ID S5PN45_PANTR Unreviewed; 752 AA.
AC S5PN45;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Toll-like receptor 4 {ECO:0000256|ARBA:ARBA00040109};
DE Flags: Fragment;
GN Name=TLR4 {ECO:0000313|EMBL:AGR83234.1};
OS Pan troglodytes verus.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=37012 {ECO:0000313|EMBL:AGR83234.1};
RN [1] {ECO:0000313|EMBL:AGR83234.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=E04 {ECO:0000313|EMBL:AGR83234.1};
RX PubMed=23851028; DOI=10.1093/hmg/ddt335;
RA Quach H., Wilson D., Laval G., Patin E., Manry J., Guibert J.,
RA Barreiro L.B., Nerrienet E., Verschoor E., Gessain A., Przeworski M.,
RA Quintana-Murci L.;
RT "Different selective pressures shape the evolution of Toll-like receptors
RT in human and African great ape populations.";
RL Hum. Mol. Genet. 22:4829-4840(2013).
CC -!- SUBCELLULAR LOCATION: Cell projection, ruffle
CC {ECO:0000256|ARBA:ARBA00004466}. Early endosome
CC {ECO:0000256|ARBA:ARBA00004412}. Endosome
CC {ECO:0000256|ARBA:ARBA00004177}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; KF320634; AGR83234.1; -; Genomic_DNA.
DR EMBL; KF320635; AGR83235.1; -; Genomic_DNA.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF521; TOLL-LIKE RECEPTOR 4; 1.
DR Pfam; PF12799; LRR_4; 1.
DR Pfam; PF13516; LRR_6; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF01582; TIR; 1.
DR PIRSF; PIRSF037595; Toll-like_receptor; 4.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00365; LRR_SD22; 5.
DR SMART; SM00369; LRR_TYP; 9.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:AGR83234.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 546..565
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 585..728
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AGR83234.1"
SQ SEQUENCE 752 AA; 85718 MW; DEC63963C17DCBB1 CRC64;
CEIQTIEDGA YQSLSHLSTL ILTGNPIQSL ALGAFSGLSS LQKLVAVETN LASLENFPIG
HLKTLKELNV AHNLIQSFKL PEYFSNLTNL EHLDLSSNKI QSIYCTDLRV LHQMPLLNLS
LDLSLNPMNF IQPGAFKEIR LHKLTLRNNF DSLNVMKTCI QGLAGLEVHR LVLGEFRNEG
NLEKFDKSAL EGLCNLTIEE FRLAYLDYYL DDIIDLFNCL TNVSSFSLVS VTIKSVKDFS
YNFGWQHLEL VNCKFGQFPT LKLKSLKRLT FTSNKGGNAF SEVDLPSLEF LDLSRNGLSF
KGCCSQSDFG TTSLKYLDLS FNGVITMSSN FLGLEQLEHL DFQHSNLKQM SEFSVFLSLR
NLIYLDISHT HTRVAFNGIF NGLSSLEVLK MAGNSFQENF LPDIFTELRN LTFLDLSQCQ
LEQLSPTAFN SLSSLQVLNM SHNNFFSLDT FPYKCLNSLQ VLDYSLNHIM TSKKQELQHF
PSSLAFLNLT QNDFACTCEH QSFLQWIKDQ RQLLVEVERM ECATPSDKQG MPVLSLNITC
QMNKTIIGVS VLSVLVVSVV AVLVYKFYFH LMLLAGCIKY GRGENIYDAF VIYSSQDEDW
VRNELVKNLE EGVPPFQLCL HYRDFIPGVA IAANIIHEGF HKSRKVIVVV SQHFIQSRWC
IFEYEIAQTW QFLSSRAGII FIVLQKVEKT LLRRQVELYR LLSRNTYLEW EDSVLGRHIF
WRRLRKALLD GKSWNPEGTV GTGCNWQEAT SX
//
