ID S5PKY6_PANTR Unreviewed; 797 AA.
AC S5PKY6;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Toll-like receptor 10 {ECO:0000313|EMBL:AGR83797.1};
GN Name=TLR10 {ECO:0000313|EMBL:AGR83797.1};
OS Pan troglodytes verus.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=37012 {ECO:0000313|EMBL:AGR83797.1};
RN [1] {ECO:0000313|EMBL:AGR83797.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A04 {ECO:0000313|EMBL:AGR83781.1}, A05
RC {ECO:0000313|EMBL:AGR83783.1}, D04 {ECO:0000313|EMBL:AGR83793.1}, E03
RC {ECO:0000313|EMBL:AGR83797.1}, F04 {ECO:0000313|EMBL:AGR83803.1}, H03
RC {ECO:0000313|EMBL:AGR83809.1}, and H04 {ECO:0000313|EMBL:AGR83811.1};
RX PubMed=23851028; DOI=10.1093/hmg/ddt335;
RA Quach H., Wilson D., Laval G., Patin E., Manry J., Guibert J.,
RA Barreiro L.B., Nerrienet E., Verschoor E., Gessain A., Przeworski M.,
RA Quintana-Murci L.;
RT "Different selective pressures shape the evolution of Toll-like receptors
RT in human and African great ape populations.";
RL Hum. Mol. Genet. 22:4829-4840(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634, ECO:0000256|PIRNR:PIRNR037595}.
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DR EMBL; KF321611; AGR83781.1; -; Genomic_DNA.
DR EMBL; KF321613; AGR83783.1; -; Genomic_DNA.
DR EMBL; KF321623; AGR83793.1; -; Genomic_DNA.
DR EMBL; KF321627; AGR83797.1; -; Genomic_DNA.
DR EMBL; KF321633; AGR83803.1; -; Genomic_DNA.
DR EMBL; KF321639; AGR83809.1; -; Genomic_DNA.
DR EMBL; KF321641; AGR83811.1; -; Genomic_DNA.
DR AlphaFoldDB; S5PKY6; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-UniRule.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-UniRule.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF23; TOLL-LIKE RECEPTOR 10; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF01582; TIR; 1.
DR PIRSF; PIRSF037595; Toll-like_receptor; 1.
DR SMART; SM00369; LRR_TYP; 4.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|PIRNR:PIRNR037595};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR037595};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 563..585
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 618..761
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 797 AA; 92833 MW; 58A499D1E01A28D3 CRC64;
MTVEGDAPEL PEERELMTNC SNMSLRKVPA DLTPATTTLD LSYNLLFQLQ SSDFHSVSKL
RVLILCHNRI QQLDLKTFEF NKELRYLDLS NNRLKSVTWY LLAGLRYLDL SFNDFDTMPI
CEEAGNMSHL EILGLSGAKI QKSDFQKIAH LHLNTVFLGF RTLSHYEEGS LPILNTTKLH
IVLPMDTNFW VLLRDGIKTS KILEMTNIDG KSQFVSYEMQ RNLSLENAKT SILLLNKVDL
LWDDLFLILQ FVWHTSVEHF QIQNVTFGGK AYLDHNSFDY SNTVMRTIKL EHVHFRVFYI
QQDKIYLLLT KMDIENLTIS NAQMPHMLFP NYPTKFQYLN FANNILTDEL FKRTIQLPHL
KTLILNGNKL ETLSLVSCFA NNTPLEHLDL SQNLLQHKND ENCSWPETVV NMNLSYNKLS
DSVFRCLPKS IQILDLNNNK IQTVPKETIH LMALRELNIA FNFLTDLPGC SHFSRLSILN
IEMNFILSPS LDFVQSCQEV KTLNAGRNPF RCTCELKNFI QLETYSEVMM VGWSDSYTCE
YPLNLRGTRL KDVHLHELSC NTALLIVTIV VIMLVLGLAV AFCCLHFDLP WYLRMLGQCT
QTWHRVRKTT QEQLKRNVRF HAFISYSEHD SLWVKNELIP NLEKEDGSIL ICLYESYFDP
GKSISENIVS FIEKSYKSIF VLSPNFVQNE WCHYEFYFAH HNLFHENSDH IILILLEPIP
FYCIPTRYHK LKALLEKKAY LEWPKDRRKC GLFWANLRAA INVNVSATRE MYELQTFTEL
NEESRGSTIS LMRTDCL
//
