, ECO:0000313|Proteomes:UP000014983}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CUAS-1 {ECO:0000313|EMBL:AGR41705.1};
RX   PubMed=23873917; DOI=10.1093/gbe/evt108;
RA   Lo W.S., Ku C., Chen L.L., Chang T.H., Kuo C.H.;
RT   "Comparison of metabolic capacities and inference of gene content
RT   evolution in mosquito-associated Spiroplasma diminutum and S.
RT   taiwanense.";
RL   Genome Biol. Evol. 5:1512-1523(2013).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP005076; AGR41705.1; -; Genomic_DNA.
DR   RefSeq; WP_020835938.1; NC_021833.1.
DR   EnsemblBacteria; AGR41705; AGR41705; SDIMI_v3c00010.
DR   KEGG; sdi:SDIMI_v3c00010; -.
DR   PATRIC; fig|1276221.3.peg.1; -.
DR   KO; K02313; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000014983; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000014983};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014983}.
FT   DOMAIN      136    274       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      353    422       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     144    151       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   445 AA;  50943 MW;  9D31ADA884D2EF4E CRC64;
     MTNTALWKEI KKWLISSDII EPNIYEDYIK NDASIEDLTD NQKAIVVNKD LSKYYLENIS
     HEIKEKISTI LKLDMSISFF TKDEFKKEKK ITEIIIKKNK KNNNSKEFIF NSFILGKSNS
     EAYNASKAVI NNLGNKWNPL FIYGESGLGK THLLKAINNE LNLIDEELNV KYYASNDFRK
     EILDALLGGF KEIEQTKDEM NAIDVLLIDD IQFLANSGKT NEIFFNIFNS FIEEGKQIVI
     TSDKFPEHLN GFDKRLVSRF NQGLSVKIET PDFDTAIKII DYKTEISNLK LDIDSKRFIA
     SHFGTDVRKI EGIINKIEFK LIQEKDSIGE IIELETIQKL LEDYSFAPGG EITVQKIKNV
     VAQNYGINVK SIDAKNKVSN VVLARHVSMY LTNELMKKNY SEIGILFGGK DHTTVINACN
     KVKKSLAEDK IFKNVLKKIK KEIVS
//
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